Page last updated: 2024-10-21

pk 11195 and Atrophy

pk 11195 has been researched along with Atrophy in 3 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research Excerpts

ExcerptRelevanceReference
"By contrast, patients with Alzheimer's disease showed significantly increased regional [11C](R)-PK11195 binding in the entorhinal, temporoparietal, and cingulate cortex."1.31In-vivo measurement of activated microglia in dementia. ( Banati, RB; Brooks, DJ; Cagnin, A; Gunn, RN; Jones, T; Kennedy, AM; Myers, R; Turkheimer, FE, 2001)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
van Bregt, DR1
Thomas, TC1
Hinzman, JM1
Cao, T1
Liu, M1
Bing, G1
Gerhardt, GA1
Pauly, JR1
Lifshitz, J1
Versijpt, J1
Debruyne, JC1
Van Laere, KJ1
De Vos, F1
Keppens, J1
Strijckmans, K1
Achten, E1
Slegers, G1
Dierckx, RA1
Korf, J1
De Reuck, JL1
Cagnin, A1
Brooks, DJ1
Kennedy, AM1
Gunn, RN1
Myers, R1
Turkheimer, FE1
Jones, T1
Banati, RB1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Brain Inflammation In Major Depressive Disorder[NCT01851356]61 participants (Actual)Observational2013-05-08Completed
Assessment of [11C]ER-176 to Image Translocator Protein in Brain and Whole-Body of Healthy Subjects[NCT02147392]Early Phase 116 participants (Actual)Interventional2014-05-14Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for pk 11195 and Atrophy

ArticleYear
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2005, Volume: 11, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Atrophy; Brain; Carbon Radioisotopes; Female; Humans; Isoquinoli

2005

Other Studies

2 other studies available for pk 11195 and Atrophy

ArticleYear
Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.
    Experimental neurology, 2012, Volume: 234, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atrophy; Brain Injuries; Calcium-Binding Proteins; Carrier

2012
In-vivo measurement of activated microglia in dementia.
    Lancet (London, England), 2001, Aug-11, Volume: 358, Issue:9280

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro

2001
In-vivo measurement of activated microglia in dementia.
    Lancet (London, England), 2001, Aug-11, Volume: 358, Issue:9280

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro

2001
In-vivo measurement of activated microglia in dementia.
    Lancet (London, England), 2001, Aug-11, Volume: 358, Issue:9280

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro

2001
In-vivo measurement of activated microglia in dementia.
    Lancet (London, England), 2001, Aug-11, Volume: 358, Issue:9280

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro

2001