Page last updated: 2024-10-21

pk 11195 and Brain Ischemia

pk 11195 has been researched along with Brain Ischemia in 25 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
" We have evaluated by positron emission tomography the time course of changes in brain uptake in vivo of 11C-labeled PK 11195 and flumazenil (an antagonist of central benzodiazepine receptors) as indirect and direct markers of neuronal loss, respectively, after focal cerebral ischemia."3.68In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon. ( Baron, JC; Barré, L; Derlon, JM; MacKenzie, ET; Miyazawa, H; Sette, G; Tillet, I; Travère, JM; Young, AR, 1993)
"Such focal brain inflammation aggravates secondary brain injury by exacerbating blood-brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death."2.61Global brain inflammation in stroke. ( Ducruet, AF; Lawton, MT; Li, ZG; Shi, FD; Shi, K; Tian, DC, 2019)
"Rats were subjected to permanent middle cerebral artery occlusion (pMCAO) by the macrosphere model and monitored by MRI and PET for 28 or 56 days, followed by immunohistochemical endpoint analysis."1.42In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. ( Backes, H; Fink, GR; Graf, R; Hoehn, M; Neumaier, B; Rueger, MA; Schroeter, M; Walberer, M; Walter, HL; Wiedermann, D, 2015)
"Cerebral ischemia was induced by permanent occlusion of left middle cerebral artery."1.29GM1 reduces infarct volume after focal cerebral ischemia. ( Koga, T; Lazzaro, A; Manev, H; Schiavo, N; Seren, MS; Zanoni, R, 1994)
"When given after the induction of cerebral ischemia, the NMDA receptor antagonists dizocilpine and CGS 19755 and the mixed NMDA antagonist/sigma ligand eliprodil (SL 82."1.28Lack of neuroprotective effect of some sigma ligands in a model of focal cerebral ischemia in the mouse. ( Nowicki, JP; Poignet, H; Scatton, B, 1992)
"PK 11195 is a selective ligand for the peripheral-type benzodiazepine binding site (PTBBS)."1.28The distribution of radioactivity in brains of rats given [N-methyl-11C]PK 11195 in vivo after induction of a cortical ischaemic lesion. ( Bateman, DM; Cremer, JE; Cullen, BM; Hume, SP; Luthra, SK; Manjil, LG; Myers, R; Pike, VW; Turton, DR, 1992)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.00)18.7374
1990's9 (36.00)18.2507
2000's9 (36.00)29.6817
2010's5 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shi, K1
Tian, DC1
Li, ZG1
Ducruet, AF1
Lawton, MT1
Shi, FD1
Boutin, H1
Prenant, C1
Maroy, R1
Galea, J1
Greenhalgh, AD1
Smigova, A1
Cawthorne, C1
Julyan, P1
Wilkinson, SM1
Banister, SD1
Brown, G1
Herholz, K1
Kassiou, M1
Rothwell, NJ1
Walter, HL1
Walberer, M1
Rueger, MA1
Backes, H1
Wiedermann, D1
Hoehn, M1
Neumaier, B2
Graf, R1
Fink, GR1
Schroeter, M1
Cao, YL1
Chen, CF1
Wang, AW1
Feng, YB1
Cheng, HX1
Zhang, WW1
Xin, W1
Moraga, A1
Gómez-Vallejo, V1
Cuartero, MI1
Szczupak, B1
San Sebastián, E1
Markuerkiaga, I1
Pradillo, JM1
Higuchi, M1
Llop, J1
Moro, MÁ1
Martín, A1
Lizasoain, I1
Katchanov, J1
Waeber, C1
Gertz, K1
Gietz, A1
Winter, B1
Brück, W1
Dirnagl, U1
Veh, RW1
Endres, M1
Cornet, S1
Spinnewyn, B1
Delaflotte, S1
Charnet, C1
Roubert, V1
Favre, C1
Hider, H1
Chabrier, PE1
Auguet, M1
Gerhard, A2
Schwarz, J1
Myers, R5
Wise, R1
Banati, RB2
Price, CJ1
Wang, D1
Menon, DK1
Guadagno, JV1
Cleij, M1
Fryer, T1
Aigbirhio, F1
Baron, JC2
Warburton, EA1
Imaizumi, M1
Kim, HJ1
Zoghbi, SS1
Briard, E1
Hong, J1
Musachio, JL1
Ruetzler, C1
Chuang, DM1
Pike, VW2
Innis, RB1
Fujita, M1
Benavides, J4
Dubois, A4
Scatton, B5
Sette, G1
Young, AR1
Miyazawa, H1
Tillet, I1
Barré, L1
Travère, JM1
Derlon, JM1
MacKenzie, ET4
Lazzaro, A1
Seren, MS1
Koga, T1
Zanoni, R1
Schiavo, N1
Manev, H1
Kenny, BA1
MacKinnon, AC1
Spedding, M1
Brown, CM1
Zouakia, A1
Guilloteau, D1
Zimmer, L1
Besnard, JC1
Chalon, S1
Elitok, E1
Glatting, G1
Ries, V1
Tomczak, R1
Ludolph, AC1
Reske, SN1
Pappata, S1
Levasseur, M1
Gunn, RN1
Crouzel, C1
Syrota, A1
Jones, T1
Kreutzberg, GW1
Rao, VL1
Bowen, KK1
Rao, AM1
Dempsey, RJ1
Ramsay, SC1
Weiller, C1
Cremer, JE3
Luthra, SK2
Lammertsma, AA1
Frackowiak, RS2
Poignet, H1
Nowicki, JP1
Hume, SP1
Cullen, BM1
Manjil, LG2
Turton, DR1
Bateman, DM1
Capdeville, C1
Dauphin, F1
Duverger, D2
Fage, D2
Gotti, B2
Peny, B1
Cornu, P1
Dennis, T1
Hauw, JJ1
Sazdovitch, V1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke: A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Phase III Trial[NCT05836740]Phase 31,672 participants (Anticipated)Interventional2023-05-19Recruiting
Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy: A Phase II, Randomized, Multicenter, Double-blind, Single Dose, Placebo-controlled Parallel Trial[NCT05836753]Phase 2120 participants (Anticipated)Interventional2023-05-07Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for pk 11195 and Brain Ischemia

ArticleYear
Global brain inflammation in stroke.
    The Lancet. Neurology, 2019, Volume: 18, Issue:11

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma

2019
Global brain inflammation in stroke.
    The Lancet. Neurology, 2019, Volume: 18, Issue:11

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma

2019
Global brain inflammation in stroke.
    The Lancet. Neurology, 2019, Volume: 18, Issue:11

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma

2019
Global brain inflammation in stroke.
    The Lancet. Neurology, 2019, Volume: 18, Issue:11

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma

2019

Other Studies

24 other studies available for pk 11195 and Brain Ischemia

ArticleYear
[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; CD11b Antigen; Disease Models, Animal; Fluorin

2013
In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke.
    Neuroscience, 2015, Apr-30, Volume: 292

    Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Brain Ischemia; Calcium-Bin

2015
Changes of peripheral-type benzodiazepine receptors in the penumbra area after cerebral ischemia-reperfusion injury and effects of astragaloside IV on rats.
    Genetics and molecular research : GMR, 2015, Jan-23, Volume: 14, Issue:1

    Topics: Animals; Brain; Brain Ischemia; Female; Isoquinolines; Male; Mitochondria; Rats, Sprague-Dawley; Rec

2015
Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016, Volume: 36, Issue:4

    Topics: Animals; Brain Ischemia; Cell Proliferation; Cerebral Arterial Diseases; Cerebral Infarction; Dideox

2016
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
    Brain pathology (Zurich, Switzerland), 2003, Volume: 13, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit

2003
Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline.
    European journal of pharmacology, 2004, Nov-28, Volume: 505, Issue:1-3

    Topics: Animals; Binding, Competitive; Brain Ischemia; Carrageenan; Corpus Striatum; Disease Models, Animal;

2004
Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study.
    NeuroImage, 2005, Jan-15, Volume: 24, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Brain Mapping; Brain Stem; Carbon Radioisotopes; Cer

2005
Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.
    Stroke, 2006, Volume: 37, Issue:7

    Topics: Acute Disease; Adult; Aged; Brain Ischemia; Carbon Radioisotopes; Female; Humans; Infarction, Middle

2006
PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat.
    Neuroscience letters, 2007, Jan-16, Volume: 411, Issue:3

    Topics: Acetamides; Animals; Autoradiography; Brain Ischemia; Carbon Isotopes; Image Processing, Computer-As

2007
Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury.
    Current protocols in neuroscience, 2001, Volume: Chapter 7

    Topics: Animals; Autoradiography; Biomarkers; Brain Chemistry; Brain Injuries; Brain Ischemia; Carrier Prote

2001
In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon.
    Stroke, 1993, Volume: 24, Issue:12

    Topics: Animals; Brain Ischemia; Brain Mapping; Cerebral Infarction; Flumazenil; Isoquinolines; Macrophages;

1993
GM1 reduces infarct volume after focal cerebral ischemia.
    Experimental neurology, 1994, Volume: 125, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Edema; Brain Ischemia; Caudate Nucleus; Cerebral Infa

1994
Changes in [3H]-PK 11195 and [3H]-8-OH-DPAT binding following forebrain ischaemia in the gerbil.
    British journal of pharmacology, 1993, Volume: 109, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Benzodiazepines; Benzodiazepinones

1993
Evolution of dopamine receptors in the rat after neonatal hypoxia-ischemia: autoradiographic studies.
    Life sciences, 1997, Volume: 60, Issue:2

    Topics: Animals; Animals, Newborn; Autoradiography; Brain Ischemia; Corpus Striatum; Hypoxia; Iodine Radiois

1997
In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke.
    Neuroreport, 2000, Sep-11, Volume: 11, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Ischemia; Carbon Radioisotopes; Cerebra

2000
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.
    Neurology, 2000, Oct-10, Volume: 55, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Carbon Radioisotopes; Female; Humans; Isoquinolines;

2000
Up-regulation of the peripheral-type benzodiazepine receptor expression and [(3)H]PK11195 binding in gerbil hippocampus after transient forebrain ischemia.
    Journal of neuroscience research, 2001, Jun-01, Volume: 64, Issue:5

    Topics: Animals; Antineoplastic Agents; Binding Sites; Brain Ischemia; Gene Expression Regulation; Gerbillin

2001
Monitoring by PET of macrophage accumulation in brain after ischaemic stroke.
    Lancet (London, England), 1992, Apr-25, Volume: 339, Issue:8800

    Topics: Brain Ischemia; Carbon Radioisotopes; Humans; Isoquinolines; Macrophages; Male; Middle Aged; Tomogra

1992
Lack of neuroprotective effect of some sigma ligands in a model of focal cerebral ischemia in the mouse.
    Brain research, 1992, Nov-20, Volume: 596, Issue:1-2

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Dose-Response Relationship, Drug; Guanidines; Isoquinoline

1992
The distribution of radioactivity in brains of rats given [N-methyl-11C]PK 11195 in vivo after induction of a cortical ischaemic lesion.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1992, Volume: 19, Issue:2

    Topics: Animals; Autoradiography; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebral Cortex; Isoquinoline

1992
[3H]PK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex.
    Neuroscience letters, 1991, Nov-25, Volume: 133, Issue:1

    Topics: Animals; Autoradiography; Brain Ischemia; Immunohistochemistry; Isoquinolines; Male; Motor Cortex; R

1991
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.
    Brain research, 1990, Jul-09, Volume: 522, Issue:2

    Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Iso

1990
Imaging of primary and remote ischaemic and excitotoxic brain lesions. An autoradiographic study of peripheral type benzodiazepine binding sites in the rat and cat.
    Brain research, 1988, Mar-29, Volume: 445, Issue:1

    Topics: Animals; Autoradiography; Benzazepines; Brain; Brain Ischemia; Cerebral Arteries; Dopamine Antagonis

1988
Imaging of human brain lesions with an omega 3 site radioligand.
    Annals of neurology, 1988, Volume: 24, Issue:6

    Topics: Adult; Aged; Autoradiography; Brain; Brain Ischemia; Brain Neoplasms; Glioblastoma; Humans; Isoquino

1988