pk 11195 has been researched along with Drug Withdrawal Symptoms in 12 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we found that the translocator protein (18 kD) ligand XBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of sedation and tolerance development." | 5.14 | Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. ( Baghai, TC; Bertaina-Anglade, V; Chaperon, F; Eser, D; Floesser, A; Gentsch, C; Holsboer, F; Kalkman, HO; Kiese, B; Kucher, K; La Rochelle, CD; Landgraf, R; McAllister, KH; Nothdurfter, C; Rammes, G; Rupprecht, R; Schüle, C; Schumacher, M; Troxler, T; Tuerck, D; Uzunov, V, 2009) |
| " These results suggest that miltirone might ameliorate the symptoms associated with discontinuation of long-term administration of ethanol or of other positive modulators of the GABA(A) receptor." | 1.32 | Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons. ( Biggio, G; Busonero, F; Mascia, MP; Mostallino, MC; Pisu, MG; Talani, G, 2004) |
| "When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex." | 1.31 | The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. ( Holtman, JR; Jing, X; Sloan, JW; Wala, EP, 2000) |
| " FLU evoked dose-related tonic-clonic and clonic convulsions (five out of six rats), whereas PK (10 mg/kg) induced convulsions in only one rat (out of five); tachypnea tended to increase with the dose of both FLU and PK; twitches and jerks, backing and writhing had a significant regression on the dose of FLU; rearing tended to decrease with the dose of PK whereas FLU-evoked head bobbing and PK-evoked twitches and jerks had inverse U-shaped dose-response curves." | 1.30 | Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats. ( Jing, X; Sloan, JW; Wala, EP, 1997) |
| "[3H]PK 11195 binding was elevated in the liver (100%; P < 0." | 1.28 | Chronic ethanol consumption and withdrawal affects mitochondrial benzodiazepine receptors in rat brain and peripheral organs. ( Bidder, M; Fares, F; Gavish, M; Grel, I; Weizman, R, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rupprecht, R | 1 |
| Rammes, G | 1 |
| Eser, D | 1 |
| Baghai, TC | 1 |
| Schüle, C | 1 |
| Nothdurfter, C | 1 |
| Troxler, T | 1 |
| Gentsch, C | 1 |
| Kalkman, HO | 1 |
| Chaperon, F | 1 |
| Uzunov, V | 1 |
| McAllister, KH | 1 |
| Bertaina-Anglade, V | 1 |
| La Rochelle, CD | 1 |
| Tuerck, D | 1 |
| Floesser, A | 1 |
| Kiese, B | 1 |
| Schumacher, M | 1 |
| Landgraf, R | 1 |
| Holsboer, F | 1 |
| Kucher, K | 1 |
| Self, RL | 1 |
| Smith, KJ | 1 |
| Butler, TR | 1 |
| Pauly, JR | 1 |
| Prendergast, MA | 1 |
| Mostallino, MC | 1 |
| Mascia, MP | 1 |
| Pisu, MG | 1 |
| Busonero, F | 1 |
| Talani, G | 1 |
| Biggio, G | 1 |
| Byrnes, JJ | 1 |
| Miller, LG | 1 |
| Perkins, K | 1 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
| Wala, EP | 4 |
| Sloan, JW | 5 |
| Jing, X | 5 |
| Wala, E | 1 |
| Holtman, JR | 3 |
| Milliken, B | 1 |
| Bidder, M | 1 |
| Weizman, R | 2 |
| Fares, F | 1 |
| Grel, I | 1 |
| Gavish, M | 2 |
| Rägo, L | 1 |
| Saano, V | 1 |
| Auvinen, T | 1 |
| Adojaan, A | 1 |
| Holma, R | 1 |
| Airaksinen, MM | 1 |
| Tanne, Z | 1 |
| Granek, M | 1 |
| Karp, L | 1 |
| Golomb, M | 1 |
| Tyano, S | 1 |
1 trial available for pk 11195 and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.
Topics: Adult; Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Line; Drug Tolerance; gamma-A | 2009 |
11 other studies available for pk 11195 and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial
Topics: Animals; Autoradiography; Dizocilpine Maleate; Ethanol; Hippocampus; Injections, Intraventricular; I | 2009 |
Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Central Nervous System Depressants; Cerebral Cortex; | 2004 |
Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; GABA-A R | 1993 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Dr | 1997 |
Diazepam-treated female rats: flumazenil- and PK 11195-induced withdrawal in the hippocampus CA1.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Electroenceph | 1998 |
Substantia nigra: the involvement of central and peripheral benzodiazepine receptors in physical dependence on diazepam as evidenced by behavioral and EEG effects.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Behavior, Animal; Central Nervous System; Diaze | 1999 |
Precipitated withdrawal in the substantia nigra in diazepam-dependent female rats.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Electroencephalography; Female; Flumazenil; GAB | 1999 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazeni | 2000 |
Chronic ethanol consumption and withdrawal affects mitochondrial benzodiazepine receptors in rat brain and peripheral organs.
Topics: Alcohol Drinking; Animals; Brain; Ethanol; Heart; Isoquinolines; Liver; Male; Mitochondria; Myocardi | 1992 |
The effect of chronic treatment with peripheral benzodiazepine receptor ligands on behavior and GABAA/benzodiazepine receptors in rat.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Brain; Convulsants; Injections, Intraperitoneal; Isoqu | 1992 |
Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients.
Topics: Adult; Anxiety; Blood Platelets; Cell Membrane; Diazepam; Female; Humans; Isoquinolines; Kinetics; M | 1987 |