pk 11195 has been researched along with Brain Injuries in 14 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These results suggest that neither drug has therapeutic efficacy, however dosing and/or administration issues may have played a role." | 1.37 | Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury. ( Kelso, ML; Pauly, JR; Scheff, NN; Scheff, SW, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donat, CK | 1 |
| Fischer, F | 1 |
| Walter, B | 1 |
| Deuther-Conrad, W | 1 |
| Brodhun, M | 1 |
| Bauer, R | 1 |
| Brust, P | 1 |
| Toyama, H | 1 |
| Hatano, K | 1 |
| Suzuki, H | 1 |
| Ichise, M | 1 |
| Momosaki, S | 1 |
| Kudo, G | 1 |
| Ito, F | 1 |
| Kato, T | 1 |
| Yamaguchi, H | 1 |
| Katada, K | 1 |
| Sawada, M | 1 |
| Ito, K | 1 |
| Soustiel, JF | 1 |
| Zaaroor, M | 1 |
| Vlodavsky, E | 1 |
| Veenman, L | 1 |
| Weizman, A | 1 |
| Gavish, M | 1 |
| Kelso, ML | 1 |
| Scheff, NN | 1 |
| Scheff, SW | 1 |
| Pauly, JR | 3 |
| Folkersma, H | 2 |
| Foster Dingley, JC | 1 |
| van Berckel, BN | 2 |
| Rozemuller, A | 1 |
| Boellaard, R | 2 |
| Huisman, MC | 1 |
| Lammertsma, AA | 2 |
| Vandertop, WP | 2 |
| Molthoff, CF | 1 |
| Ramlackhansingh, AF | 1 |
| Brooks, DJ | 1 |
| Greenwood, RJ | 1 |
| Bose, SK | 1 |
| Turkheimer, FE | 1 |
| Kinnunen, KM | 1 |
| Gentleman, S | 1 |
| Heckemann, RA | 1 |
| Gunanayagam, K | 1 |
| Gelosa, G | 1 |
| Sharp, DJ | 1 |
| Yaqub, M | 1 |
| Kloet, RW | 1 |
| Windhorst, AD | 1 |
| van Bregt, DR | 1 |
| Thomas, TC | 2 |
| Hinzman, JM | 1 |
| Cao, T | 2 |
| Liu, M | 1 |
| Bing, G | 1 |
| Gerhardt, GA | 1 |
| Lifshitz, J | 2 |
| Ziebell, JM | 1 |
| Venneti, S | 1 |
| Wagner, AK | 1 |
| Wang, G | 1 |
| Slagel, SL | 1 |
| Chen, X | 1 |
| Lopresti, BJ | 1 |
| Mathis, CA | 1 |
| Wiley, CA | 1 |
| Benavides, J | 1 |
| Dubois, A | 1 |
| Scatton, B | 1 |
| Miyazawa, N | 1 |
| Diksic, M | 1 |
| Yamamoto, Y | 1 |
| Banati, RB | 1 |
| Myers, R | 1 |
| Kreutzberg, GW | 1 |
| Raghavendra Rao, VL | 1 |
| Dogan, A | 1 |
| Bowen, KK | 1 |
| Dempsey, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain Inflammation In Major Depressive Disorder[NCT01851356] | 61 participants (Actual) | Observational | 2013-05-08 | Completed | |||
| Assessment of [11C]ER-176 to Image Translocator Protein in Brain and Whole-Body of Healthy Subjects[NCT02147392] | Early Phase 1 | 16 participants (Actual) | Interventional | 2014-05-14 | Completed | ||
| Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy[NCT01793532] | 38 participants (Actual) | Observational | 2013-01-31 | Completed | |||
| PET Imaging of Peripheral Benzodiazepine Receptors Using [11C](R)-PK 11195 and [11C]PBR28[NCT00696371] | 15 participants (Actual) | Observational | 2008-06-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for pk 11195 and Brain Injuries
| Article | Year |
|---|---|
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Brain Injuries; Cannabinoid | 2014 |
In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum.
Topics: Animals; Brain Injuries; Carrier Proteins; Corpus Striatum; Disease Models, Animal; Ethanol; Isoquin | 2008 |
Neuroprotective effect of Ro5-4864 following brain injury.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodiazepinones; Brain Injuries; Carrier Proteins; Casp | 2008 |
Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Avoidance Learning; Brain Injuries; Cerebral Cortex; D | 2011 |
Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study.
Topics: Animals; Antineoplastic Agents; Brain; Brain Injuries; Carbon Radioisotopes; Fluorescent Dyes; Gluta | 2011 |
Inflammation after trauma: microglial activation and traumatic brain injury.
Topics: Adult; Amnesia; Brain Injuries; Cluster Analysis; Cognition Disorders; Diffusion Tensor Imaging; Edu | 2011 |
Widespread and prolonged increase in (R)-(11)C-PK11195 binding after traumatic brain injury.
Topics: Adolescent; Adult; Biomarkers; Brain Injuries; Carbon Radioisotopes; Case-Control Studies; Cluster A | 2011 |
Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atrophy; Brain Injuries; Calcium-Binding Proteins; Carrier | 2012 |
Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Calcium-Bind | 2012 |
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.
Topics: Acetamides; Animals; Autoradiography; Binding, Competitive; Brain; Brain Injuries; Cell Death; Glios | 2007 |
Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury.
Topics: Animals; Autoradiography; Biomarkers; Brain Chemistry; Brain Injuries; Brain Ischemia; Carrier Prote | 2001 |
Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis.
Topics: Animals; Autoradiography; Brain; Brain Injuries; Dominance, Cerebral; Female; Gliosis; Isoquinolines | 1995 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Injuries; Facial Nerve; Isoquinolines; M | 1997 |
Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus.
Topics: Animals; Antineoplastic Agents; Astrocytes; Autoradiography; Biomarkers; Brain Injuries; Cell Death; | 2000 |