pk 11195 has been researched along with Brain Edema in 4 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Besides, neuroinflammation has captured more attention in the process of HE, but the mechanism of neuroinflammation leading to HE remains unclear." | 2.52 | PET and MR imaging of neuroinflammation in hepatic encephalopathy. ( Lu, GM; Su, YY; Wu, S; Yang, GF; Zhang, LJ, 2015) |
| "Cerebral ischemia was induced by permanent occlusion of left middle cerebral artery." | 1.29 | GM1 reduces infarct volume after focal cerebral ischemia. ( Koga, T; Lazzaro, A; Manev, H; Schiavo, N; Seren, MS; Zanoni, R, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, YY | 1 |
| Yang, GF | 1 |
| Lu, GM | 1 |
| Wu, S | 1 |
| Zhang, LJ | 1 |
| Norenberg, MD | 2 |
| Bender, AS | 2 |
| Lazzaro, A | 1 |
| Seren, MS | 1 |
| Koga, T | 1 |
| Zanoni, R | 1 |
| Schiavo, N | 1 |
| Manev, H | 1 |
1 review available for pk 11195 and Brain Edema
| Article | Year |
|---|---|
PET and MR imaging of neuroinflammation in hepatic encephalopathy.
Topics: Amino Acid Transport System X-AG; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cytokines; Disea | 2015 |
3 other studies available for pk 11195 and Brain Edema
| Article | Year |
|---|---|
Astrocyte swelling in liver failure: role of glutamine and benzodiazepines.
Topics: Ammonia; Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cerebral Cortex; Chlor | 1994 |
GM1 reduces infarct volume after focal cerebral ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Edema; Brain Ischemia; Caudate Nucleus; Cerebral Infa | 1994 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cel | 1998 |