pk 11195 has been researched along with Depressive Disorder, Major in 3 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
Excerpt | Relevance | Reference |
---|---|---|
"Major depressive disorder is associated with raised peripheral inflammatory markers." | 1.48 | Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study. ( Anton-Rodriguez, JM; Conen, S; Gerhard, A; Gregory, CJ; Hinz, R; Holmes, SE; Matthews, JC; Talbot, PS, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (33.33) | 29.6817 |
2010's | 1 (33.33) | 24.3611 |
2020's | 1 (33.33) | 2.80 |
Authors | Studies |
---|---|
Schubert, JJ | 1 |
Veronese, M | 1 |
Fryer, TD | 1 |
Manavaki, R | 1 |
Kitzbichler, MG | 1 |
Nettis, MA | 1 |
Mondelli, V | 1 |
Pariante, CM | 1 |
Bullmore, ET | 1 |
Turkheimer, FE | 1 |
Holmes, SE | 1 |
Hinz, R | 1 |
Conen, S | 1 |
Gregory, CJ | 1 |
Matthews, JC | 1 |
Anton-Rodriguez, JM | 1 |
Gerhard, A | 1 |
Talbot, PS | 1 |
Chelli, B | 1 |
Pini, S | 1 |
Abelli, M | 1 |
Cardini, A | 1 |
Lari, L | 1 |
Muti, M | 1 |
Gesi, C | 1 |
Cassano, GB | 1 |
Lucacchini, A | 1 |
Martini, C | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Longitudinal Study of Inflammatory Pathways in Depression[NCT04159207] | 160 participants (Anticipated) | Observational | 2019-10-01 | Recruiting | |||
Naturalistic Monitoring of Microglial Activation in Inflammatory Bowel Disease[NCT03487926] | 135 participants (Anticipated) | Observational | 2022-09-14 | Active, not recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 other studies available for pk 11195 and Depressive Disorder, Major
Article | Year |
---|---|
A Modest Increase in
Topics: Body Mass Index; C-Reactive Protein; Depression; Depressive Disorder, Major; Humans; Isoquinolines; | 2021 |
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Depressive Disorder, Major; Female; Gyrus Cinguli; Human | 2018 |
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Depressive Disorder, Major; Female; Gyrus Cinguli; Human | 2018 |
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Depressive Disorder, Major; Female; Gyrus Cinguli; Human | 2018 |
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study.
Topics: Adult; Brain Mapping; Carbon Radioisotopes; Depressive Disorder, Major; Female; Gyrus Cinguli; Human | 2018 |
Platelet 18 kDa Translocator Protein density is reduced in depressed patients with adult separation anxiety.
Topics: Adult; Aged; Antineoplastic Agents; Anxiety, Separation; Blood Platelets; Depressive Disorder, Major | 2008 |