pk 11195 has been researched along with Encephalitis in 30 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Encephalitis: Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "With the main objective of comparing the prospective diagnostic power of two 11C-labelled molecular imaging biomarkers with affinity for TSPO and used for the visualisation of activated microglia after a stroke, we measured with positron emission tomography (PET) in four post-stroke patients the regional brain uptake and binding potential of [11C]vinpocetine and [11C]PK11195." | 7.78 | Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine. ( Gulyas, B; Halldin, C; Hillert, J; Kostulas, K; Shchukin, E; Toth, M; Vas, A, 2012) |
| "With the main objective of comparing the prospective diagnostic power of two 11C-labelled molecular imaging biomarkers with affinity for TSPO and used for the visualisation of activated microglia after a stroke, we measured with positron emission tomography (PET) in four post-stroke patients the regional brain uptake and binding potential of [11C]vinpocetine and [11C]PK11195." | 3.78 | Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine. ( Gulyas, B; Halldin, C; Hillert, J; Kostulas, K; Shchukin, E; Toth, M; Vas, A, 2012) |
| "Such focal brain inflammation aggravates secondary brain injury by exacerbating blood-brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death." | 2.61 | Global brain inflammation in stroke. ( Ducruet, AF; Lawton, MT; Li, ZG; Shi, FD; Shi, K; Tian, DC, 2019) |
| "In general, neurodegenerative diseases have unpredictable clinical courses and timely effective treatment is not available." | 2.43 | Nuclear imaging of inflammation in neurologic and psychiatric disorders. ( de Vries, EF; Dierckx, RA; Klein, HC, 2006) |
| "Fibromyalgia (FM) and complex regional pain syndrome (CRPS) share many pathological mechanisms related to chronic pain and neuroinflammation, which may contribute to the multifactorial pathological mechanisms in both FM and CRPS." | 1.62 | Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET. ( Cheon, GJ; Choi, SH; Jang, JH; Jung, YH; Kang, DH; Lee, D; Lee, JS; Lee, JY; Lee, WJ; Moon, JY; Seo, S, 2021) |
| "Twenty-six (62%) of 42 mild cognitive impairment cases showed a raised cortical amyloid load compared to healthy controls." | 1.46 | Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease. ( Aanerud, J; Amidi, A; Borghammer, P; Brooks, DJ; Brændgaard, H; Edison, P; Eriksson, BO; Eskildsen, SF; Gottrup, H; Hansen, KV; Hinz, R; Ismail, R; Lund, TE; Mårup, FH; Parbo, P; Pavese, N; Stokholm, MG; Tietze, A, 2017) |
| "Ferulic acid is a natural compound that expresses antioxidant and anti-inflammatory activities." | 1.32 | Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. ( Gasparini, L; Hauss-Wegrzyniak, B; Maucci, R; McGann-Gramling, K; Ongini, E; Ronchetti, D; Rosi, S; Wenk, GL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 17 (56.67) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Seo, S | 1 |
| Jung, YH | 1 |
| Lee, D | 1 |
| Lee, WJ | 1 |
| Jang, JH | 1 |
| Lee, JY | 1 |
| Choi, SH | 1 |
| Moon, JY | 1 |
| Lee, JS | 1 |
| Cheon, GJ | 1 |
| Kang, DH | 1 |
| Parbo, P | 1 |
| Ismail, R | 1 |
| Hansen, KV | 1 |
| Amidi, A | 1 |
| Mårup, FH | 1 |
| Gottrup, H | 1 |
| Brændgaard, H | 1 |
| Eriksson, BO | 1 |
| Eskildsen, SF | 1 |
| Lund, TE | 1 |
| Tietze, A | 1 |
| Edison, P | 1 |
| Pavese, N | 1 |
| Stokholm, MG | 1 |
| Borghammer, P | 1 |
| Hinz, R | 2 |
| Aanerud, J | 1 |
| Brooks, DJ | 2 |
| Shi, K | 1 |
| Tian, DC | 1 |
| Li, ZG | 1 |
| Ducruet, AF | 1 |
| Lawton, MT | 1 |
| Shi, FD | 1 |
| Haarman, BC | 1 |
| Riemersma-Van der Lek, RF | 1 |
| de Groot, JC | 1 |
| Ruhé, HG | 1 |
| Klein, HC | 2 |
| Zandstra, TE | 1 |
| Burger, H | 1 |
| Schoevers, RA | 1 |
| de Vries, EF | 2 |
| Drexhage, HA | 1 |
| Nolen, WA | 1 |
| Doorduin, J | 1 |
| Hunter, HJ | 1 |
| Gerhard, A | 1 |
| Talbot, PS | 1 |
| Su, Z | 1 |
| Holland, G | 1 |
| Hopkins, SJ | 1 |
| Griffiths, CE | 1 |
| Kleyn, CE | 1 |
| Ma, L | 1 |
| Zhang, H | 1 |
| Liu, N | 1 |
| Wang, PQ | 1 |
| Guo, WZ | 1 |
| Fu, Q | 1 |
| Jiao, LB | 1 |
| Ma, YQ | 1 |
| Mi, WD | 1 |
| Dierckx, RA | 2 |
| Wiley, CA | 3 |
| Lopresti, BJ | 2 |
| Venneti, S | 3 |
| Price, J | 1 |
| Klunk, WE | 1 |
| DeKosky, ST | 1 |
| Mathis, CA | 2 |
| Kannan, S | 1 |
| Balakrishnan, B | 1 |
| Muzik, O | 1 |
| Romero, R | 1 |
| Chugani, D | 1 |
| Hirshler, YK | 1 |
| Polat, U | 1 |
| Biegon, A | 2 |
| Ouchi, Y | 1 |
| Yagi, S | 1 |
| Yokokura, M | 1 |
| Sakamoto, M | 1 |
| Drouin-Ouellet, J | 1 |
| Brownell, AL | 2 |
| Saint-Pierre, M | 1 |
| Fasano, C | 1 |
| Emond, V | 1 |
| Trudeau, LE | 1 |
| Lévesque, D | 1 |
| Cicchetti, F | 2 |
| Butler, T | 1 |
| Ichise, M | 1 |
| Teich, AF | 1 |
| Gerard, E | 1 |
| Osborne, J | 1 |
| French, J | 1 |
| Devinsky, O | 1 |
| Kuzniecky, R | 1 |
| Gilliam, F | 1 |
| Pervez, F | 1 |
| Provenzano, F | 1 |
| Goldsmith, S | 1 |
| Vallabhajosula, S | 1 |
| Stern, E | 1 |
| Silbersweig, D | 1 |
| Gulyas, B | 1 |
| Toth, M | 1 |
| Vas, A | 1 |
| Shchukin, E | 1 |
| Kostulas, K | 1 |
| Hillert, J | 1 |
| Halldin, C | 1 |
| Rueger, MA | 1 |
| Muesken, S | 1 |
| Walberer, M | 1 |
| Jantzen, SU | 1 |
| Schnakenburg, K | 1 |
| Backes, H | 1 |
| Graf, R | 1 |
| Neumaier, B | 1 |
| Hoehn, M | 1 |
| Fink, GR | 1 |
| Schroeter, M | 1 |
| Cao, T | 1 |
| Thomas, TC | 1 |
| Ziebell, JM | 1 |
| Pauly, JR | 1 |
| Lifshitz, J | 1 |
| Alvarado, M | 1 |
| Budinger, TF | 1 |
| Grossman, R | 1 |
| Hensley, K | 1 |
| West, MS | 1 |
| Kotake, Y | 1 |
| Ono, M | 1 |
| Floyd, RA | 1 |
| Banati, RB | 2 |
| Versijpt, JJ | 1 |
| Dumont, F | 1 |
| Van Laere, KJ | 1 |
| Decoo, D | 1 |
| Santens, P | 1 |
| Audenaert, K | 1 |
| Achten, E | 1 |
| Slegers, G | 1 |
| Korf, J | 1 |
| Wilms, H | 1 |
| Claasen, J | 1 |
| Röhl, C | 1 |
| Sievers, J | 1 |
| Deuschl, G | 1 |
| Lucius, R | 1 |
| Wenk, GL | 1 |
| McGann-Gramling, K | 1 |
| Hauss-Wegrzyniak, B | 1 |
| Ronchetti, D | 1 |
| Maucci, R | 1 |
| Rosi, S | 1 |
| Gasparini, L | 1 |
| Ongini, E | 1 |
| Ryu, JK | 1 |
| Choi, HB | 1 |
| McLarnon, JG | 1 |
| Wang, G | 2 |
| Slagel, SL | 1 |
| Mason, NS | 1 |
| Fischer, ML | 1 |
| Larsen, NJ | 1 |
| Mortimer, AD | 1 |
| Hastings, TG | 1 |
| Smith, AD | 1 |
| Zigmond, MJ | 1 |
| Suhara, T | 1 |
| Higuchi, M | 1 |
| Veiga, S | 1 |
| Carrero, P | 1 |
| Pernia, O | 1 |
| Azcoitia, I | 1 |
| Garcia-Segura, LM | 1 |
| Boutin, H | 1 |
| Chauveau, F | 1 |
| Thominiaux, C | 1 |
| Kuhnast, B | 1 |
| Grégoire, MC | 1 |
| Jan, S | 1 |
| Trebossen, R | 1 |
| Dollé, F | 1 |
| Tavitian, B | 1 |
| Mattner, F | 1 |
| Katsifis, A | 1 |
| Yanamoto, K | 1 |
| Zhang, MR | 1 |
| Kumata, K | 1 |
| Hatori, A | 1 |
| Okada, M | 1 |
| Suzuki, K | 1 |
| Kumar, A | 1 |
| Chugani, HT | 1 |
| Luat, A | 1 |
| Asano, E | 1 |
| Sood, S | 1 |
| Goerres, GW | 1 |
| Myers, R | 1 |
| Gunn, RN | 1 |
| Turkheimer, FE | 1 |
| Kreutzberg, GW | 1 |
| Jones, T | 1 |
| Duncan, JS | 1 |
| Williams, K | 1 |
| Chen, YI | 1 |
| Livni, E | 1 |
| Isacson, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke: A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Phase III Trial[NCT05836740] | Phase 3 | 1,672 participants (Anticipated) | Interventional | 2023-05-19 | Recruiting | ||
| Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy: A Phase II, Randomized, Multicenter, Double-blind, Single Dose, Placebo-controlled Parallel Trial[NCT05836753] | Phase 2 | 120 participants (Anticipated) | Interventional | 2023-05-07 | Recruiting | ||
| PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis[NCT00547976] | Phase 1 | 5 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis[NCT00563537] | Phase 1 | 30 participants (Anticipated) | Interventional | 2007-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for pk 11195 and Encephalitis
| Article | Year |
|---|---|
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Nuclear imaging of inflammation in neurologic and psychiatric disorders.
Topics: Anti-Bacterial Agents; Antiviral Agents; Carbon Radioisotopes; Cyclooxygenase 2; Encephalitis; Human | 2006 |
Positron emission tomography imaging of neuroinflammation.
Topics: Animals; Antineoplastic Agents; Brain Mapping; Carbon Isotopes; Disease Models, Animal; Encephalitis | 2009 |
Neuroinflammation in the living brain of Parkinson's disease.
Topics: Aged; Brain; Cocaine; Cytokines; Dopamine Plasma Membrane Transport Proteins; Encephalitis; Humans; | 2009 |
Visualising microglial activation in vivo.
Topics: Animals; Binding Sites; Brain Diseases; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; L | 2002 |
Visualising microglial activation in vivo.
Topics: Animals; Binding Sites; Brain Diseases; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; L | 2002 |
Visualising microglial activation in vivo.
Topics: Animals; Binding Sites; Brain Diseases; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; L | 2002 |
Visualising microglial activation in vivo.
Topics: Animals; Binding Sites; Brain Diseases; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; L | 2002 |
25 other studies available for pk 11195 and Encephalitis
| Article | Year |
|---|---|
Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET.
Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Complex Regional Pain Syndromes; Encephali | 2021 |
Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Case-Control Studies; Cerebr | 2017 |
Neuroinflammation in bipolar disorder - A [(11)C]-(R)-PK11195 positron emission tomography study.
Topics: Adult; Aged; Bipolar Disorder; Carbon Radioisotopes; Encephalitis; Female; Hippocampus; Humans; Isoq | 2014 |
Brain inflammation and psoriasis: a [
Topics: Adolescent; Adult; Carbon Radioisotopes; Chronic Disease; Encephalitis; Female; Humans; Isoquinoline | 2016 |
TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Aspa | 2016 |
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antineoplastic | 2009 |
Intracranial electrode implantation produces regional neuroinflammation and memory deficits in rats.
Topics: Analysis of Variance; Animals; Autoradiography; Brain; Deep Brain Stimulation; Disease Models, Anima | 2010 |
Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.
Topics: Amphetamine; Animals; Animals, Newborn; Anti-Inflammatory Agents; Behavior, Animal; Cells, Cultured; | 2011 |
Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia.
Topics: Adult; Diagnosis, Differential; Encephalitis; Epilepsy; Female; Humans; Isoquinolines; Malformations | 2013 |
Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine.
Topics: Aged; Binding Sites; Biomarkers; Carbon Radioisotopes; Encephalitis; Humans; Isoquinolines; Male; Mi | 2012 |
Effects of minocycline on endogenous neural stem cells after experimental stroke.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Anti-Bacterial Agents; Brain Infarction; Brain | 2012 |
Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Calcium-Bind | 2012 |
Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain.
Topics: Animals; Antioxidants; Autoradiography; Binding, Competitive; Brain; Cyclic N-Oxides; Disease Models | 2002 |
Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. A pilot study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain Mapping; Dominance, Cerebral; Encephalitis; Female | 2003 |
Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro.
Topics: Animals; Animals, Newborn; Benzodiazepines; Binding Sites; Cell Division; Cells, Cultured; Encephali | 2003 |
Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Chronic Disease; Coumar | 2004 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.
Topics: Acetamides; Animals; Binding, Competitive; Brain; Disease Models, Animal; Encephalitis; Gliosis; Iso | 2007 |
Translocator protein 18 kDa is involved in the regulation of reactive gliosis.
Topics: Animals; Antineoplastic Agents; Astrocytes; Benzodiazepinones; Biomarkers; Cell Death; Cell Prolifer | 2007 |
In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.
Topics: Acetamides; Animals; Antineoplastic Agents; Binding, Competitive; Brain; Carbon Radioisotopes; Disea | 2007 |
Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Butadie | 2007 |
In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats.
Topics: Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Brain; Carbon Radioisotopes; | 2007 |
Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography.
Topics: Antineoplastic Agents; Brain; Child, Preschool; Drug Resistance; Encephalitis; Epilepsy; Hemianopsia | 2008 |
[11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis.
Topics: Adolescent; Adult; Biomarkers; Brain; Brain Mapping; Diagnosis, Differential; Encephalitis; Epilepsi | 1999 |
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins; | 2002 |