Page last updated: 2024-10-21

pk 11195 and Encephalitis

pk 11195 has been researched along with Encephalitis in 30 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Encephalitis: Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.

Research Excerpts

ExcerptRelevanceReference
"With the main objective of comparing the prospective diagnostic power of two 11C-labelled molecular imaging biomarkers with affinity for TSPO and used for the visualisation of activated microglia after a stroke, we measured with positron emission tomography (PET) in four post-stroke patients the regional brain uptake and binding potential of [11C]vinpocetine and [11C]PK11195."7.78Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine. ( Gulyas, B; Halldin, C; Hillert, J; Kostulas, K; Shchukin, E; Toth, M; Vas, A, 2012)
"With the main objective of comparing the prospective diagnostic power of two 11C-labelled molecular imaging biomarkers with affinity for TSPO and used for the visualisation of activated microglia after a stroke, we measured with positron emission tomography (PET) in four post-stroke patients the regional brain uptake and binding potential of [11C]vinpocetine and [11C]PK11195."3.78Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine. ( Gulyas, B; Halldin, C; Hillert, J; Kostulas, K; Shchukin, E; Toth, M; Vas, A, 2012)
"Such focal brain inflammation aggravates secondary brain injury by exacerbating blood-brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death."2.61Global brain inflammation in stroke. ( Ducruet, AF; Lawton, MT; Li, ZG; Shi, FD; Shi, K; Tian, DC, 2019)
"In general, neurodegenerative diseases have unpredictable clinical courses and timely effective treatment is not available."2.43Nuclear imaging of inflammation in neurologic and psychiatric disorders. ( de Vries, EF; Dierckx, RA; Klein, HC, 2006)
"Fibromyalgia (FM) and complex regional pain syndrome (CRPS) share many pathological mechanisms related to chronic pain and neuroinflammation, which may contribute to the multifactorial pathological mechanisms in both FM and CRPS."1.62Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET. ( Cheon, GJ; Choi, SH; Jang, JH; Jung, YH; Kang, DH; Lee, D; Lee, JS; Lee, JY; Lee, WJ; Moon, JY; Seo, S, 2021)
"Twenty-six (62%) of 42 mild cognitive impairment cases showed a raised cortical amyloid load compared to healthy controls."1.46Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease. ( Aanerud, J; Amidi, A; Borghammer, P; Brooks, DJ; Brændgaard, H; Edison, P; Eriksson, BO; Eskildsen, SF; Gottrup, H; Hansen, KV; Hinz, R; Ismail, R; Lund, TE; Mårup, FH; Parbo, P; Pavese, N; Stokholm, MG; Tietze, A, 2017)
"Ferulic acid is a natural compound that expresses antioxidant and anti-inflammatory activities."1.32Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. ( Gasparini, L; Hauss-Wegrzyniak, B; Maucci, R; McGann-Gramling, K; Ongini, E; Ronchetti, D; Rosi, S; Wenk, GL, 2004)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.33)18.2507
2000's17 (56.67)29.6817
2010's11 (36.67)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Seo, S1
Jung, YH1
Lee, D1
Lee, WJ1
Jang, JH1
Lee, JY1
Choi, SH1
Moon, JY1
Lee, JS1
Cheon, GJ1
Kang, DH1
Parbo, P1
Ismail, R1
Hansen, KV1
Amidi, A1
Mårup, FH1
Gottrup, H1
Brændgaard, H1
Eriksson, BO1
Eskildsen, SF1
Lund, TE1
Tietze, A1
Edison, P1
Pavese, N1
Stokholm, MG1
Borghammer, P1
Hinz, R2
Aanerud, J1
Brooks, DJ2
Shi, K1
Tian, DC1
Li, ZG1
Ducruet, AF1
Lawton, MT1
Shi, FD1
Haarman, BC1
Riemersma-Van der Lek, RF1
de Groot, JC1
Ruhé, HG1
Klein, HC2
Zandstra, TE1
Burger, H1
Schoevers, RA1
de Vries, EF2
Drexhage, HA1
Nolen, WA1
Doorduin, J1
Hunter, HJ1
Gerhard, A1
Talbot, PS1
Su, Z1
Holland, G1
Hopkins, SJ1
Griffiths, CE1
Kleyn, CE1
Ma, L1
Zhang, H1
Liu, N1
Wang, PQ1
Guo, WZ1
Fu, Q1
Jiao, LB1
Ma, YQ1
Mi, WD1
Dierckx, RA2
Wiley, CA3
Lopresti, BJ2
Venneti, S3
Price, J1
Klunk, WE1
DeKosky, ST1
Mathis, CA2
Kannan, S1
Balakrishnan, B1
Muzik, O1
Romero, R1
Chugani, D1
Hirshler, YK1
Polat, U1
Biegon, A2
Ouchi, Y1
Yagi, S1
Yokokura, M1
Sakamoto, M1
Drouin-Ouellet, J1
Brownell, AL2
Saint-Pierre, M1
Fasano, C1
Emond, V1
Trudeau, LE1
Lévesque, D1
Cicchetti, F2
Butler, T1
Ichise, M1
Teich, AF1
Gerard, E1
Osborne, J1
French, J1
Devinsky, O1
Kuzniecky, R1
Gilliam, F1
Pervez, F1
Provenzano, F1
Goldsmith, S1
Vallabhajosula, S1
Stern, E1
Silbersweig, D1
Gulyas, B1
Toth, M1
Vas, A1
Shchukin, E1
Kostulas, K1
Hillert, J1
Halldin, C1
Rueger, MA1
Muesken, S1
Walberer, M1
Jantzen, SU1
Schnakenburg, K1
Backes, H1
Graf, R1
Neumaier, B1
Hoehn, M1
Fink, GR1
Schroeter, M1
Cao, T1
Thomas, TC1
Ziebell, JM1
Pauly, JR1
Lifshitz, J1
Alvarado, M1
Budinger, TF1
Grossman, R1
Hensley, K1
West, MS1
Kotake, Y1
Ono, M1
Floyd, RA1
Banati, RB2
Versijpt, JJ1
Dumont, F1
Van Laere, KJ1
Decoo, D1
Santens, P1
Audenaert, K1
Achten, E1
Slegers, G1
Korf, J1
Wilms, H1
Claasen, J1
Röhl, C1
Sievers, J1
Deuschl, G1
Lucius, R1
Wenk, GL1
McGann-Gramling, K1
Hauss-Wegrzyniak, B1
Ronchetti, D1
Maucci, R1
Rosi, S1
Gasparini, L1
Ongini, E1
Ryu, JK1
Choi, HB1
McLarnon, JG1
Wang, G2
Slagel, SL1
Mason, NS1
Fischer, ML1
Larsen, NJ1
Mortimer, AD1
Hastings, TG1
Smith, AD1
Zigmond, MJ1
Suhara, T1
Higuchi, M1
Veiga, S1
Carrero, P1
Pernia, O1
Azcoitia, I1
Garcia-Segura, LM1
Boutin, H1
Chauveau, F1
Thominiaux, C1
Kuhnast, B1
Grégoire, MC1
Jan, S1
Trebossen, R1
Dollé, F1
Tavitian, B1
Mattner, F1
Katsifis, A1
Yanamoto, K1
Zhang, MR1
Kumata, K1
Hatori, A1
Okada, M1
Suzuki, K1
Kumar, A1
Chugani, HT1
Luat, A1
Asano, E1
Sood, S1
Goerres, GW1
Myers, R1
Gunn, RN1
Turkheimer, FE1
Kreutzberg, GW1
Jones, T1
Duncan, JS1
Williams, K1
Chen, YI1
Livni, E1
Isacson, O1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke: A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Phase III Trial[NCT05836740]Phase 31,672 participants (Anticipated)Interventional2023-05-19Recruiting
Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy: A Phase II, Randomized, Multicenter, Double-blind, Single Dose, Placebo-controlled Parallel Trial[NCT05836753]Phase 2120 participants (Anticipated)Interventional2023-05-07Recruiting
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis[NCT00547976]Phase 15 participants (Actual)Interventional2007-10-31Completed
Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis[NCT00563537]Phase 130 participants (Anticipated)Interventional2007-01-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for pk 11195 and Encephalitis

ArticleYear
Global brain inflammation in stroke.
    The Lancet. Neurology, 2019, Volume: 18, Issue:11

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma

2019
Global brain inflammation in stroke.
    The Lancet. Neurology, 2019, Volume: 18, Issue:11

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma

2019
Global brain inflammation in stroke.
    The Lancet. Neurology, 2019, Volume: 18, Issue:11

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma

2019
Global brain inflammation in stroke.
    The Lancet. Neurology, 2019, Volume: 18, Issue:11

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma

2019
Nuclear imaging of inflammation in neurologic and psychiatric disorders.
    Current clinical pharmacology, 2006, Volume: 1, Issue:3

    Topics: Anti-Bacterial Agents; Antiviral Agents; Carbon Radioisotopes; Cyclooxygenase 2; Encephalitis; Human

2006
Positron emission tomography imaging of neuroinflammation.
    Journal of child neurology, 2009, Volume: 24, Issue:9

    Topics: Animals; Antineoplastic Agents; Brain Mapping; Carbon Isotopes; Disease Models, Animal; Encephalitis

2009
Neuroinflammation in the living brain of Parkinson's disease.
    Parkinsonism & related disorders, 2009, Volume: 15 Suppl 3

    Topics: Aged; Brain; Cocaine; Cytokines; Dopamine Plasma Membrane Transport Proteins; Encephalitis; Humans;

2009
Visualising microglial activation in vivo.
    Glia, 2002, Volume: 40, Issue:2

    Topics: Animals; Binding Sites; Brain Diseases; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; L

2002
Visualising microglial activation in vivo.
    Glia, 2002, Volume: 40, Issue:2

    Topics: Animals; Binding Sites; Brain Diseases; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; L

2002
Visualising microglial activation in vivo.
    Glia, 2002, Volume: 40, Issue:2

    Topics: Animals; Binding Sites; Brain Diseases; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; L

2002
Visualising microglial activation in vivo.
    Glia, 2002, Volume: 40, Issue:2

    Topics: Animals; Binding Sites; Brain Diseases; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; L

2002

Other Studies

25 other studies available for pk 11195 and Encephalitis

ArticleYear
Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET.
    PloS one, 2021, Volume: 16, Issue:2

    Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Complex Regional Pain Syndromes; Encephali

2021
Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease.
    Brain : a journal of neurology, 2017, Jul-01, Volume: 140, Issue:7

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Case-Control Studies; Cerebr

2017
Neuroinflammation in bipolar disorder - A [(11)C]-(R)-PK11195 positron emission tomography study.
    Brain, behavior, and immunity, 2014, Volume: 40

    Topics: Adult; Aged; Bipolar Disorder; Carbon Radioisotopes; Encephalitis; Female; Hippocampus; Humans; Isoq

2014
Brain inflammation and psoriasis: a [
    The British journal of dermatology, 2016, Volume: 175, Issue:5

    Topics: Adolescent; Adult; Carbon Radioisotopes; Chronic Disease; Encephalitis; Female; Humans; Isoquinoline

2016
TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration.
    Brain research bulletin, 2016, Volume: 121

    Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Aspa

2016
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
    Archives of neurology, 2009, Volume: 66, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antineoplastic

2009
Intracranial electrode implantation produces regional neuroinflammation and memory deficits in rats.
    Experimental neurology, 2010, Volume: 222, Issue:1

    Topics: Analysis of Variance; Animals; Autoradiography; Brain; Deep Brain Stimulation; Disease Models, Anima

2010
Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.
    Glia, 2011, Volume: 59, Issue:2

    Topics: Amphetamine; Animals; Animals, Newborn; Anti-Inflammatory Agents; Behavior, Animal; Cells, Cultured;

2011
Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2013, Volume: 23, Issue:1

    Topics: Adult; Diagnosis, Differential; Encephalitis; Epilepsy; Female; Humans; Isoquinolines; Malformations

2013
Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine.
    Current radiopharmaceuticals, 2012, Volume: 5, Issue:1

    Topics: Aged; Binding Sites; Biomarkers; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; Male; Mi

2012
Effects of minocycline on endogenous neural stem cells after experimental stroke.
    Neuroscience, 2012, Jul-26, Volume: 215

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Anti-Bacterial Agents; Brain Infarction; Brain

2012
Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat.
    Neuroscience, 2012, Dec-06, Volume: 225

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Calcium-Bind

2012
Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain.
    Journal of neurochemistry, 2002, Volume: 82, Issue:4

    Topics: Animals; Antioxidants; Autoradiography; Binding, Competitive; Brain; Cyclic N-Oxides; Disease Models

2002
Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. A pilot study.
    European neurology, 2003, Volume: 50, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain Mapping; Dominance, Cerebral; Encephalitis; Female

2003
Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro.
    Neurobiology of disease, 2003, Volume: 14, Issue:3

    Topics: Animals; Animals, Newborn; Benzodiazepines; Binding Sites; Cell Division; Cells, Cultured; Encephali

2003
Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid.
    Journal of neurochemistry, 2004, Volume: 89, Issue:2

    Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Chronic Disease; Coumar

2004
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
    Neurobiology of disease, 2005, Volume: 20, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases;

2005
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.
    Journal of neurochemistry, 2007, Volume: 102, Issue:6

    Topics: Acetamides; Animals; Binding, Competitive; Brain; Disease Models, Animal; Encephalitis; Gliosis; Iso

2007
Translocator protein 18 kDa is involved in the regulation of reactive gliosis.
    Glia, 2007, Nov-01, Volume: 55, Issue:14

    Topics: Animals; Antineoplastic Agents; Astrocytes; Benzodiazepinones; Biomarkers; Cell Death; Cell Prolifer

2007
In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.
    Glia, 2007, Nov-01, Volume: 55, Issue:14

    Topics: Acetamides; Animals; Antineoplastic Agents; Binding, Competitive; Brain; Carbon Radioisotopes; Disea

2007
Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.
    Neuroscience letters, 2007, Oct-16, Volume: 426, Issue:2

    Topics: Analysis of Variance; Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Butadie

2007
In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats.
    Neuroscience letters, 2007, Nov-27, Volume: 428, Issue:2-3

    Topics: Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Brain; Carbon Radioisotopes;

2007
Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography.
    Pediatric neurology, 2008, Volume: 38, Issue:6

    Topics: Antineoplastic Agents; Brain; Child, Preschool; Drug Resistance; Encephalitis; Epilepsy; Hemianopsia

2008
[11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis.
    Neurology, 1999, Dec-10, Volume: 53, Issue:9

    Topics: Adolescent; Adult; Biomarkers; Brain; Brain Mapping; Diagnosis, Differential; Encephalitis; Epilepsi

1999
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
    The European journal of neuroscience, 2002, Volume: 15, Issue:6

    Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins;

2002