pk 11195 has been researched along with Common Migraine in 1 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "The kinetic parameters at equilibrium of peripheral benzodiazepine receptors in platelets, lymphocytes and granulocytes of 15 patients affected by migraine without aura were tested using [3H]PK 11195, a specific radioligand for this receptor and compared with the same number of healthy controls: a statistically significant increase (platelets 212%, lymphocytes 203%, granulocytes 171%, as absolute percentage) in the maximal number of binding sites (B(max)) in all three patient samples, compared with healthy controls was detected; on the contrary, the values of the dissociation constant (K(d)) at equilibrium do not show any statistically significant variations between the two groups." | 3.70 | Peripheral-type benzodiazepine receptors in human blood cells of patients affected by migraine without aura. ( Betti, L; Bonanni, E; Bonuccelli, U; Ferrari, S; Giannaccini, G; Lucacchini, A; Murri, L; Pavese, N, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pavese, N | 1 |
| Giannaccini, G | 1 |
| Betti, L | 1 |
| Ferrari, S | 1 |
| Bonanni, E | 1 |
| Bonuccelli, U | 1 |
| Murri, L | 1 |
| Lucacchini, A | 1 |
1 other study available for pk 11195 and Common Migraine
| Article | Year |
|---|---|
Peripheral-type benzodiazepine receptors in human blood cells of patients affected by migraine without aura.
Topics: Adult; Blood Platelets; Cell Membrane; Female; Granulocytes; Humans; Isoquinolines; Lymphocytes; Mal | 2000 |