pk 11195 has been researched along with Bipolar Disorder in 4 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The equilibrium binding parameters of the specific TSPO ligand [(3)H]PK 11195 were estimated on the platelet membranes of 24 adult outpatients with a DSM-IV diagnosis of bipolar disorder (with or without separation anxiety disorder) and 14 healthy controls." | 3.76 | Reductions in platelet 18-kDa translocator protein density are associated with adult separation anxiety in patients with bipolar disorder. ( Abelli, M; Cardini, A; Cassano, GB; Chelli, B; Costa, B; Gesi, C; Lari, L; Lucacchini, A; Martini, C; Muti, M; Pini, S, 2010) |
| "In combat-related PTSD, the 18 kDa mitochondrial translocator protein (TSPO), essential for steroid synthesis, was found to be decreased." | 1.36 | Lifetime manic-hypomanic symptoms in post-traumatic stress disorder: relationship with the 18 kDa mitochondrial translocator protein density. ( Carmassi, C; Ciapparelli, A; Da Pozzo, E; Dell'Osso, L; Martini, C; Trincavelli, ML, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haarman, BC | 2 |
| Riemersma-Van der Lek, RF | 2 |
| de Groot, JC | 2 |
| Ruhé, HG | 1 |
| Klein, HC | 1 |
| Zandstra, TE | 1 |
| Burger, H | 2 |
| Schoevers, RA | 1 |
| de Vries, EF | 2 |
| Drexhage, HA | 2 |
| Nolen, WA | 2 |
| Doorduin, J | 2 |
| Renken, RJ | 1 |
| Sibeijn-Kuiper, AJ | 1 |
| Marsman, JB | 1 |
| Mendes, R | 1 |
| Dell'Osso, L | 1 |
| Da Pozzo, E | 1 |
| Carmassi, C | 1 |
| Trincavelli, ML | 1 |
| Ciapparelli, A | 1 |
| Martini, C | 2 |
| Abelli, M | 1 |
| Chelli, B | 1 |
| Costa, B | 1 |
| Lari, L | 1 |
| Cardini, A | 1 |
| Gesi, C | 1 |
| Muti, M | 1 |
| Lucacchini, A | 1 |
| Cassano, GB | 1 |
| Pini, S | 1 |
4 other studies available for pk 11195 and Bipolar Disorder
| Article | Year |
|---|---|
Neuroinflammation in bipolar disorder - A [(11)C]-(R)-PK11195 positron emission tomography study.
Topics: Adult; Aged; Bipolar Disorder; Carbon Radioisotopes; Encephalitis; Female; Hippocampus; Humans; Isoq | 2014 |
Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study.
Topics: Adult; Aged; Bipolar Disorder; Carbon Radioisotopes; Female; Hippocampus; Humans; Inflammation; Isoq | 2016 |
Lifetime manic-hypomanic symptoms in post-traumatic stress disorder: relationship with the 18 kDa mitochondrial translocator protein density.
Topics: Adult; Antineoplastic Agents; Bipolar Disorder; Female; Humans; Isoquinolines; Life Change Events; L | 2010 |
Reductions in platelet 18-kDa translocator protein density are associated with adult separation anxiety in patients with bipolar disorder.
Topics: Adult; Anxiety, Separation; Bipolar Disorder; Blood Platelets; Female; Gene Expression Regulation; H | 2010 |