pk 11195 has been researched along with Aura in 8 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Brackhan, M | 1 |
| Bascuñana, P | 1 |
| Postema, JM | 1 |
| Ross, TL | 1 |
| Bengel, FM | 1 |
| Bankstahl, M | 1 |
| Bankstahl, JP | 1 |
| Butler, T | 1 |
| Ichise, M | 1 |
| Teich, AF | 1 |
| Gerard, E | 1 |
| Osborne, J | 1 |
| French, J | 1 |
| Devinsky, O | 1 |
| Kuzniecky, R | 1 |
| Gilliam, F | 1 |
| Pervez, F | 1 |
| Provenzano, F | 1 |
| Goldsmith, S | 1 |
| Vallabhajosula, S | 1 |
| Stern, E | 1 |
| Silbersweig, D | 1 |
| Kumar, A | 1 |
| Chugani, HT | 1 |
| Luat, A | 1 |
| Asano, E | 1 |
| Sood, S | 1 |
| Larkin, JG | 1 |
| McKee, PJ | 1 |
| Thompson, GG | 1 |
| Brodie, MJ | 1 |
| Nakamoto, Y | 1 |
| Watabe, S | 1 |
| Shiotani, T | 1 |
| Yoshii, M | 1 |
| Caldiroli, E | 1 |
| De Ponti, F | 1 |
| Cosentino, M | 1 |
| Marino, F | 1 |
| Fietta, AM | 1 |
| Taddei, M | 1 |
| Tartara, A | 1 |
| Zibetti, A | 1 |
| Mazzone, A | 1 |
| Lecchini, S | 1 |
| Frigo, GM | 1 |
| Weizman, A | 1 |
| Tanne, Z | 1 |
| Karp, L | 1 |
| Martfeld, Y | 1 |
| Tyano, S | 1 |
| Gavish, M | 1 |
8 other studies available for pk 11195 and Aura
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Serial Quantitative TSPO-Targeted PET Reveals Peak Microglial Activation up to 2 Weeks After an Epileptogenic Brain Insult.
Topics: Animals; Brain; Epilepsy; Female; Isoquinolines; Microglia; Pathology, Molecular; Positron-Emission | 2016 |
Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia.
Topics: Adult; Diagnosis, Differential; Encephalitis; Epilepsy; Female; Humans; Isoquinolines; Malformations | 2013 |
Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography.
Topics: Antineoplastic Agents; Brain; Child, Preschool; Drug Resistance; Encephalitis; Epilepsy; Hemianopsia | 2008 |
Peripheral benzodiazepine receptors in platelets of epileptic patients.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; B | 1993 |
Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding Sites; Cell Fractionation; Convulsants; Epi | 1996 |
Carbamazepine affects neutrophil function through an action on peripheral benzodiazepine receptors.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Carbamazepine; Cells, Cultured; Chemotaxis, Leukocyte; C | 1997 |
Carbamazepine up-regulates the binding of [3H]PK 11195 to platelets of epileptic patients.
Topics: Adolescent; Adult; Blood Platelets; Carbamazepine; Cell Membrane; Epilepsy; Female; Humans; Isoquino | 1987 |