pk 11195 has been researched along with Chemical Dependence in 6 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex." | 1.31 | The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. ( Holtman, JR; Jing, X; Sloan, JW; Wala, EP, 2000) |
| " FLU evoked dose-related tonic-clonic and clonic convulsions (five out of six rats), whereas PK (10 mg/kg) induced convulsions in only one rat (out of five); tachypnea tended to increase with the dose of both FLU and PK; twitches and jerks, backing and writhing had a significant regression on the dose of FLU; rearing tended to decrease with the dose of PK whereas FLU-evoked head bobbing and PK-evoked twitches and jerks had inverse U-shaped dose-response curves." | 1.30 | Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats. ( Jing, X; Sloan, JW; Wala, EP, 1997) |
| "Stanozolol was the most effective inhibitor, reducing [3H] PK11195 binding by up to 75%, compared to only 40% inhibition by 17beta-cyp, at 50 microM AAS concentration." | 1.29 | Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse. ( Masonis, AE; McCarthy, MP, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Masonis, AE | 1 |
| McCarthy, MP | 1 |
| Wala, EP | 4 |
| Sloan, JW | 4 |
| Jing, X | 4 |
| Holtman, JR | 2 |
| Syapin, PJ | 1 |
| Alkana, RL | 1 |
6 other studies available for pk 11195 and Chemical Dependence
| Article | Year |
|---|---|
Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse.
Topics: Anabolic Agents; Animals; Brain; GABA-A Receptor Agonists; In Vitro Techniques; Isoquinolines; Male; | 1996 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Dr | 1997 |
Substantia nigra: the involvement of central and peripheral benzodiazepine receptors in physical dependence on diazepam as evidenced by behavioral and EEG effects.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Behavior, Animal; Central Nervous System; Diaze | 1999 |
Precipitated withdrawal in the substantia nigra in diazepam-dependent female rats.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Electroencephalography; Female; Flumazenil; GAB | 1999 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazeni | 2000 |
Chronic ethanol exposure increases peripheral-type benzodiazepine receptors in brain.
Topics: Animals; Benzodiazepinones; Brain; Convulsants; Diet; Ethanol; Isoquinolines; Kinetics; Male; Mice; | 1988 |