pk 11195 and Atrophy
pk 11195 has been researched along with Atrophy in 3 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "By contrast, patients with Alzheimer's disease showed significantly increased regional [11C](R)-PK11195 binding in the entorhinal, temporoparietal, and cingulate cortex." | 1.31 | In-vivo measurement of activated microglia in dementia. ( Banati, RB; Brooks, DJ; Cagnin, A; Gunn, RN; Jones, T; Kennedy, AM; Myers, R; Turkheimer, FE, 2001) |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| van Bregt, DR | 1 |
| Thomas, TC | 1 |
| Hinzman, JM | 1 |
| Cao, T | 1 |
| Liu, M | 1 |
| Bing, G | 1 |
| Gerhardt, GA | 1 |
| Pauly, JR | 1 |
| Lifshitz, J | 1 |
| Versijpt, J | 1 |
| Debruyne, JC | 1 |
| Van Laere, KJ | 1 |
| De Vos, F | 1 |
| Keppens, J | 1 |
| Strijckmans, K | 1 |
| Achten, E | 1 |
| Slegers, G | 1 |
| Dierckx, RA | 1 |
| Korf, J | 1 |
| De Reuck, JL | 1 |
| Cagnin, A | 1 |
| Brooks, DJ | 1 |
| Kennedy, AM | 1 |
| Gunn, RN | 1 |
| Myers, R | 1 |
| Turkheimer, FE | 1 |
| Jones, T | 1 |
| Banati, RB | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain Inflammation In Major Depressive Disorder[NCT01851356] | 61 participants (Actual) | Observational | 2013-05-08 | Completed | |||
| Assessment of [11C]ER-176 to Image Translocator Protein in Brain and Whole-Body of Healthy Subjects[NCT02147392] | Early Phase 1 | 16 participants (Actual) | Interventional | 2014-05-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
1 trial available for pk 11195 and Atrophy
| Article | Year |
|---|---|
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study.
Topics: Adult; Aged; Antineoplastic Agents; Atrophy; Brain; Carbon Radioisotopes; Female; Humans; Isoquinoli | 2005 |
Other Studies
2 other studies available for pk 11195 and Atrophy
| Article | Year |
|---|---|
Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atrophy; Brain Injuries; Calcium-Binding Proteins; Carrier | 2012 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |
In-vivo measurement of activated microglia in dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Carbon Radioisotopes; Case-Contro | 2001 |