pk 11195 has been researched along with Cerebral Hemorrhage in 3 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Such focal brain inflammation aggravates secondary brain injury by exacerbating blood-brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death." | 2.61 | Global brain inflammation in stroke. ( Ducruet, AF; Lawton, MT; Li, ZG; Shi, FD; Shi, K; Tian, DC, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abid, KA | 1 |
| Sobowale, OA | 1 |
| Parkes, LM | 1 |
| Naish, J | 1 |
| Parker, GJM | 1 |
| du Plessis, D | 1 |
| Brough, D | 1 |
| Barrington, J | 1 |
| Allan, SM | 1 |
| Hinz, R | 1 |
| Parry-Jones, AR | 1 |
| Shi, K | 1 |
| Tian, DC | 1 |
| Li, ZG | 1 |
| Ducruet, AF | 1 |
| Lawton, MT | 1 |
| Shi, FD | 1 |
| Rojas, S | 1 |
| Martín, A | 1 |
| Arranz, MJ | 1 |
| Pareto, D | 1 |
| Purroy, J | 1 |
| Verdaguer, E | 1 |
| Llop, J | 1 |
| Gómez, V | 1 |
| Gispert, JD | 1 |
| Millán, O | 1 |
| Chamorro, A | 1 |
| Planas, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke: A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Phase III Trial[NCT05836740] | Phase 3 | 1,672 participants (Anticipated) | Interventional | 2023-05-19 | Recruiting | ||
| Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy: A Phase II, Randomized, Multicenter, Double-blind, Single Dose, Placebo-controlled Parallel Trial[NCT05836753] | Phase 2 | 120 participants (Anticipated) | Interventional | 2023-05-07 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pk 11195 and Cerebral Hemorrhage
| Article | Year |
|---|---|
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
2 other studies available for pk 11195 and Cerebral Hemorrhage
| Article | Year |
|---|---|
Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI.
Topics: Adult; Aged, 80 and over; Brain; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Female; Humans; H | 2018 |
Imaging brain inflammation with [(11)C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats.
Topics: Animals; Autoradiography; Blotting, Western; Brain; Cerebral Hemorrhage; Cerebral Infarction; Image | 2007 |