pk 11195 has been researched along with Brain Neoplasms in 21 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Meningioma is one of the common brain tumors in adults." | 5.43 | The effects of PK11195 on meningioma was associated with allopregnanolone biosynthesis, which was mediated by translocator protein 18 KDa. ( Gao, ZW; Huang, JB; Liang, YJ; Lin, Q; Luo, M; Qin, Q; Zhou, L, 2016) |
| "Binding of the isoquinoline PK 11195 and of the benzodiazepines Ro5-4864 and flunitrazepam was compared in glioma cells and tissues." | 3.67 | Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. ( Junck, L; Mancini, WR; Olson, JM; Penney, JB; Young, AB, 1988) |
| "Meningioma is one of the common brain tumors in adults." | 1.43 | The effects of PK11195 on meningioma was associated with allopregnanolone biosynthesis, which was mediated by translocator protein 18 KDa. ( Gao, ZW; Huang, JB; Liang, YJ; Lin, Q; Luo, M; Qin, Q; Zhou, L, 2016) |
| "TSPO in gliomas was expressed predominantly by neoplastic cells, and its expression correlated positively with BPND in the tumors." | 1.42 | The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study. ( Brodbelt, A; Coope, DJ; Du Plessis, D; Durrenberger, PF; Gerhard, A; Herholz, K; Hinz, R; Jackson, A; Janczar, K; Karabatsou, K; Roncaroli, F; Su, Z; Thompson, G; Turkheimer, FE, 2015) |
| "We examined two anaplastic astrocytomas showing minimal contrast-enhancement and therefore little damage of the blood brain barrier to minimise the presence of blood borne macrophages within tumour tissue." | 1.34 | The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. ( Akiyama, H; Banati, RB; Deprez, M; Fukuyama, H; Hashikawa, K; Ishizu, K; Kawashima, H; Mottram, N; Roncaroli, F; Takaya, S; Turkheimer, FE, 2007) |
| " These studies consisted of single-dose and steady-state dosing regimen studies, the latter to assess drug distribution in normal brain and brain tumors." | 1.31 | Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model. ( Adams, AL; Gallo, JM; Guo, P; Guo, Z; Li, S; Ma, J, 2001) |
| "C6 glioma has a KD significantly greater than rat cortex." | 1.28 | Autoradiographic study of peripheral benzodiazepine receptors in animal brain tumor models and human gliomas. ( Diksic, M; Mitsuka, S; Takada, A; Yamamoto, YL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castellano, S | 1 |
| Taliani, S | 1 |
| Viviano, M | 1 |
| Milite, C | 1 |
| Da Pozzo, E | 1 |
| Costa, B | 1 |
| Barresi, E | 1 |
| Bruno, A | 1 |
| Cosconati, S | 1 |
| Marinelli, L | 1 |
| Greco, G | 1 |
| Novellino, E | 1 |
| Sbardella, G | 1 |
| Da Settimo, F | 1 |
| Martini, C | 1 |
| Denora, N | 1 |
| Lee, C | 1 |
| Iacobazzi, RM | 1 |
| Choi, JY | 1 |
| Song, IH | 1 |
| Yoo, JS | 1 |
| Piao, Y | 1 |
| Lopalco, A | 1 |
| Leonetti, F | 1 |
| Lee, BC | 1 |
| Kim, SE | 1 |
| Su, Z | 1 |
| Roncaroli, F | 2 |
| Durrenberger, PF | 1 |
| Coope, DJ | 1 |
| Karabatsou, K | 1 |
| Hinz, R | 1 |
| Thompson, G | 1 |
| Turkheimer, FE | 2 |
| Janczar, K | 1 |
| Du Plessis, D | 1 |
| Brodbelt, A | 1 |
| Jackson, A | 1 |
| Gerhard, A | 1 |
| Herholz, K | 1 |
| Gao, ZW | 1 |
| Huang, JB | 1 |
| Lin, Q | 1 |
| Qin, Q | 1 |
| Liang, YJ | 1 |
| Zhou, L | 1 |
| Luo, M | 1 |
| Crossley, EL | 1 |
| Issa, F | 1 |
| Scarf, AM | 1 |
| Kassiou, M | 1 |
| Rendina, LM | 1 |
| Dehnhardt, M | 1 |
| Palm, C | 1 |
| Vieten, A | 1 |
| Bauer, A | 1 |
| Pietrzyk, U | 1 |
| Takaya, S | 1 |
| Hashikawa, K | 1 |
| Mottram, N | 1 |
| Deprez, M | 1 |
| Ishizu, K | 1 |
| Kawashima, H | 1 |
| Akiyama, H | 1 |
| Fukuyama, H | 1 |
| Banati, RB | 1 |
| Ikezaki, K | 4 |
| Nomura, T | 1 |
| Takahashi, M | 1 |
| Fritz-Zieroth, B | 1 |
| Inamura, T | 1 |
| Fukui, M | 1 |
| Miyazawa, N | 1 |
| Hamel, E | 1 |
| Diksic, M | 2 |
| Guo, P | 1 |
| Ma, J | 1 |
| Li, S | 1 |
| Guo, Z | 1 |
| Adams, AL | 1 |
| Gallo, JM | 1 |
| Takada, A | 1 |
| Mitsuka, S | 1 |
| Yamamoto, YL | 1 |
| Cornu, P | 3 |
| Benavides, J | 3 |
| Scatton, B | 3 |
| Hauw, JJ | 3 |
| Philippon, J | 1 |
| Pappata, S | 1 |
| Samson, Y | 1 |
| Prenant, C | 1 |
| Crouzel, C | 1 |
| Syrota, A | 1 |
| Black, KL | 3 |
| Santori, E | 1 |
| Becker, DP | 2 |
| Vinters, HV | 1 |
| Santori, EM | 1 |
| Smith, ML | 1 |
| Payne, BA | 1 |
| Toga, AW | 2 |
| Broaddus, WC | 1 |
| Bennett, JP | 1 |
| Gildersleeve, DL | 1 |
| Lin, TY | 1 |
| Wieland, DM | 1 |
| Ciliax, BJ | 1 |
| Olson, JM | 2 |
| Young, AB | 2 |
| Ferrarese, C | 1 |
| Appollonio, I | 1 |
| Frigo, M | 1 |
| Gaini, SM | 1 |
| Piolti, R | 1 |
| Frattola, L | 1 |
| Dennis, T | 1 |
| Dubois, A | 1 |
| MacKenzie, ET | 1 |
| Sazdovitch, V | 1 |
| Junck, L | 1 |
| Penney, JB | 1 |
| Mancini, WR | 1 |
21 other studies available for pk 11195 and Brain Neoplasms
| Article | Year |
|---|---|
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Computational Biol | 2014 |
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging.
Topics: Animals; Brain Neoplasms; Carbocyanines; Cell Line; Cell Survival; Ferric Compounds; Fluorescent Dye | 2019 |
The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Biomarkers, Tumor; Blood-Brain Barrier; Brain; Brain Neop | 2015 |
The effects of PK11195 on meningioma was associated with allopregnanolone biosynthesis, which was mediated by translocator protein 18 KDa.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Isoquin | 2016 |
Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells.
Topics: Antineoplastic Agents; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Line, T | 2011 |
Quantifying the A1AR distribution in peritumoural zones around experimental F98 and C6 rat brain tumours.
Topics: Animals; Astrocytoma; Autoradiography; Brain Neoplasms; Caudate Nucleus; Cell Line, Tumor; Image Pro | 2007 |
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
Topics: Adult; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Female; Humans; Image Processing, Compu | 2007 |
Selective and prolonged MRI enhancement by Mn-TPPS in an experimental rat brain tumour with peripheral benzodiazepine receptors.
Topics: Animals; Brain Neoplasms; Clonazepam; Contrast Media; Glioma; Isoquinolines; Kidney; Magnetic Resona | 1994 |
Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods.
Topics: Astrocytoma; Autoradiography; Biomarkers, Tumor; Brain Neoplasms; Cell Differentiation; Glioma; Huma | 1998 |
Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Deoxycytidine; Drug Delivery Systems; Gem | 2001 |
Autoradiographic study of peripheral benzodiazepine receptors in animal brain tumor models and human gliomas.
Topics: Animals; Autoradiography; Brain; Brain Neoplasms; Glioma; Humans; Isoquinolines; Kinetics; Rats; Rat | 1992 |
Increase in omega 3 (peripheral-type benzodiazepine) binding site densities in different types of human brain tumours. A quantitative autoradiography study.
Topics: Astrocytoma; Autoradiography; Biomarkers, Tumor; Brain; Brain Neoplasms; Cerebellar Neoplasms; Gliom | 1992 |
PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report.
Topics: Aged; Brain Neoplasms; Carbon Radioisotopes; Glioblastoma; Humans; Isoquinolines; Male; Receptors, G | 1991 |
Specific high-affinity binding of peripheral benzodiazepine receptor ligands to brain tumors in rat and man.
Topics: Animals; Autoradiography; Brain Neoplasms; Humans; Isoquinolines; Rats; Rats, Inbred Strains; Recept | 1990 |
Three-dimensional comparison of peripheral benzodiazepine binding and histological findings in rat brain tumor.
Topics: Animals; Brain Neoplasms; Female; Flunitrazepam; Glioma; Isoquinolines; Rats; Rats, Inbred Strains; | 1990 |
Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.
Topics: Affinity Labels; Benzodiazepinones; Binding, Competitive; Brain Neoplasms; Cerebral Cortex; Glioma; | 1990 |
Imaging of brain tumors using peripheral benzodiazepine receptor ligands.
Topics: Animals; Autoradiography; Brain Neoplasms; Clonazepam; Female; Flunitrazepam; Glioma; Image Processi | 1989 |
Synthesis of a high specific activity 125I-labeled analog of PK 11195, potential agent for SPECT imaging of the peripheral benzodiazepine binding site.
Topics: Animals; Brain Neoplasms; Chromatography, High Pressure Liquid; Glioma; Humans; In Vitro Techniques; | 1989 |
Benzodiazepine receptors and diazepam-binding inhibitor in human cerebral tumors.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Diazepam Binding Inhibitor; Female; Fl | 1989 |
Imaging of human brain lesions with an omega 3 site radioligand.
Topics: Adult; Aged; Autoradiography; Brain; Brain Ischemia; Brain Neoplasms; Glioblastoma; Humans; Isoquino | 1988 |
Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging.
Topics: Benzodiazepines; Benzodiazepinones; Brain Neoplasms; Cells, Cultured; Flunitrazepam; Glioma; Humans; | 1988 |