pk 11195 has been researched along with Body Weight in 9 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was undertaken to evaluate the effect of acute and repeated (daily and weekly) intravenous (IV) administration of PK 11 195 (PK; 10 mg kg(-1)) on body weight (BW) in Sprague-Dawley male and female rats exposed for 4-8 weeks to diazepam (DZ) slowly released from Silastic capsules (120 and 90 mg/capsule/week for males and females, respectively)." | 7.70 | The effect of PK 11 195, a specific antagonist of the peripheral benzodiazepine receptors, on body weight in rats chronically exposed to diazepam. ( Jing, X; Sloan, JW; Wala, EP, 2000) |
| "This study was undertaken to evaluate the effect of acute and repeated (daily and weekly) intravenous (IV) administration of PK 11 195 (PK; 10 mg kg(-1)) on body weight (BW) in Sprague-Dawley male and female rats exposed for 4-8 weeks to diazepam (DZ) slowly released from Silastic capsules (120 and 90 mg/capsule/week for males and females, respectively)." | 3.70 | The effect of PK 11 195, a specific antagonist of the peripheral benzodiazepine receptors, on body weight in rats chronically exposed to diazepam. ( Jing, X; Sloan, JW; Wala, EP, 2000) |
| "Body weight was quantified immediately before each injection, and 2 h after the last injection, while core temperature and locomotor activity were continuously monitored via radiotelemetry." | 1.35 | A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse. ( Ciullo, JR; De La Garza, R; Fantegrossi, WE; Traynor, JR; Wakabayashi, KT; Woods, JH, 2008) |
| "When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex." | 1.31 | The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. ( Holtman, JR; Jing, X; Sloan, JW; Wala, EP, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Escubedo, E | 2 |
| Chipana, C | 1 |
| Pérez-Sánchez, M | 1 |
| Camarasa, J | 2 |
| Pubill, D | 2 |
| Fantegrossi, WE | 1 |
| Ciullo, JR | 1 |
| Wakabayashi, KT | 1 |
| De La Garza, R | 1 |
| Traynor, JR | 1 |
| Woods, JH | 1 |
| Wong, PT | 1 |
| Tan, CH | 1 |
| Kwan, MF | 1 |
| Ang, LK | 1 |
| Teo, WL | 1 |
| Amiri, Z | 1 |
| Katz, Y | 1 |
| Weizman, A | 1 |
| Bidder, M | 1 |
| Snyder, SH | 1 |
| Gavish, M | 1 |
| Sloan, JW | 4 |
| Wala, E | 1 |
| Jing, X | 4 |
| Holtman, JR | 3 |
| Milliken, B | 1 |
| Wala, EP | 3 |
| Verdaguer, E | 1 |
| Canudas, AM | 1 |
| Sureda, FX | 1 |
| Pallàs, M | 1 |
| Camins, A | 1 |
9 other studies available for pk 11195 and Body Weight
| Article | Year |
|---|---|
Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antioxidants; Blotting, Western; Body T | 2005 |
A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Brain; Brain Chemistry; Central Nervous Sy | 2008 |
Effects of ethanol on peripheral benzodiazepine binding sites in the mouse cerebellum and brain stem.
Topics: Alcoholism; Animals; Benzodiazepines; Body Weight; Brain Stem; Cerebellum; Disease Models, Animal; D | 1995 |
Adrenal mitochondrial benzodiazepine receptors are sensitive to agents active at the dopamine receptor.
Topics: Adrenal Glands; Animals; Body Weight; Bromocriptine; Isoquinolines; Kidney; Male; Metoclopramide; Mi | 1993 |
Diazepam-treated female rats: flumazenil- and PK 11195-induced withdrawal in the hippocampus CA1.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dose-Response Relationship, Drug; Electroenceph | 1998 |
Precipitated withdrawal in the substantia nigra in diazepam-dependent female rats.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Electroencephalography; Female; Flumazenil; GAB | 1999 |
The effect of PK 11 195, a specific antagonist of the peripheral benzodiazepine receptors, on body weight in rats chronically exposed to diazepam.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Female; GABA-A Receptor Antagonists; Isoquinoli | 2000 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazeni | 2000 |
Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Body Weight; Cell Survival; Cerebellum; Corpus | 2001 |