Page last updated: 2024-10-21

pk 11195 and Chronic Illness

pk 11195 has been researched along with Chronic Illness in 10 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Research Excerpts

ExcerptRelevanceReference
"Rats were subjected to permanent middle cerebral artery occlusion (pMCAO) by the macrosphere model and monitored by MRI and PET for 28 or 56 days, followed by immunohistochemical endpoint analysis."1.42In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. ( Backes, H; Fink, GR; Graf, R; Hoehn, M; Neumaier, B; Rueger, MA; Schroeter, M; Walberer, M; Walter, HL; Wiedermann, D, 2015)
"Ferulic acid is a natural compound that expresses antioxidant and anti-inflammatory activities."1.32Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. ( Gasparini, L; Hauss-Wegrzyniak, B; Maucci, R; McGann-Gramling, K; Ongini, E; Ronchetti, D; Rosi, S; Wenk, GL, 2004)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's7 (70.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kaunzner, UW1
Kang, Y1
Zhang, S1
Morris, E1
Yao, Y1
Pandya, S1
Hurtado Rua, SM1
Park, C1
Gillen, KM1
Nguyen, TD1
Wang, Y1
Pitt, D1
Gauthier, SA1
Bogdanović, RM1
Syvänen, S1
Michler, C1
Russmann, V1
Eriksson, J1
Windhorst, AD1
Lammertsma, AA1
de Lange, EC1
Voskuyl, RA1
Potschka, H1
Walberer, M2
Jantzen, SU1
Backes, H2
Rueger, MA2
Keuters, MH1
Neumaier, B2
Hoehn, M2
Fink, GR2
Graf, R2
Schroeter, M2
Walter, HL1
Wiedermann, D1
Hunter, HJ1
Hinz, R1
Gerhard, A1
Talbot, PS1
Su, Z1
Holland, G1
Hopkins, SJ1
Griffiths, CE1
Kleyn, CE1
Garvey, LJ1
Pavese, N1
Ramlackhansingh, A1
Thomson, E1
Allsop, JM1
Politis, M1
Kulasegaram, R1
Main, J1
Brooks, DJ1
Taylor-Robinson, SD1
Winston, A1
Tegler, G1
Sörensen, J1
Ericson, K1
Björck, M1
Wanhainen, A1
Wenk, GL1
McGann-Gramling, K1
Hauss-Wegrzyniak, B1
Ronchetti, D1
Maucci, R1
Rosi, S1
Gasparini, L1
Ongini, E1
Kurumaji, A1
Wakai, T1
Toru, M1
Perney, P1
Butterworth, RF1
Mousseau, DD1
Lavoie, J1
Fabbro-Peray, P1
Blanc, F1
Layrargues, GP1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Safety and Efficacy of Subcutaneous Cladribine for Nonrelapsing, Secondary Progressive Multiple Sclerosis (CLASP-MS): a Randomized, Placebo-controlled, Double-blind, Phase 2 Study.[NCT05961644]Phase 2/Phase 3188 participants (Anticipated)Interventional2022-10-03Recruiting
Evaluation of the Degree of Demyelination and Remyelination in Multiple Sclerosis (MS) Detected by Brain Positron Emission Tomography With Amyloid Markers (PET-CT 18F-Florbetaben) and Comparison With MRI Findings[NCT05783934]20 participants (Anticipated)Interventional2021-07-27Recruiting
A Prospective Case-control Study to Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-infection - a PET Study[NCT00959166]81 participants (Actual)Interventional2009-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Association of 11C-labelled PK11195 Uptake Using PET With Acute HCV and HIV Infection

Association of 11C-labelled PK11195 uptake using PET with acute HCV and HIV infection by PK11195 PET ligand binding. The ligand PK11195 is selective for the peripheral benzodiazepine binding site and exhibits minimal binding in normal brain. In brain lesions, however, there is a massive increase in binding. (NCT00959166)
Timeframe: 30 days

Interventionbinding potential ratio (Mean)
HIV/Acute HCV Coinfection0.18
HIV Mono0.22

Ratio of NAA/Cr (N-acetyl Aspartate/Creatine) Cerebral Metabolites

"Association between patient characteristics and 11C-labelled PK11195 uptake using PET, CNS metabolite ratios.~By quantifying the surrogate markers of N-acetylaspartate (NAA), creatine (Cr) offers insight into the neuronal integrity, cell membrane synthesis and turnover, macrophage infiltration, inflammation status, and levels of microglial activation and gliosis within the sampled CNS tissue." (NCT00959166)
Timeframe: 30 days

Interventionratio (Mean)
HIV/Acute HCV Coinfection1.42
HIV Mono1.35

Other Studies

10 other studies available for pk 11195 and Chronic Illness

ArticleYear
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
    Brain : a journal of neurology, 2019, 01-01, Volume: 142, Issue:1

    Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C

2019
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
    Brain : a journal of neurology, 2019, 01-01, Volume: 142, Issue:1

    Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C

2019
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
    Brain : a journal of neurology, 2019, 01-01, Volume: 142, Issue:1

    Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C

2019
Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.
    Brain : a journal of neurology, 2019, 01-01, Volume: 142, Issue:1

    Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Carbon Radioisotopes; C

2019
(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.
    Neuropharmacology, 2014, Volume: 85

    Topics: Animals; Anticonvulsants; Brain; Carbon Radioisotopes; Carrier Proteins; Chronic Disease; Disease Mo

2014
In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats.
    Brain research, 2014, Sep-18, Volume: 1581

    Topics: Amyloid; Animals; Brain; Carbon Radioisotopes; Chronic Disease; Disease Models, Animal; Immunohistoc

2014
In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke.
    Neuroscience, 2015, Apr-30, Volume: 292

    Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Brain Ischemia; Calcium-Bin

2015
Brain inflammation and psoriasis: a [
    The British journal of dermatology, 2016, Volume: 175, Issue:5

    Topics: Adolescent; Adult; Carbon Radioisotopes; Chronic Disease; Encephalitis; Female; Humans; Isoquinoline

2016
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Acute Disease; Adult; Biological Transport; Carbon Radioisotopes; Case-Control Studies; Cerebral Cor

2012
4D-PET/CT with [(11)C]-PK11195 and [(11)C]-(D)-deprenyl does not identify the chronic inflammation in asymptomatic abdominal aortic aneurysms.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2013, Volume: 45, Issue:4

    Topics: Aged; Aortic Aneurysm, Abdominal; Aortitis; Asymptomatic Diseases; Biopsy; Carbon Radioisotopes; Chr

2013
Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid.
    Journal of neurochemistry, 2004, Volume: 89, Issue:2

    Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Chronic Disease; Coumar

2004
Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics.
    Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:11-12

    Topics: Adult; Aged; Brain; Brain Chemistry; Chronic Disease; Female; Humans; Isoquinolines; Kinetics; Male;

1997
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
    Metabolic brain disease, 1998, Volume: 13, Issue:3

    Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clo

1998