pk 11195 has been researched along with Disease Models, Animal in 74 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0 mm) alleviated the mechanical allodynia in neuropathic pain, while the TSPO inhibitor PK 11195 exacerbated it." | 3.83 | Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury. ( Hou, Y; Li, YF; Liu, FY; Liu, J; Wan, Y; Wu, H; Yi, M; Yin, Y; Zhang, M; Zheng, L; Zhou, MM, 2016) |
| "Besides, neuroinflammation has captured more attention in the process of HE, but the mechanism of neuroinflammation leading to HE remains unclear." | 2.52 | PET and MR imaging of neuroinflammation in hepatic encephalopathy. ( Lu, GM; Su, YY; Wu, S; Yang, GF; Zhang, LJ, 2015) |
| " Despite its use in clinical research, no studies on the imaging properties and pharmacokinetic analysis of (11)C-PBR28 in rodent models of neuroinflammation have been published yet." | 1.43 | Pharmacokinetic Analysis of 11C-PBR28 in the Rat Model of Herpes Encephalitis: Comparison with (R)-11C-PK11195. ( de Vries, EF; Dierckx, RA; Doorduin, J; Feltes, PK; Moriguchi Jeckel, CM; Parente, A; Sijbesma, JW; Vállez García, D, 2016) |
| "Also, depression is common in adults with type 2 diabetes mellitus (T2DM)." | 1.43 | The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. ( Chen, JS; He, JL; Liu, X; Nie, H; Qiu, ZK; Shen, YG; Zeng, J; Zhang, GH, 2016) |
| "Rats were subjected to permanent middle cerebral artery occlusion (pMCAO) by the macrosphere model and monitored by MRI and PET for 28 or 56 days, followed by immunohistochemical endpoint analysis." | 1.42 | In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. ( Backes, H; Fink, GR; Graf, R; Hoehn, M; Neumaier, B; Rueger, MA; Schroeter, M; Walberer, M; Walter, HL; Wiedermann, D, 2015) |
| "Midazolam is a short-acting benzodiazepine that is widely used as an i." | 1.38 | Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012) |
| " These results suggest that neither drug has therapeutic efficacy, however dosing and/or administration issues may have played a role." | 1.37 | Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury. ( Kelso, ML; Pauly, JR; Scheff, NN; Scheff, SW, 2011) |
| "Striatal gliosis induced by 3-NP treatment was prevented by (+/-)-huprine Y pretreatment, as demonstrated by the attenuation of both the increase in [(3)H]PK 11195 specific binding indicative of microgliosis and the expression of hsp27 kDa, a chaperone expressed mainly in astrocytes." | 1.32 | Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage. ( Camins, A; Camps, P; Canudas, AM; Jiménez, A; Muñoz-Torrero, D; Pallàs, M; Pubill, D; Sureda, FX; Verdaguer, E, 2003) |
| "Ferulic acid is a natural compound that expresses antioxidant and anti-inflammatory activities." | 1.32 | Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. ( Gasparini, L; Hauss-Wegrzyniak, B; Maucci, R; McGann-Gramling, K; Ongini, E; Ronchetti, D; Rosi, S; Wenk, GL, 2004) |
| "Pleurisy was induced by intrapleural injection of carrageenan in mice pre-treated or not with PK11195." | 1.32 | Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy. ( da Silva, MB; Farges, RC; Fröde, TS, 2004) |
| "Lifarizine was an effective neuroprotective agent in this model of focal ischaemia in the mouse." | 1.29 | Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia. ( Brown, CM; Calder, C; Kenny, BA; Linton, C; Patmore, L; Small, C; Spedding, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.35) | 18.7374 |
| 1990's | 8 (10.81) | 18.2507 |
| 2000's | 28 (37.84) | 29.6817 |
| 2010's | 35 (47.30) | 24.3611 |
| 2020's | 2 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 2 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Damont, A | 1 |
| Boisgard, R | 2 |
| Kuhnast, B | 2 |
| Lemée, F | 1 |
| Raggiri, G | 1 |
| Scarf, AM | 1 |
| Da Pozzo, E | 1 |
| Selleri, S | 1 |
| Martini, C | 1 |
| Tavitian, B | 3 |
| Kassiou, M | 2 |
| Dollé, F | 3 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Gao, ZW | 1 |
| Huang, YY | 1 |
| Zhang, JQ | 1 |
| Rong, JY | 1 |
| Qiao, GY | 1 |
| Chen, N | 1 |
| Yu, GD | 1 |
| Luo, M | 1 |
| Liu, XF | 1 |
| Kudryashov, NV | 1 |
| Kalinina, TS | 1 |
| Shimshirt, AA | 1 |
| Korolev, AO | 1 |
| Volkova, AV | 1 |
| Voronina, TA | 1 |
| Gong, Z | 1 |
| Han, Y | 1 |
| Wu, L | 1 |
| Xia, T | 1 |
| Ren, H | 1 |
| Yang, D | 1 |
| Gu, D | 1 |
| Wang, H | 1 |
| Hu, C | 1 |
| He, D | 1 |
| Zhou, L | 1 |
| Zeng, C | 1 |
| Boutin, H | 2 |
| Prenant, C | 1 |
| Maroy, R | 2 |
| Galea, J | 1 |
| Greenhalgh, AD | 1 |
| Smigova, A | 1 |
| Cawthorne, C | 1 |
| Julyan, P | 1 |
| Wilkinson, SM | 1 |
| Banister, SD | 1 |
| Brown, G | 1 |
| Herholz, K | 1 |
| Rothwell, NJ | 1 |
| Barron, AM | 1 |
| Garcia-Segura, LM | 1 |
| Caruso, D | 1 |
| Jayaraman, A | 1 |
| Lee, JW | 1 |
| Melcangi, RC | 1 |
| Pike, CJ | 1 |
| Agusti, A | 1 |
| Dziedzic, JL | 1 |
| Hernandez-Rabaza, V | 1 |
| Guilarte, TR | 2 |
| Felipo, V | 1 |
| Zhang, LM | 2 |
| Qiu, ZK | 3 |
| Zhao, N | 2 |
| Chen, HX | 2 |
| Liu, YQ | 1 |
| Xu, JP | 1 |
| Zhang, YZ | 2 |
| Yang, RF | 2 |
| Li, YF | 3 |
| Bogdanović, RM | 1 |
| Syvänen, S | 1 |
| Michler, C | 1 |
| Russmann, V | 1 |
| Eriksson, J | 1 |
| Windhorst, AD | 1 |
| Lammertsma, AA | 1 |
| de Lange, EC | 1 |
| Voskuyl, RA | 1 |
| Potschka, H | 1 |
| Walberer, M | 4 |
| Jantzen, SU | 2 |
| Backes, H | 5 |
| Rueger, MA | 3 |
| Keuters, MH | 1 |
| Neumaier, B | 5 |
| Hoehn, M | 4 |
| Fink, GR | 4 |
| Graf, R | 4 |
| Schroeter, M | 4 |
| Donat, CK | 1 |
| Fischer, F | 1 |
| Walter, B | 1 |
| Deuther-Conrad, W | 1 |
| Brodhun, M | 1 |
| Bauer, R | 1 |
| Brust, P | 1 |
| Su, YY | 1 |
| Yang, GF | 1 |
| Lu, GM | 1 |
| Wu, S | 1 |
| Zhang, LJ | 1 |
| Walter, HL | 1 |
| Wiedermann, D | 1 |
| Middleton, RJ | 1 |
| Liu, GJ | 1 |
| Banati, RB | 1 |
| Chen, XF | 1 |
| Xue, R | 1 |
| Parente, A | 1 |
| Feltes, PK | 1 |
| Vállez García, D | 1 |
| Sijbesma, JW | 1 |
| Moriguchi Jeckel, CM | 1 |
| Dierckx, RA | 1 |
| de Vries, EF | 1 |
| Doorduin, J | 1 |
| Ma, L | 1 |
| Zhang, H | 1 |
| Liu, N | 1 |
| Wang, PQ | 1 |
| Guo, WZ | 1 |
| Fu, Q | 1 |
| Jiao, LB | 1 |
| Ma, YQ | 1 |
| Mi, WD | 1 |
| Zhang, M | 1 |
| Liu, J | 1 |
| Zhou, MM | 1 |
| Wu, H | 1 |
| Hou, Y | 1 |
| Yin, Y | 1 |
| Zheng, L | 1 |
| Liu, FY | 1 |
| Yi, M | 1 |
| Wan, Y | 1 |
| Wang, DS | 1 |
| Han, J | 1 |
| Li, S | 1 |
| Sun, T | 1 |
| Guo, YY | 1 |
| Kang, WB | 1 |
| Tian, Z | 1 |
| Zhao, JN | 1 |
| Liu, G | 1 |
| Liu, SB | 1 |
| Zhao, MG | 1 |
| Ishikawa, M | 1 |
| Yoshitomi, T | 1 |
| Covey, DF | 1 |
| Zorumski, CF | 1 |
| Izumi, Y | 1 |
| He, JL | 1 |
| Liu, X | 1 |
| Zhang, GH | 1 |
| Zeng, J | 1 |
| Nie, H | 1 |
| Shen, YG | 1 |
| Chen, JS | 1 |
| Nozaki, S | 1 |
| Ozaki, N | 1 |
| Suzuki, S | 1 |
| Goto, M | 1 |
| Mawatari, A | 1 |
| Nakatani, Y | 1 |
| Hayashinaka, E | 1 |
| Wada, Y | 1 |
| Doi, H | 1 |
| Watanabe, Y | 1 |
| Arlicot, N | 1 |
| Katsifis, A | 2 |
| Garreau, L | 1 |
| Mattner, F | 2 |
| Vergote, J | 1 |
| Duval, S | 1 |
| Kousignian, I | 1 |
| Bodard, S | 2 |
| Guilloteau, D | 2 |
| Chalon, S | 2 |
| Toyama, H | 1 |
| Hatano, K | 1 |
| Suzuki, H | 1 |
| Ichise, M | 1 |
| Momosaki, S | 1 |
| Kudo, G | 1 |
| Ito, F | 1 |
| Kato, T | 1 |
| Yamaguchi, H | 1 |
| Katada, K | 1 |
| Sawada, M | 1 |
| Ito, K | 1 |
| Soustiel, JF | 1 |
| Zaaroor, M | 1 |
| Vlodavsky, E | 1 |
| Veenman, L | 1 |
| Weizman, A | 1 |
| Gavish, M | 1 |
| Visigalli, I | 1 |
| Moresco, RM | 1 |
| Belloli, S | 1 |
| Politi, LS | 1 |
| Gritti, A | 1 |
| Ungaro, D | 1 |
| Matarrese, M | 1 |
| Turolla, E | 1 |
| Falini, A | 1 |
| Scotti, G | 1 |
| Naldini, L | 1 |
| Fazio, F | 1 |
| Biffi, A | 1 |
| Dennin, MA | 1 |
| Kannan, S | 2 |
| Balakrishnan, B | 2 |
| Muzik, O | 3 |
| Romero, R | 2 |
| Chugani, D | 1 |
| Hirshler, YK | 1 |
| Polat, U | 1 |
| Biegon, A | 2 |
| Kelso, ML | 1 |
| Scheff, NN | 1 |
| Scheff, SW | 1 |
| Pauly, JR | 3 |
| Drouin-Ouellet, J | 1 |
| Brownell, AL | 1 |
| Saint-Pierre, M | 1 |
| Fasano, C | 1 |
| Emond, V | 1 |
| Trudeau, LE | 1 |
| Lévesque, D | 1 |
| Cicchetti, F | 1 |
| Saadani-Makki, F | 1 |
| Chakraborty, P | 2 |
| Janisse, J | 1 |
| Lu, X | 1 |
| Chugani, DC | 1 |
| Dhir, A | 1 |
| Rogawski, MA | 1 |
| van Bregt, DR | 1 |
| Thomas, TC | 2 |
| Hinzman, JM | 1 |
| Cao, T | 2 |
| Liu, M | 1 |
| Bing, G | 1 |
| Gerhardt, GA | 1 |
| Lifshitz, J | 2 |
| Ren, W | 1 |
| Jackson, N | 1 |
| Khoury, B | 1 |
| Shi, T | 1 |
| Flynn, JC | 1 |
| Markel, DC | 1 |
| Abourbeh, G | 1 |
| Thézé, B | 1 |
| Dubois, A | 2 |
| Brulon, V | 1 |
| Fontyn, Y | 1 |
| Muesken, S | 1 |
| Schnakenburg, K | 1 |
| Rapic, S | 1 |
| Viel, T | 1 |
| Kummer, MP | 1 |
| Monfared, P | 1 |
| Vollmar, S | 1 |
| Van der Linden, A | 1 |
| Heneka, MT | 1 |
| Jacobs, AH | 1 |
| Ziebell, JM | 1 |
| Wetter, JB | 1 |
| Jarvis, MF | 1 |
| Bitner, RS | 1 |
| Alvarado, M | 1 |
| Budinger, TF | 1 |
| Grossman, R | 1 |
| Hensley, K | 1 |
| West, MS | 1 |
| Kotake, Y | 1 |
| Ono, M | 1 |
| Floyd, RA | 1 |
| Bribes, E | 1 |
| Galiegue, S | 1 |
| Bourrie, B | 1 |
| Casellas, P | 1 |
| Bressan, E | 1 |
| Farges, RC | 3 |
| Ferrara, P | 2 |
| Tonussi, CR | 1 |
| Canudas, AM | 2 |
| Pubill, D | 2 |
| Sureda, FX | 2 |
| Verdaguer, E | 2 |
| Camps, P | 1 |
| Muñoz-Torrero, D | 1 |
| Jiménez, A | 1 |
| Camins, A | 2 |
| Pallàs, M | 2 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Wenk, GL | 1 |
| McGann-Gramling, K | 1 |
| Hauss-Wegrzyniak, B | 1 |
| Ronchetti, D | 1 |
| Maucci, R | 1 |
| Rosi, S | 1 |
| Gasparini, L | 1 |
| Ongini, E | 1 |
| da Silva, MB | 1 |
| Fröde, TS | 2 |
| Cornet, S | 1 |
| Spinnewyn, B | 1 |
| Delaflotte, S | 1 |
| Charnet, C | 1 |
| Roubert, V | 1 |
| Favre, C | 1 |
| Hider, H | 1 |
| Chabrier, PE | 1 |
| Auguet, M | 1 |
| Ryu, JK | 1 |
| Choi, HB | 1 |
| McLarnon, JG | 1 |
| Venneti, S | 3 |
| Lopresti, BJ | 2 |
| Wang, G | 3 |
| Slagel, SL | 1 |
| Mason, NS | 1 |
| Mathis, CA | 2 |
| Fischer, ML | 1 |
| Larsen, NJ | 1 |
| Mortimer, AD | 1 |
| Hastings, TG | 1 |
| Smith, AD | 1 |
| Zigmond, MJ | 1 |
| Suhara, T | 1 |
| Higuchi, M | 1 |
| Wiley, CA | 3 |
| Bartels, AL | 1 |
| Leenders, KL | 1 |
| Chauveau, F | 1 |
| Thominiaux, C | 1 |
| Grégoire, MC | 1 |
| Jan, S | 1 |
| Trebossen, R | 1 |
| Yanamoto, K | 1 |
| Zhang, MR | 1 |
| Kumata, K | 1 |
| Hatori, A | 1 |
| Okada, M | 1 |
| Suzuki, K | 1 |
| Chen, MK | 1 |
| Kuwabara, H | 1 |
| Zhou, Y | 1 |
| Adams, RJ | 1 |
| Brasić, JR | 1 |
| McGlothan, JL | 1 |
| Verina, T | 1 |
| Burton, NC | 1 |
| Alexander, M | 1 |
| Kumar, A | 1 |
| Wong, DF | 1 |
| Hamilton, RL | 1 |
| Klunk, WE | 1 |
| Apte, UM | 1 |
| Micale, V | 1 |
| Scapagnini, G | 1 |
| Colombrita, C | 1 |
| Mazzola, C | 1 |
| Alkon, DL | 1 |
| Drago, F | 1 |
| Wong, PT | 1 |
| Tan, CH | 1 |
| Kwan, MF | 1 |
| Ang, LK | 1 |
| Teo, WL | 1 |
| Rao, VL | 1 |
| Qureshi, IA | 1 |
| Butterworth, RF | 2 |
| Brown, CM | 1 |
| Calder, C | 1 |
| Linton, C | 1 |
| Small, C | 1 |
| Kenny, BA | 1 |
| Spedding, M | 1 |
| Patmore, L | 1 |
| Leong, DK | 1 |
| Oliva, L | 1 |
| Levivier, M | 1 |
| Przedborski, S | 1 |
| Waterfield, JD | 1 |
| McGeer, EG | 1 |
| McGeer, PL | 1 |
| Pellevoisin, C | 1 |
| Vilar, MP | 1 |
| Besnard, JC | 1 |
| Miyazawa, N | 1 |
| Saji, H | 1 |
| Takaishi, Y | 1 |
| Nukui, H | 1 |
| Torres, SR | 1 |
| Nardi, GM | 1 |
| Vita, N | 1 |
| Reeb, R | 1 |
| Ribeiro-do-Valle, RM | 1 |
| Raghavendra, V | 1 |
| Kaur, G | 1 |
| Kulkarni, SK | 1 |
| Escubedo, E | 1 |
| Camarasa, J | 1 |
| Benavides, J | 1 |
| Capdeville, C | 1 |
| Dauphin, F | 1 |
| Duverger, D | 1 |
| Fage, D | 1 |
| Gotti, B | 1 |
| MacKenzie, ET | 1 |
| Scatton, B | 1 |
| File, SE | 1 |
| Pellow, S | 1 |
4 reviews available for pk 11195 and Disease Models, Animal
| Article | Year |
|---|---|
PET and MR imaging of neuroinflammation in hepatic encephalopathy.
Topics: Amino Acid Transport System X-AG; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cytokines; Disea | 2015 |
Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Energy Metabolism; Inflamm | 2015 |
Positron emission tomography imaging of neuroinflammation.
Topics: Animals; Antineoplastic Agents; Brain Mapping; Carbon Isotopes; Disease Models, Animal; Encephalitis | 2009 |
Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Cytokines; Disease Models | 2007 |
70 other studies available for pk 11195 and Disease Models, Animal
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminopyridines; Animals; Corpu | 2011 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Disease Models, An | 2021 |
Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Fluoxetine; | 2018 |
Translocator protein 18 kDa ligand alleviates neointimal hyperplasia in the diabetic rat artery injury model via activating PKG.
Topics: Animals; Benzodiazepinones; Carotid Arteries; Carrier Proteins; Cell Movement; Cell Proliferation; C | 2019 |
[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; CD11b Antigen; Disease Models, Animal; Fluorin | 2013 |
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzodiazepinones | 2013 |
Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition.
Topics: Animals; Biomarkers; Brain; Carrier Proteins; Disease Models, Animal; Hepatic Encephalopathy; Imidaz | 2014 |
Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-traumatic stress disorder.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Disease Models, Animal; Dose-Response Relationsh | 2014 |
(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbon Radioisotopes; Carrier Proteins; Chronic Disease; Disease Mo | 2014 |
In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats.
Topics: Amyloid; Animals; Brain; Carbon Radioisotopes; Chronic Disease; Disease Models, Animal; Immunohistoc | 2014 |
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Brain Injuries; Cannabinoid | 2014 |
In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Brain Ischemia; Calcium-Bin | 2015 |
Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Isoquinolines; Mal | 2016 |
Pharmacokinetic Analysis of 11C-PBR28 in the Rat Model of Herpes Encephalitis: Comparison with (R)-11C-PK11195.
Topics: Animals; Biological Transport; Disease Models, Animal; Encephalitis, Herpes Simplex; Image Processin | 2016 |
TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Aspa | 2016 |
Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury.
Topics: Animals; Antineoplastic Agents; Bicuculline; Calcium-Binding Proteins; Carrier Proteins; Disease Mod | 2016 |
Antidepressant-Like and Anxiolytic-Like Effects of ZBD-2, a Novel Ligand for the Translocator Protein (18 kDa).
Topics: Acetamides; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depression; Disease Models | 2017 |
TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model.
Topics: 5-alpha Reductase Inhibitors; Animals; Carrier Proteins; Cholestenone 5 alpha-Reductase; Disease Mod | 2016 |
The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Carrier Proteins; Depression; Diabetes Mellitus, E | 2016 |
Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [
Topics: Animals; Arthritis, Rheumatoid; Carbon Radioisotopes; Disease Models, Animal; Female; Imaging, Three | 2017 |
Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Im | 2008 |
In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum.
Topics: Animals; Brain Injuries; Carrier Proteins; Corpus Striatum; Disease Models, Animal; Ethanol; Isoquin | 2008 |
Neuroprotective effect of Ro5-4864 following brain injury.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodiazepinones; Brain Injuries; Carrier Proteins; Casp | 2008 |
Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195.
Topics: Animals; Brain; Carbon Radioisotopes; Central Nervous System Diseases; Demyelinating Diseases; Disea | 2009 |
Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: a double tracer [11C]PK11195- and [18F]FDG-PET study.
Topics: Animals; Brain Infarction; Carbon Radioisotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Iso | 2009 |
Intracranial electrode implantation produces regional neuroinflammation and memory deficits in rats.
Topics: Analysis of Variance; Animals; Autoradiography; Brain; Deep Brain Stimulation; Disease Models, Anima | 2010 |
Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Avoidance Learning; Brain Injuries; Cerebral Cortex; D | 2011 |
Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.
Topics: Amphetamine; Animals; Animals, Newborn; Anti-Inflammatory Agents; Behavior, Animal; Cells, Cultured; | 2011 |
Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure.
Topics: Animals; Animals, Newborn; Antineoplastic Agents; Behavior, Animal; Brain; Carbon Radioisotopes; Cer | 2011 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani | 2012 |
Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atrophy; Brain Injuries; Calcium-Binding Proteins; Carrier | 2012 |
Differentiation of septic and aseptic loosening by PET with both 11C-PK11195 and 18F-FDG in rat models.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Agents; Arthroplast | 2012 |
Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [¹⁸F]DPA-714.
Topics: Animals; Antigens, CD; Carrier Proteins; Disease Models, Animal; Encephalomyelitis, Autoimmune, Expe | 2012 |
Effects of minocycline on endogenous neural stem cells after experimental stroke.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Anti-Bacterial Agents; Brain Infarction; Brain | 2012 |
Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2013 |
Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Calcium-Bind | 2012 |
Spinal microglial activation in rat models of neuropathic and osteoarthritic pain: an autoradiographic study using [3H]PK11195.
Topics: Animals; Autoradiography; Disease Models, Animal; Isoquinolines; Male; Microglia; Neuralgia; Osteoar | 2013 |
Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain.
Topics: Animals; Antioxidants; Autoradiography; Binding, Competitive; Brain; Cyclic N-Oxides; Disease Models | 2002 |
Involvement of the peripheral benzodiazepine receptor in the development of cutaneous pathology in Mrl/Lpr mice.
Topics: Animals; Antibodies, Blocking; Disease Models, Animal; GABA-A Receptor Agonists; Isoquinolines; Liga | 2003 |
Comparison of two PBR ligands with classical antiinflammatory drugs in LPS-induced arthritis in rats.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Benzodiazepinones; Carrageenan; Dexamethas | 2003 |
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Co | 2003 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Chronic Disease; Coumar | 2004 |
Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.
Topics: Adenosine Deaminase; Aminoglutethimide; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Ca | 2004 |
Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline.
Topics: Animals; Binding, Competitive; Brain Ischemia; Carrageenan; Corpus Striatum; Disease Models, Animal; | 2004 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.
Topics: Acetamides; Animals; Binding, Competitive; Brain; Disease Models, Animal; Encephalitis; Gliosis; Iso | 2007 |
In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.
Topics: Acetamides; Animals; Antineoplastic Agents; Binding, Competitive; Brain; Carbon Radioisotopes; Disea | 2007 |
Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Butadie | 2007 |
In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats.
Topics: Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Brain; Carbon Radioisotopes; | 2007 |
VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease.
Topics: Animals; Autoradiography; Brain; Carbon Isotopes; Carrier Proteins; Cocaine; Disease Models, Animal; | 2008 |
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocyt | 2009 |
Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents; Behavior, An | 2008 |
Effects of ethanol on peripheral benzodiazepine binding sites in the mouse cerebellum and brain stem.
Topics: Alcoholism; Animals; Benzodiazepines; Body Weight; Brain Stem; Cerebellum; Disease Models, Animal; D | 1995 |
Increased densities of binding sites for the peripheral-type benzodiazepine receptor ligand [3H]PK 11195 in congenital ornithine transcarbamylase-deficient sparse fur mouse.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Binding Sites; Brain; Disease Models, Animal | 1993 |
Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, D | 1995 |
Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: implications for positron emission tomography imaging.
Topics: Animals; Autoradiography; Brain; Brain Mapping; Disease Models, Animal; Flumazenil; GABA Modulators; | 1996 |
Quinolinic acid-induced lesions of the rat striatum: quantitative autoradiographic binding assessment.
Topics: Animals; Autoradiography; Benzazepines; Binding, Competitive; Cholinergic Agents; Corpus Striatum; D | 1998 |
The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Models, Animal; Female; GABA-A Recepto | 1999 |
Iodinated PK 11195 as an ex vivo marker of neuronal injury in the lesioned rat brain.
Topics: Animals; Autoradiography; Benzazepines; Brain; Brain Diseases; Disease Models, Animal; Iodine Radioi | 1996 |
Protective effect of FK506 in the reperfusion model after short-term occlusion of middle cerebral artery in the rat: assessment by autoradiography using [125I]PK-11195.
Topics: Animals; Autoradiography; Cerebral Infarction; Disease Models, Animal; Iodine Radioisotopes; Ischemi | 2000 |
Anti-inflammatory effects of peripheral benzodiazepine receptor ligands in two mouse models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Benzodiazepinones; Disease Models, Animal; | 2000 |
Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation.
Topics: Alprazolam; Analysis of Variance; Animals; Anti-Anxiety Agents; Antioxidants; Benzodiazepinones; Bic | 2000 |
Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Body Weight; Cell Survival; Cerebellum; Corpus | 2001 |
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.
Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Iso | 1990 |
The effects of PK 11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress.
Topics: Animals; Anxiety; Benzodiazepinones; Corticosterone; Disease Models, Animal; Drinking Behavior; Isoq | 1985 |