pk 11195 has been researched along with Cancer of Ovary in 4 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Endometrial and ovarian cancer cells were treated with various concentrations of PK11195 alone or in combination with chemotherapeutic drugs (cisplatin, paclitaxel), and its effect on cell growth, the cell cycle, apoptosis and related measurements was investigated." | 1.36 | PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells. ( Narahara, H; Nasu, K; Nishida, M; Takai, N; Ueda, T, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takai, N | 1 |
| Ueda, T | 1 |
| Nishida, M | 1 |
| Nasu, K | 1 |
| Narahara, H | 1 |
| Jakubikova, J | 1 |
| Duraj, J | 1 |
| Hunakova, L | 1 |
| Chorvath, B | 1 |
| Sedlak, J | 1 |
| Batra, S | 1 |
| Iosif, CS | 1 |
| Katz, Y | 1 |
| Ben-Baruch, G | 1 |
| Kloog, Y | 1 |
| Menczer, J | 1 |
| Gavish, M | 1 |
4 other studies available for pk 11195 and Cancer of Ovary
| Article | Year |
|---|---|
PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell L | 2010 |
PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biologica | 2002 |
Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors.
Topics: Adult; Aged; Binding Sites; Electron Transport Complex IV; Female; Humans; Isoquinolines; Kinetics; | 1998 |
Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries.
Topics: Adenocarcinoma, Papillary; Adult; Aged; Benzodiazepines; Binding Sites; Female; Humans; Isoquinoline | 1990 |