pk 11195 has been researched along with Disease Exacerbation in 12 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| " Tissue of 8 tumors was examined with immunohistochemistry markers for inflammation (Iba1), neoplastic cells (S-100 protein), vessels (CD31), the PK11195 target translocator protein (TSPO), fibrinogen for vascular permeability, and proliferation (Ki-67)." | 3.91 | Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma. ( Agushi, E; Atkinson, R; Coope, DJ; Evans, DG; Freeman, SR; Hammerbeck-Ward, C; Hinz, R; Hulme, S; Jackson, A; King, AT; Lewis, D; Li, KL; Lloyd, SKL; Mayers, H; Mosses, D; Pathmanaban, O; Roncaroli, F; Rutherford, SA; Stapleton, E; Wadeson, A; Williams, R; Zhu, X, 2019) |
| "Twenty-six (62%) of 42 mild cognitive impairment cases showed a raised cortical amyloid load compared to healthy controls." | 1.46 | Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease. ( Aanerud, J; Amidi, A; Borghammer, P; Brooks, DJ; Brændgaard, H; Edison, P; Eriksson, BO; Eskildsen, SF; Gottrup, H; Hansen, KV; Hinz, R; Ismail, R; Lund, TE; Mårup, FH; Parbo, P; Pavese, N; Stokholm, MG; Tietze, A, 2017) |
| "At baseline, patients with Alzheimer's disease showed significantly increased microglial activation compared to the control subjects." | 1.42 | Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease. ( Brooks, DJ; Edison, P; Fan, Z; Okello, AA, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sucksdorff, M | 1 |
| Matilainen, M | 1 |
| Tuisku, J | 2 |
| Polvinen, E | 1 |
| Vuorimaa, A | 1 |
| Rokka, J | 2 |
| Nylund, M | 1 |
| Rissanen, E | 2 |
| Airas, L | 2 |
| Parbo, P | 1 |
| Ismail, R | 1 |
| Hansen, KV | 1 |
| Amidi, A | 1 |
| Mårup, FH | 1 |
| Gottrup, H | 1 |
| Brændgaard, H | 1 |
| Eriksson, BO | 1 |
| Eskildsen, SF | 1 |
| Lund, TE | 1 |
| Tietze, A | 1 |
| Edison, P | 2 |
| Pavese, N | 2 |
| Stokholm, MG | 1 |
| Borghammer, P | 1 |
| Hinz, R | 2 |
| Aanerud, J | 1 |
| Brooks, DJ | 3 |
| Lewis, D | 1 |
| Roncaroli, F | 1 |
| Agushi, E | 1 |
| Mosses, D | 1 |
| Williams, R | 1 |
| Li, KL | 1 |
| Zhu, X | 1 |
| Atkinson, R | 1 |
| Wadeson, A | 1 |
| Hulme, S | 1 |
| Mayers, H | 1 |
| Stapleton, E | 1 |
| Lloyd, SKL | 1 |
| Freeman, SR | 1 |
| Rutherford, SA | 1 |
| Hammerbeck-Ward, C | 1 |
| Evans, DG | 1 |
| Pathmanaban, O | 1 |
| Jackson, A | 1 |
| King, AT | 1 |
| Coope, DJ | 1 |
| Wu, X | 1 |
| Gallo, KA | 1 |
| Paavilainen, T | 1 |
| Parkkola, R | 1 |
| Rinne, JO | 1 |
| Gent, YY | 2 |
| Ahmadi, N | 2 |
| Voskuyl, AE | 2 |
| Hoetjes, N | 1 |
| van Kuijk, C | 2 |
| Britsemmer, K | 1 |
| Turkstra, F | 1 |
| Boers, M | 2 |
| Hoekstra, OS | 2 |
| van der Laken, CJ | 2 |
| Ter Wee, MM | 1 |
| den Uyl, D | 1 |
| Dowling, C | 1 |
| Lems, WF | 1 |
| Fan, Z | 1 |
| Okello, AA | 1 |
| Wiley, CA | 2 |
| Lopresti, BJ | 2 |
| Venneti, S | 2 |
| Price, J | 1 |
| Klunk, WE | 2 |
| DeKosky, ST | 1 |
| Mathis, CA | 2 |
| Tai, YF | 1 |
| Gerhard, A | 2 |
| Tabrizi, SJ | 1 |
| Barker, RA | 1 |
| Piccini, P | 1 |
| Wang, G | 1 |
| Hamilton, RL | 1 |
| Apte, UM | 1 |
| Neumaier, B | 1 |
| Elitok, E | 1 |
| Glatting, G | 1 |
| Ries, V | 1 |
| Tomczak, R | 1 |
| Ludolph, AC | 1 |
| Reske, SN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Targeting of Sphingosine-1 Phosphate Receptors Reduce Microglial Activation in Multiple Sclerosis? A [11C]PK11195 Brain PET Study[NCT02139696] | 10 participants (Actual) | Observational | 2013-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 other studies available for pk 11195 and Disease Exacerbation
| Article | Year |
|---|---|
Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis.
Topics: Adult; Brain; Cohort Studies; Disability Evaluation; Disease Progression; Female; Humans; Isoquinoli | 2020 |
Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Case-Control Studies; Cerebr | 2017 |
Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma.
Topics: Adult; Aged; Aged, 80 and over; Calcium-Binding Proteins; Capillary Permeability; Carbon Radioisotop | 2019 |
The 18-kDa translocator protein (TSPO) disrupts mammary epithelial morphogenesis and promotes breast cancer cell migration.
Topics: Acinar Cells; Apoptosis; Benzodiazepinones; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell | 2013 |
In Vivo Detection of Diffuse Inflammation in Secondary Progressive Multiple Sclerosis Using PET Imaging and the Radioligand ¹¹C-PK11195.
Topics: Adult; Aged; Brain; Carbon Radioisotopes; Case-Control Studies; Disease Progression; Female; Humans; | 2014 |
Detection of subclinical synovitis with macrophage targeting and positron emission tomography in patients with rheumatoid arthritis without clinical arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cohort Studies; Contrast Media; Disease Progression; Female; Fin | 2014 |
Subclinical synovitis detected by macrophage PET, but not MRI, is related to short-term flare of clinical disease activity in early RA patients: an exploratory study.
Topics: Arthritis, Rheumatoid; Disease Progression; Female; Humans; Image Interpretation, Computer-Assisted; | 2015 |
Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Case-Control Studies; Disease Progressio | 2015 |
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antineoplastic | 2009 |
Microglial activation in presymptomatic Huntington's disease gene carriers.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Corpus Striatum; Disease Progression; F | 2007 |
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocyt | 2009 |
In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Ischemia; Carbon Radioisotopes; Cerebra | 2000 |