pk 11195 has been researched along with Cognitive Decline in 7 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is an organ dysfunction caused by a host's unregulated response to infection, causing long-term brain dysfunction with microglial activation, the release of inflammatory components, and mitochondrial changes." | 1.62 | The Protective Effect of PK-11195 on Cognitive Impairment in Rats Survived of Polymicrobial Sepsis. ( Abatti, MR; Barichello, T; Dal-Pizzol, F; Dominguini, D; Generoso, JS; Steckert, AV, 2021) |
| "Twenty-six (62%) of 42 mild cognitive impairment cases showed a raised cortical amyloid load compared to healthy controls." | 1.46 | Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease. ( Aanerud, J; Amidi, A; Borghammer, P; Brooks, DJ; Brændgaard, H; Edison, P; Eriksson, BO; Eskildsen, SF; Gottrup, H; Hansen, KV; Hinz, R; Ismail, R; Lund, TE; Mårup, FH; Parbo, P; Pavese, N; Stokholm, MG; Tietze, A, 2017) |
| "10 AD, 10 mild cognitive impairment (MCI), 11 PD dementia (PDD), and 16 controls underwent magnetic resonance imaging, [11C](R)PK11195 (1-[2-chlorophenyl]-N-methyl-N-[1-methyl-propyl]-3-isoquinoline carboxamide), [11C]PIB (11C-Pittsburgh compound B), [18F]FDG-PET (18F-2-fluoro-2-deoxyglucose positron emission tomography) scans." | 1.42 | Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia. ( Ahmed, I; Aman, Y; Brooks, DJ; Chetelat, G; Edison, P; Fan, Z; Landeau, B; Ray Chaudhuri, K, 2015) |
| "Data from controls, mild cognitive impairment patients, and patients with Alzheimer's disease were analyzed using various kinetic models including plasma input, the simplified reference tissue model (RPM) and RPM with vascular correction (RPMV(b))." | 1.38 | Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies. ( Boellaard, R; Hinz, R; Lammertsma, AA; Schuitemaker, A; Tomasi, G; Turkheimer, FE; van Berckel, BN; Yaqub, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Parbo, P | 2 |
| Madsen, LS | 1 |
| Ismail, R | 2 |
| Zetterberg, H | 1 |
| Blennow, K | 1 |
| Eskildsen, SF | 2 |
| Vorup-Jensen, T | 1 |
| Brooks, DJ | 4 |
| Stær, K | 1 |
| Iranzo, A | 1 |
| Stokholm, MG | 2 |
| Østergaard, K | 1 |
| Serradell, M | 1 |
| Otto, M | 1 |
| Svendsen, KB | 1 |
| Garrido, A | 1 |
| Vilas, D | 1 |
| Santamaria, J | 1 |
| Møller, A | 1 |
| Gaig, C | 1 |
| Borghammer, P | 2 |
| Tolosa, E | 1 |
| Pavese, N | 2 |
| Dominguini, D | 1 |
| Steckert, AV | 1 |
| Abatti, MR | 1 |
| Generoso, JS | 1 |
| Barichello, T | 1 |
| Dal-Pizzol, F | 1 |
| Tondo, G | 1 |
| Boccalini, C | 1 |
| Caminiti, SP | 1 |
| Presotto, L | 1 |
| Filippi, M | 1 |
| Magnani, G | 1 |
| Frisoni, GB | 1 |
| Iannaccone, S | 1 |
| Perani, D | 1 |
| Hansen, KV | 1 |
| Amidi, A | 1 |
| Mårup, FH | 1 |
| Gottrup, H | 1 |
| Brændgaard, H | 1 |
| Eriksson, BO | 1 |
| Lund, TE | 1 |
| Tietze, A | 1 |
| Edison, P | 2 |
| Hinz, R | 2 |
| Aanerud, J | 1 |
| Fan, Z | 1 |
| Aman, Y | 1 |
| Ahmed, I | 1 |
| Chetelat, G | 1 |
| Landeau, B | 1 |
| Ray Chaudhuri, K | 1 |
| Yaqub, M | 1 |
| van Berckel, BN | 1 |
| Schuitemaker, A | 1 |
| Turkheimer, FE | 1 |
| Tomasi, G | 1 |
| Lammertsma, AA | 1 |
| Boellaard, R | 1 |
7 other studies available for pk 11195 and Cognitive Decline
| Article | Year |
|---|---|
Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Carbon Radioisotopes; Cognitive Dysfunction; Female; Humans; In | 2020 |
Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder.
Topics: Acetylcholinesterase; Aged; Carbon Radioisotopes; Cerebral Cortex; Cholinesterase Inhibitors; Cognit | 2020 |
The Protective Effect of PK-11195 on Cognitive Impairment in Rats Survived of Polymicrobial Sepsis.
Topics: Animals; Brain; Cognitive Dysfunction; Cytokines; Isoquinolines; Male; Microglia; Neuroprotective Ag | 2021 |
Brain Metabolism and Microglia Activation in Mild Cognitive Impairment: A Combined [18F]FDG and [11C]-(R)-PK11195 PET Study.
Topics: Aged; Brain; Brain Mapping; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Glucose; Humans; | 2021 |
Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Case-Control Studies; Cerebr | 2017 |
Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia.
Topics: Alzheimer Disease; Amyloid; Brain; Brain Mapping; Carbon Radioisotopes; Cognitive Dysfunction; Fluor | 2015 |
Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Alzheimer Disease; Blood Volume; Carbon Radioisotopes; C | 2012 |