pk 11195 has been researched along with Brain Ischemia in 25 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have evaluated by positron emission tomography the time course of changes in brain uptake in vivo of 11C-labeled PK 11195 and flumazenil (an antagonist of central benzodiazepine receptors) as indirect and direct markers of neuronal loss, respectively, after focal cerebral ischemia." | 3.68 | In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon. ( Baron, JC; Barré, L; Derlon, JM; MacKenzie, ET; Miyazawa, H; Sette, G; Tillet, I; Travère, JM; Young, AR, 1993) |
| "Such focal brain inflammation aggravates secondary brain injury by exacerbating blood-brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death." | 2.61 | Global brain inflammation in stroke. ( Ducruet, AF; Lawton, MT; Li, ZG; Shi, FD; Shi, K; Tian, DC, 2019) |
| "Rats were subjected to permanent middle cerebral artery occlusion (pMCAO) by the macrosphere model and monitored by MRI and PET for 28 or 56 days, followed by immunohistochemical endpoint analysis." | 1.42 | In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. ( Backes, H; Fink, GR; Graf, R; Hoehn, M; Neumaier, B; Rueger, MA; Schroeter, M; Walberer, M; Walter, HL; Wiedermann, D, 2015) |
| "Cerebral ischemia was induced by permanent occlusion of left middle cerebral artery." | 1.29 | GM1 reduces infarct volume after focal cerebral ischemia. ( Koga, T; Lazzaro, A; Manev, H; Schiavo, N; Seren, MS; Zanoni, R, 1994) |
| "When given after the induction of cerebral ischemia, the NMDA receptor antagonists dizocilpine and CGS 19755 and the mixed NMDA antagonist/sigma ligand eliprodil (SL 82." | 1.28 | Lack of neuroprotective effect of some sigma ligands in a model of focal cerebral ischemia in the mouse. ( Nowicki, JP; Poignet, H; Scatton, B, 1992) |
| "PK 11195 is a selective ligand for the peripheral-type benzodiazepine binding site (PTBBS)." | 1.28 | The distribution of radioactivity in brains of rats given [N-methyl-11C]PK 11195 in vivo after induction of a cortical ischaemic lesion. ( Bateman, DM; Cremer, JE; Cullen, BM; Hume, SP; Luthra, SK; Manjil, LG; Myers, R; Pike, VW; Turton, DR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, K | 1 |
| Tian, DC | 1 |
| Li, ZG | 1 |
| Ducruet, AF | 1 |
| Lawton, MT | 1 |
| Shi, FD | 1 |
| Boutin, H | 1 |
| Prenant, C | 1 |
| Maroy, R | 1 |
| Galea, J | 1 |
| Greenhalgh, AD | 1 |
| Smigova, A | 1 |
| Cawthorne, C | 1 |
| Julyan, P | 1 |
| Wilkinson, SM | 1 |
| Banister, SD | 1 |
| Brown, G | 1 |
| Herholz, K | 1 |
| Kassiou, M | 1 |
| Rothwell, NJ | 1 |
| Walter, HL | 1 |
| Walberer, M | 1 |
| Rueger, MA | 1 |
| Backes, H | 1 |
| Wiedermann, D | 1 |
| Hoehn, M | 1 |
| Neumaier, B | 2 |
| Graf, R | 1 |
| Fink, GR | 1 |
| Schroeter, M | 1 |
| Cao, YL | 1 |
| Chen, CF | 1 |
| Wang, AW | 1 |
| Feng, YB | 1 |
| Cheng, HX | 1 |
| Zhang, WW | 1 |
| Xin, W | 1 |
| Moraga, A | 1 |
| Gómez-Vallejo, V | 1 |
| Cuartero, MI | 1 |
| Szczupak, B | 1 |
| San Sebastián, E | 1 |
| Markuerkiaga, I | 1 |
| Pradillo, JM | 1 |
| Higuchi, M | 1 |
| Llop, J | 1 |
| Moro, MÁ | 1 |
| Martín, A | 1 |
| Lizasoain, I | 1 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Cornet, S | 1 |
| Spinnewyn, B | 1 |
| Delaflotte, S | 1 |
| Charnet, C | 1 |
| Roubert, V | 1 |
| Favre, C | 1 |
| Hider, H | 1 |
| Chabrier, PE | 1 |
| Auguet, M | 1 |
| Gerhard, A | 2 |
| Schwarz, J | 1 |
| Myers, R | 5 |
| Wise, R | 1 |
| Banati, RB | 2 |
| Price, CJ | 1 |
| Wang, D | 1 |
| Menon, DK | 1 |
| Guadagno, JV | 1 |
| Cleij, M | 1 |
| Fryer, T | 1 |
| Aigbirhio, F | 1 |
| Baron, JC | 2 |
| Warburton, EA | 1 |
| Imaizumi, M | 1 |
| Kim, HJ | 1 |
| Zoghbi, SS | 1 |
| Briard, E | 1 |
| Hong, J | 1 |
| Musachio, JL | 1 |
| Ruetzler, C | 1 |
| Chuang, DM | 1 |
| Pike, VW | 2 |
| Innis, RB | 1 |
| Fujita, M | 1 |
| Benavides, J | 4 |
| Dubois, A | 4 |
| Scatton, B | 5 |
| Sette, G | 1 |
| Young, AR | 1 |
| Miyazawa, H | 1 |
| Tillet, I | 1 |
| Barré, L | 1 |
| Travère, JM | 1 |
| Derlon, JM | 1 |
| MacKenzie, ET | 4 |
| Lazzaro, A | 1 |
| Seren, MS | 1 |
| Koga, T | 1 |
| Zanoni, R | 1 |
| Schiavo, N | 1 |
| Manev, H | 1 |
| Kenny, BA | 1 |
| MacKinnon, AC | 1 |
| Spedding, M | 1 |
| Brown, CM | 1 |
| Zouakia, A | 1 |
| Guilloteau, D | 1 |
| Zimmer, L | 1 |
| Besnard, JC | 1 |
| Chalon, S | 1 |
| Elitok, E | 1 |
| Glatting, G | 1 |
| Ries, V | 1 |
| Tomczak, R | 1 |
| Ludolph, AC | 1 |
| Reske, SN | 1 |
| Pappata, S | 1 |
| Levasseur, M | 1 |
| Gunn, RN | 1 |
| Crouzel, C | 1 |
| Syrota, A | 1 |
| Jones, T | 1 |
| Kreutzberg, GW | 1 |
| Rao, VL | 1 |
| Bowen, KK | 1 |
| Rao, AM | 1 |
| Dempsey, RJ | 1 |
| Ramsay, SC | 1 |
| Weiller, C | 1 |
| Cremer, JE | 3 |
| Luthra, SK | 2 |
| Lammertsma, AA | 1 |
| Frackowiak, RS | 2 |
| Poignet, H | 1 |
| Nowicki, JP | 1 |
| Hume, SP | 1 |
| Cullen, BM | 1 |
| Manjil, LG | 2 |
| Turton, DR | 1 |
| Bateman, DM | 1 |
| Capdeville, C | 1 |
| Dauphin, F | 1 |
| Duverger, D | 2 |
| Fage, D | 2 |
| Gotti, B | 2 |
| Peny, B | 1 |
| Cornu, P | 1 |
| Dennis, T | 1 |
| Hauw, JJ | 1 |
| Sazdovitch, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke: A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Phase III Trial[NCT05836740] | Phase 3 | 1,672 participants (Anticipated) | Interventional | 2023-05-19 | Recruiting | ||
| Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy: A Phase II, Randomized, Multicenter, Double-blind, Single Dose, Placebo-controlled Parallel Trial[NCT05836753] | Phase 2 | 120 participants (Anticipated) | Interventional | 2023-05-07 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pk 11195 and Brain Ischemia
| Article | Year |
|---|---|
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
Global brain inflammation in stroke.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Encephalitis; Forecasting; Huma | 2019 |
24 other studies available for pk 11195 and Brain Ischemia
| Article | Year |
|---|---|
[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; CD11b Antigen; Disease Models, Animal; Fluorin | 2013 |
In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Brain Ischemia; Calcium-Bin | 2015 |
Changes of peripheral-type benzodiazepine receptors in the penumbra area after cerebral ischemia-reperfusion injury and effects of astragaloside IV on rats.
Topics: Animals; Brain; Brain Ischemia; Female; Isoquinolines; Male; Mitochondria; Rats, Sprague-Dawley; Rec | 2015 |
Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography.
Topics: Animals; Brain Ischemia; Cell Proliferation; Cerebral Arterial Diseases; Cerebral Infarction; Dideox | 2016 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline.
Topics: Animals; Binding, Competitive; Brain Ischemia; Carrageenan; Corpus Striatum; Disease Models, Animal; | 2004 |
Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Brain Mapping; Brain Stem; Carbon Radioisotopes; Cer | 2005 |
Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.
Topics: Acute Disease; Adult; Aged; Brain Ischemia; Carbon Radioisotopes; Female; Humans; Infarction, Middle | 2006 |
PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat.
Topics: Acetamides; Animals; Autoradiography; Brain Ischemia; Carbon Isotopes; Image Processing, Computer-As | 2007 |
Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury.
Topics: Animals; Autoradiography; Biomarkers; Brain Chemistry; Brain Injuries; Brain Ischemia; Carrier Prote | 2001 |
In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon.
Topics: Animals; Brain Ischemia; Brain Mapping; Cerebral Infarction; Flumazenil; Isoquinolines; Macrophages; | 1993 |
GM1 reduces infarct volume after focal cerebral ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Edema; Brain Ischemia; Caudate Nucleus; Cerebral Infa | 1994 |
Changes in [3H]-PK 11195 and [3H]-8-OH-DPAT binding following forebrain ischaemia in the gerbil.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Benzodiazepines; Benzodiazepinones | 1993 |
Evolution of dopamine receptors in the rat after neonatal hypoxia-ischemia: autoradiographic studies.
Topics: Animals; Animals, Newborn; Autoradiography; Brain Ischemia; Corpus Striatum; Hypoxia; Iodine Radiois | 1997 |
In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Ischemia; Carbon Radioisotopes; Cerebra | 2000 |
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Carbon Radioisotopes; Female; Humans; Isoquinolines; | 2000 |
Up-regulation of the peripheral-type benzodiazepine receptor expression and [(3)H]PK11195 binding in gerbil hippocampus after transient forebrain ischemia.
Topics: Animals; Antineoplastic Agents; Binding Sites; Brain Ischemia; Gene Expression Regulation; Gerbillin | 2001 |
Monitoring by PET of macrophage accumulation in brain after ischaemic stroke.
Topics: Brain Ischemia; Carbon Radioisotopes; Humans; Isoquinolines; Macrophages; Male; Middle Aged; Tomogra | 1992 |
Lack of neuroprotective effect of some sigma ligands in a model of focal cerebral ischemia in the mouse.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Dose-Response Relationship, Drug; Guanidines; Isoquinoline | 1992 |
The distribution of radioactivity in brains of rats given [N-methyl-11C]PK 11195 in vivo after induction of a cortical ischaemic lesion.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebral Cortex; Isoquinoline | 1992 |
[3H]PK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex.
Topics: Animals; Autoradiography; Brain Ischemia; Immunohistochemistry; Isoquinolines; Male; Motor Cortex; R | 1991 |
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.
Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Iso | 1990 |
Imaging of primary and remote ischaemic and excitotoxic brain lesions. An autoradiographic study of peripheral type benzodiazepine binding sites in the rat and cat.
Topics: Animals; Autoradiography; Benzazepines; Brain; Brain Ischemia; Cerebral Arteries; Dopamine Antagonis | 1988 |
Imaging of human brain lesions with an omega 3 site radioligand.
Topics: Adult; Aged; Autoradiography; Brain; Brain Ischemia; Brain Neoplasms; Glioblastoma; Humans; Isoquino | 1988 |