pk 11195 has been researched along with Atrophy in 3 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Excerpt | Relevance | Reference |
---|---|---|
"By contrast, patients with Alzheimer's disease showed significantly increased regional [11C](R)-PK11195 binding in the entorhinal, temporoparietal, and cingulate cortex." | 1.31 | In-vivo measurement of activated microglia in dementia. ( Banati, RB; Brooks, DJ; Cagnin, A; Gunn, RN; Jones, T; Kennedy, AM; Myers, R; Turkheimer, FE, 2001) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (66.67) | 29.6817 |
2010's | 1 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
van Bregt, DR | 1 |
Thomas, TC | 1 |
Hinzman, JM | 1 |
Cao, T | 1 |
Liu, M | 1 |
Bing, G | 1 |
Gerhardt, GA | 1 |
Pauly, JR | 1 |
Lifshitz, J | 1 |
Versijpt, J | 1 |
Debruyne, JC | 1 |
Van Laere, KJ | 1 |
De Vos, F | 1 |
Keppens, J | 1 |
Strijckmans, K | 1 |
Achten, E | 1 |
Slegers, G | 1 |
Dierckx, RA | 1 |
Korf, J | 1 |
De Reuck, JL | 1 |
Cagnin, A | 1 |
Brooks, DJ | 1 |
Kennedy, AM | 1 |
Gunn, RN | 1 |
Myers, R | 1 |
Turkheimer, FE | 1 |
Jones, T | 1 |
Banati, RB | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Brain Inflammation In Major Depressive Disorder[NCT01851356] | 61 participants (Actual) | Observational | 2013-05-08 | Completed | |||
Assessment of [11C]ER-176 to Image Translocator Protein in Brain and Whole-Body of Healthy Subjects[NCT02147392] | Early Phase 1 | 16 participants (Actual) | Interventional | 2014-05-14 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 trial available for pk 11195 and Atrophy
Article | Year |
---|---|
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study.
Topics: Adult; Aged; Antineoplastic Agents; Atrophy; Brain; Carbon Radioisotopes; Female; Humans; Isoquinoli | 2005 |
2 other studies available for pk 11195 and Atrophy
Article | Year |
---|---|
Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atrophy; Brain Injuries; Calcium-Binding Proteins; Carrier | 2012 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |