pk 11195 has been researched along with Colorectal Neoplasms in 2 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| " FGIN-1-27 but not PK 11195-induced apoptosis was associated with a decrease of mitochondrial membrane potential and an increase of mitochondrial volume in HT29 colorectal cancer cells." | 3.73 | Mechanisms of mitochondrial apoptosis induced by peripheral benzodiazepine receptor ligands in human colorectal cancer cells. ( Maaser, K; Scherübl, H; Sutter, AP, 2005) |
| "Although colorectal cancers were found to overexpress PBR, the functional role of PBR in colorectal cancer growth has not been addressed to date." | 1.31 | Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. ( Carayon, P; Gavish, M; Höpfner, M; Jansen, A; Kozikowski, AP; Maaser, K; Riecken, EO; Scherübl, H; Weisinger, G; Weizman, A; Zeitz, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maaser, K | 2 |
| Sutter, AP | 1 |
| Scherübl, H | 2 |
| Höpfner, M | 1 |
| Jansen, A | 1 |
| Weisinger, G | 1 |
| Gavish, M | 1 |
| Kozikowski, AP | 1 |
| Weizman, A | 1 |
| Carayon, P | 1 |
| Riecken, EO | 1 |
| Zeitz, M | 1 |
2 other studies available for pk 11195 and Colorectal Neoplasms
| Article | Year |
|---|---|
Mechanisms of mitochondrial apoptosis induced by peripheral benzodiazepine receptor ligands in human colorectal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Caspases; Cell Line, Tumor; | 2005 |
Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells.
Topics: Adult; Aged; Apoptosis; Benzodiazepinones; Cell Cycle; Colorectal Neoplasms; Dose-Response Relations | 2001 |