pk 11195 has been researched along with Degenerative Diseases, Central Nervous System in 13 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "In general, neurodegenerative diseases have unpredictable clinical courses and timely effective treatment is not available." | 2.43 | Nuclear imaging of inflammation in neurologic and psychiatric disorders. ( de Vries, EF; Dierckx, RA; Klein, HC, 2006) |
| "Striatal gliosis induced by 3-NP treatment was prevented by (+/-)-huprine Y pretreatment, as demonstrated by the attenuation of both the increase in [(3)H]PK 11195 specific binding indicative of microgliosis and the expression of hsp27 kDa, a chaperone expressed mainly in astrocytes." | 1.32 | Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage. ( Camins, A; Camps, P; Canudas, AM; Jiménez, A; Muñoz-Torrero, D; Pallàs, M; Pubill, D; Sureda, FX; Verdaguer, E, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scarf, AM | 1 |
| Ittner, LM | 1 |
| Kassiou, M | 1 |
| Best, L | 1 |
| Ghadery, C | 1 |
| Pavese, N | 1 |
| Tai, YF | 1 |
| Strafella, AP | 1 |
| Walberer, M | 1 |
| Jantzen, SU | 1 |
| Backes, H | 1 |
| Rueger, MA | 1 |
| Keuters, MH | 1 |
| Neumaier, B | 1 |
| Hoehn, M | 1 |
| Fink, GR | 1 |
| Graf, R | 1 |
| Schroeter, M | 1 |
| Milenkovic, VM | 1 |
| Rupprecht, R | 1 |
| Wetzel, CH | 1 |
| Middleton, RJ | 1 |
| Liu, GJ | 1 |
| Banati, RB | 1 |
| de Vries, EF | 1 |
| Dierckx, RA | 1 |
| Klein, HC | 1 |
| Ouchi, Y | 1 |
| Canudas, AM | 1 |
| Pubill, D | 1 |
| Sureda, FX | 1 |
| Verdaguer, E | 1 |
| Camps, P | 1 |
| Muñoz-Torrero, D | 1 |
| Jiménez, A | 1 |
| Camins, A | 1 |
| Pallàs, M | 1 |
| Wilms, H | 1 |
| Claasen, J | 1 |
| Röhl, C | 1 |
| Sievers, J | 1 |
| Deuschl, G | 1 |
| Lucius, R | 1 |
| Belloli, S | 1 |
| Moresco, RM | 1 |
| Matarrese, M | 1 |
| Biella, G | 1 |
| Sanvito, F | 1 |
| Simonelli, P | 1 |
| Turolla, E | 1 |
| Olivieri, S | 1 |
| Cappelli, A | 1 |
| Vomero, S | 1 |
| Galli-Kienle, M | 1 |
| Fazio, F | 1 |
| Gerhard, A | 1 |
| Trender-Gerhard, I | 1 |
| Turkheimer, F | 1 |
| Quinn, NP | 1 |
| Bhatia, KP | 1 |
| Brooks, DJ | 1 |
| Maeda, J | 1 |
| Higuchi, M | 1 |
| Suhara, T | 1 |
| Vas, A | 1 |
| Shchukin, Y | 1 |
| Karrenbauer, VD | 1 |
| Cselényi, Z | 1 |
| Kostulas, K | 1 |
| Hillert, J | 1 |
| Savic, I | 1 |
| Takano, A | 1 |
| Halldin, C | 1 |
| Gulyás, B | 1 |
7 reviews available for pk 11195 and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
The translocator protein (18 kDa): central nervous system disease and drug design.
Topics: Acetamides; Apoptosis; Central Nervous System; Central Nervous System Diseases; Drug Design; Humans; | 2009 |
New and Old TSPO PET Radioligands for Imaging Brain Microglial Activation in Neurodegenerative Disease.
Topics: Animals; Brain; Humans; Isoquinolines; Microglia; Neurodegenerative Diseases; Neuroimaging; Positron | 2019 |
The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders.
Topics: Antipsychotic Agents; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Isoquinol | 2015 |
Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Energy Metabolism; Inflamm | 2015 |
Nuclear imaging of inflammation in neurologic and psychiatric disorders.
Topics: Anti-Bacterial Agents; Antiviral Agents; Carbon Radioisotopes; Cyclooxygenase 2; Encephalitis; Human | 2006 |
[Imaging of brain microgliosis by PET].
Topics: Animals; Brain; Carbon Radioisotopes; Cytokines; Humans; Isoquinolines; Mental Disorders; Microglia; | 2009 |
[Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands].
Topics: Acetamides; Animals; Biomarkers; Carbon Radioisotopes; Gliosis; Humans; Isoquinolines; Ligands; Neur | 2006 |
1 trial available for pk 11195 and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Binding, Competitive; Biomarkers; Brain Mapping; Carb | 2008 |
5 other studies available for pk 11195 and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats.
Topics: Amyloid; Animals; Brain; Carbon Radioisotopes; Chronic Disease; Disease Models, Animal; Immunohistoc | 2014 |
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Co | 2003 |
Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro.
Topics: Animals; Animals, Newborn; Benzodiazepines; Binding Sites; Cell Division; Cells, Cultured; Encephali | 2003 |
Evaluation of three quinoline-carboxamide derivatives as potential radioligands for the in vivo pet imaging of neurodegeneration.
Topics: Amides; Animals; Immunohistochemistry; Isoquinolines; Ligands; Male; Neurodegenerative Diseases; Qui | 2004 |
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.
Topics: Aged; Basal Ganglia; Brain Stem; Carbon Radioisotopes; Cell Death; Female; Frontal Lobe; Humans; Ima | 2006 |