Page last updated: 2024-10-21

pk 11195 and Degenerative Diseases, Central Nervous System

pk 11195 has been researched along with Degenerative Diseases, Central Nervous System in 13 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Research Excerpts

ExcerptRelevanceReference
"In general, neurodegenerative diseases have unpredictable clinical courses and timely effective treatment is not available."2.43Nuclear imaging of inflammation in neurologic and psychiatric disorders. ( de Vries, EF; Dierckx, RA; Klein, HC, 2006)
"Striatal gliosis induced by 3-NP treatment was prevented by (+/-)-huprine Y pretreatment, as demonstrated by the attenuation of both the increase in [(3)H]PK 11195 specific binding indicative of microgliosis and the expression of hsp27 kDa, a chaperone expressed mainly in astrocytes."1.32Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage. ( Camins, A; Camps, P; Canudas, AM; Jiménez, A; Muñoz-Torrero, D; Pallàs, M; Pubill, D; Sureda, FX; Verdaguer, E, 2003)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (69.23)29.6817
2010's4 (30.77)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Scarf, AM1
Ittner, LM1
Kassiou, M1
Best, L1
Ghadery, C1
Pavese, N1
Tai, YF1
Strafella, AP1
Walberer, M1
Jantzen, SU1
Backes, H1
Rueger, MA1
Keuters, MH1
Neumaier, B1
Hoehn, M1
Fink, GR1
Graf, R1
Schroeter, M1
Milenkovic, VM1
Rupprecht, R1
Wetzel, CH1
Middleton, RJ1
Liu, GJ1
Banati, RB1
de Vries, EF1
Dierckx, RA1
Klein, HC1
Ouchi, Y1
Canudas, AM1
Pubill, D1
Sureda, FX1
Verdaguer, E1
Camps, P1
Muñoz-Torrero, D1
Jiménez, A1
Camins, A1
Pallàs, M1
Wilms, H1
Claasen, J1
Röhl, C1
Sievers, J1
Deuschl, G1
Lucius, R1
Belloli, S1
Moresco, RM1
Matarrese, M1
Biella, G1
Sanvito, F1
Simonelli, P1
Turolla, E1
Olivieri, S1
Cappelli, A1
Vomero, S1
Galli-Kienle, M1
Fazio, F1
Gerhard, A1
Trender-Gerhard, I1
Turkheimer, F1
Quinn, NP1
Bhatia, KP1
Brooks, DJ1
Maeda, J1
Higuchi, M1
Suhara, T1
Vas, A1
Shchukin, Y1
Karrenbauer, VD1
Cselényi, Z1
Kostulas, K1
Hillert, J1
Savic, I1
Takano, A1
Halldin, C1
Gulyás, B1

Reviews

7 reviews available for pk 11195 and Degenerative Diseases, Central Nervous System

ArticleYear
The translocator protein (18 kDa): central nervous system disease and drug design.
    Journal of medicinal chemistry, 2009, Feb-12, Volume: 52, Issue:3

    Topics: Acetamides; Apoptosis; Central Nervous System; Central Nervous System Diseases; Drug Design; Humans;

2009
New and Old TSPO PET Radioligands for Imaging Brain Microglial Activation in Neurodegenerative Disease.
    Current neurology and neuroscience reports, 2019, 04-02, Volume: 19, Issue:5

    Topics: Animals; Brain; Humans; Isoquinolines; Microglia; Neurodegenerative Diseases; Neuroimaging; Positron

2019
The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders.
    Mini reviews in medicinal chemistry, 2015, Volume: 15, Issue:5

    Topics: Antipsychotic Agents; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Isoquinol

2015
Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.
    Biochemical Society transactions, 2015, Volume: 43, Issue:4

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Energy Metabolism; Inflamm

2015
Nuclear imaging of inflammation in neurologic and psychiatric disorders.
    Current clinical pharmacology, 2006, Volume: 1, Issue:3

    Topics: Anti-Bacterial Agents; Antiviral Agents; Carbon Radioisotopes; Cyclooxygenase 2; Encephalitis; Human

2006
[Imaging of brain microgliosis by PET].
    Rinsho shinkeigaku = Clinical neurology, 2009, Volume: 49, Issue:11

    Topics: Animals; Brain; Carbon Radioisotopes; Cytokines; Humans; Isoquinolines; Mental Disorders; Microglia;

2009
[Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2006, Volume: 26, Issue:1

    Topics: Acetamides; Animals; Biomarkers; Carbon Radioisotopes; Gliosis; Humans; Isoquinolines; Ligands; Neur

2006

Trials

1 trial available for pk 11195 and Degenerative Diseases, Central Nervous System

ArticleYear
Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.
    Journal of the neurological sciences, 2008, Jan-15, Volume: 264, Issue:1-2

    Topics: Adult; Anticonvulsants; Antineoplastic Agents; Binding, Competitive; Biomarkers; Brain Mapping; Carb

2008

Other Studies

5 other studies available for pk 11195 and Degenerative Diseases, Central Nervous System

ArticleYear
In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats.
    Brain research, 2014, Sep-18, Volume: 1581

    Topics: Amyloid; Animals; Brain; Carbon Radioisotopes; Chronic Disease; Disease Models, Animal; Immunohistoc

2014
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
    Experimental neurology, 2003, Volume: 180, Issue:2

    Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Co

2003
Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro.
    Neurobiology of disease, 2003, Volume: 14, Issue:3

    Topics: Animals; Animals, Newborn; Benzodiazepines; Binding Sites; Cell Division; Cells, Cultured; Encephali

2003
Evaluation of three quinoline-carboxamide derivatives as potential radioligands for the in vivo pet imaging of neurodegeneration.
    Neurochemistry international, 2004, Volume: 44, Issue:6

    Topics: Amides; Animals; Immunohistochemistry; Isoquinolines; Ligands; Male; Neurodegenerative Diseases; Qui

2004
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.
    Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:1

    Topics: Aged; Basal Ganglia; Brain Stem; Carbon Radioisotopes; Cell Death; Female; Frontal Lobe; Humans; Ima

2006