pk 11195 has been researched along with Epilepsy in 8 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Brackhan, M | 1 |
| Bascuñana, P | 1 |
| Postema, JM | 1 |
| Ross, TL | 1 |
| Bengel, FM | 1 |
| Bankstahl, M | 1 |
| Bankstahl, JP | 1 |
| Butler, T | 1 |
| Ichise, M | 1 |
| Teich, AF | 1 |
| Gerard, E | 1 |
| Osborne, J | 1 |
| French, J | 1 |
| Devinsky, O | 1 |
| Kuzniecky, R | 1 |
| Gilliam, F | 1 |
| Pervez, F | 1 |
| Provenzano, F | 1 |
| Goldsmith, S | 1 |
| Vallabhajosula, S | 1 |
| Stern, E | 1 |
| Silbersweig, D | 1 |
| Kumar, A | 1 |
| Chugani, HT | 1 |
| Luat, A | 1 |
| Asano, E | 1 |
| Sood, S | 1 |
| Larkin, JG | 1 |
| McKee, PJ | 1 |
| Thompson, GG | 1 |
| Brodie, MJ | 1 |
| Nakamoto, Y | 1 |
| Watabe, S | 1 |
| Shiotani, T | 1 |
| Yoshii, M | 1 |
| Caldiroli, E | 1 |
| De Ponti, F | 1 |
| Cosentino, M | 1 |
| Marino, F | 1 |
| Fietta, AM | 1 |
| Taddei, M | 1 |
| Tartara, A | 1 |
| Zibetti, A | 1 |
| Mazzone, A | 1 |
| Lecchini, S | 1 |
| Frigo, GM | 1 |
| Weizman, A | 1 |
| Tanne, Z | 1 |
| Karp, L | 1 |
| Martfeld, Y | 1 |
| Tyano, S | 1 |
| Gavish, M | 1 |
8 other studies available for pk 11195 and Epilepsy
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Serial Quantitative TSPO-Targeted PET Reveals Peak Microglial Activation up to 2 Weeks After an Epileptogenic Brain Insult.
Topics: Animals; Brain; Epilepsy; Female; Isoquinolines; Microglia; Pathology, Molecular; Positron-Emission | 2016 |
Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia.
Topics: Adult; Diagnosis, Differential; Encephalitis; Epilepsy; Female; Humans; Isoquinolines; Malformations | 2013 |
Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography.
Topics: Antineoplastic Agents; Brain; Child, Preschool; Drug Resistance; Encephalitis; Epilepsy; Hemianopsia | 2008 |
Peripheral benzodiazepine receptors in platelets of epileptic patients.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; B | 1993 |
Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding Sites; Cell Fractionation; Convulsants; Epi | 1996 |
Carbamazepine affects neutrophil function through an action on peripheral benzodiazepine receptors.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Carbamazepine; Cells, Cultured; Chemotaxis, Leukocyte; C | 1997 |
Carbamazepine up-regulates the binding of [3H]PK 11195 to platelets of epileptic patients.
Topics: Adolescent; Adult; Blood Platelets; Carbamazepine; Cell Membrane; Epilepsy; Female; Humans; Isoquino | 1987 |