pk 11195 has been researched along with Astrocytosis in 24 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Excerpt | Relevance | Reference |
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"Striatal gliosis induced by 3-NP treatment was prevented by (+/-)-huprine Y pretreatment, as demonstrated by the attenuation of both the increase in [(3)H]PK 11195 specific binding indicative of microgliosis and the expression of hsp27 kDa, a chaperone expressed mainly in astrocytes." | 1.32 | Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage. ( Camins, A; Camps, P; Canudas, AM; Jiménez, A; Muñoz-Torrero, D; Pallàs, M; Pubill, D; Sureda, FX; Verdaguer, E, 2003) |
"We characterized the gliosis associated with the IDPN-induced retinal degeneration in comparison to other effects on the visual and central nervous systems." | 1.30 | Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure. ( Ambrosio, S; Espejo, M; Llorens, J; Pallàs, M; Rodríguez-Farré, E; Seoane, A, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 4 (16.67) | 18.2507 |
2000's | 19 (79.17) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (4.17) | 2.80 |
Authors | Studies |
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Ni, R | 1 |
Röjdner, J | 1 |
Voytenko, L | 1 |
Dyrks, T | 1 |
Thiele, A | 1 |
Marutle, A | 1 |
Nordberg, A | 1 |
Wiley, CA | 3 |
Lopresti, BJ | 4 |
Venneti, S | 3 |
Price, J | 1 |
Klunk, WE | 1 |
DeKosky, ST | 1 |
Mathis, CA | 3 |
Visigalli, I | 1 |
Moresco, RM | 1 |
Belloli, S | 1 |
Politi, LS | 1 |
Gritti, A | 1 |
Ungaro, D | 1 |
Matarrese, M | 1 |
Turolla, E | 1 |
Falini, A | 1 |
Scotti, G | 1 |
Naldini, L | 1 |
Fazio, F | 1 |
Biffi, A | 1 |
Mason, NS | 2 |
Weissman, BA | 1 |
Raveh, L | 1 |
Mankowski, JL | 1 |
Queen, SE | 1 |
Tarwater, PJ | 1 |
Adams, RJ | 1 |
Guilarte, TR | 1 |
Canudas, AM | 1 |
Pubill, D | 1 |
Sureda, FX | 1 |
Verdaguer, E | 1 |
Camps, P | 1 |
Muñoz-Torrero, D | 1 |
Jiménez, A | 1 |
Camins, A | 1 |
Pallàs, M | 2 |
Wilms, H | 1 |
Claasen, J | 1 |
Röhl, C | 1 |
Sievers, J | 1 |
Deuschl, G | 1 |
Lucius, R | 1 |
Roulston, CL | 1 |
Lawrence, AJ | 1 |
Jarrott, B | 1 |
Widdop, RE | 1 |
Veiga, S | 2 |
Azcoitia, I | 2 |
Garcia-Segura, LM | 2 |
Banati, RB | 1 |
Egensperger, R | 1 |
Maassen, A | 1 |
Hager, G | 1 |
Kreutzberg, GW | 1 |
Graeber, MB | 1 |
Ryu, JK | 1 |
Choi, HB | 1 |
McLarnon, JG | 1 |
Maeda, J | 1 |
Higuchi, M | 2 |
Suhara, T | 2 |
Wang, G | 2 |
Slagel, SL | 2 |
Fischer, ML | 1 |
Larsen, NJ | 1 |
Mortimer, AD | 1 |
Hastings, TG | 1 |
Smith, AD | 1 |
Zigmond, MJ | 1 |
Wagner, AK | 1 |
Chen, X | 1 |
Carrero, P | 1 |
Pernia, O | 1 |
Boutin, H | 1 |
Chauveau, F | 1 |
Thominiaux, C | 1 |
Kuhnast, B | 1 |
Grégoire, MC | 1 |
Jan, S | 1 |
Trebossen, R | 1 |
Dollé, F | 1 |
Tavitian, B | 1 |
Mattner, F | 1 |
Katsifis, A | 1 |
Vas, A | 1 |
Shchukin, Y | 1 |
Karrenbauer, VD | 1 |
Cselényi, Z | 1 |
Kostulas, K | 1 |
Hillert, J | 1 |
Savic, I | 1 |
Takano, A | 1 |
Halldin, C | 1 |
Gulyás, B | 1 |
Miyazawa, N | 1 |
Diksic, M | 1 |
Yamamoto, Y | 1 |
MacGregor, DG | 1 |
Graham, DI | 1 |
Stone, TW | 1 |
Seoane, A | 1 |
Espejo, M | 1 |
Rodríguez-Farré, E | 1 |
Ambrosio, S | 1 |
Llorens, J | 1 |
Sitte, HH | 1 |
Wanschitz, J | 1 |
Budka, H | 1 |
Berger, ML | 1 |
Cicchetti, F | 1 |
Brownell, AL | 1 |
Williams, K | 1 |
Chen, YI | 1 |
Livni, E | 1 |
Isacson, O | 1 |
Altar, CA | 1 |
Baudry, M | 1 |
2 reviews available for pk 11195 and Astrocytosis
Article | Year |
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Peripheral benzodiazepine receptors: on mice and human brain imaging.
Topics: Animals; Autoradiography; Benzodiazepinones; Brain; Carbon Radioisotopes; Gliosis; Humans; Isoquinol | 2003 |
[Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands].
Topics: Acetamides; Animals; Biomarkers; Carbon Radioisotopes; Gliosis; Humans; Isoquinolines; Ligands; Neur | 2006 |
1 trial available for pk 11195 and Astrocytosis
Article | Year |
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Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Binding, Competitive; Biomarkers; Brain Mapping; Carb | 2008 |
21 other studies available for pk 11195 and Astrocytosis
Article | Year |
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In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer's Brain Tissue.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Brain | 2021 |
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antineoplastic | 2009 |
Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195.
Topics: Animals; Brain; Carbon Radioisotopes; Central Nervous System Diseases; Demyelinating Diseases; Disea | 2009 |
2-18F-fluoroacetate: a useful tool for assessing gliosis in the central nervous system?
Topics: Blood-Brain Barrier; Brain; Fluorine Radioisotopes; Fluoroacetates; Gliosis; Humans; Isoquinolines; | 2009 |
Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis.
Topics: Animals; Antineoplastic Agents; Encephalitis, Viral; Gliosis; Isoquinolines; Macaca nemestrina; Macr | 2003 |
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Co | 2003 |
Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro.
Topics: Animals; Animals, Newborn; Benzodiazepines; Binding Sites; Cell Division; Cells, Cultured; Encephali | 2003 |
Non-angiotensin II [(125)I] CGP42112 binding is a sensitive marker of neuronal injury in brainstem following unilateral nodose ganglionectomy: comparison with markers for activated microglia.
Topics: Angiotensin II; Animals; Autoradiography; Biomarkers; Brain Stem; Ganglionectomy; Glial Fibrillary A | 2004 |
Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity.
Topics: Animals; Benzodiazepinones; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemist | 2005 |
Mitochondria in activated microglia in vitro.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Binding Sites; Carbocyanines; Carrier Proteins; Cell | 2004 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.
Topics: Acetamides; Animals; Binding, Competitive; Brain; Disease Models, Animal; Encephalitis; Gliosis; Iso | 2007 |
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.
Topics: Acetamides; Animals; Autoradiography; Binding, Competitive; Brain; Brain Injuries; Cell Death; Glios | 2007 |
Translocator protein 18 kDa is involved in the regulation of reactive gliosis.
Topics: Animals; Antineoplastic Agents; Astrocytes; Benzodiazepinones; Biomarkers; Cell Death; Cell Prolifer | 2007 |
In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.
Topics: Acetamides; Animals; Antineoplastic Agents; Binding, Competitive; Brain; Carbon Radioisotopes; Disea | 2007 |
Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis.
Topics: Animals; Autoradiography; Brain; Brain Injuries; Dominance, Cerebral; Female; Gliosis; Isoquinolines | 1995 |
The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists.
Topics: Adenosine; Animals; Body Temperature; Chlormethiazole; Dizocilpine Maleate; Drug Synergism; Drug The | 1997 |
Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure.
Topics: Animals; Antineoplastic Agents; Auditory Cortex; Benzamides; Cerebral Cortex; Glial Fibrillary Acidi | 1999 |
Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antineoplastic Agents; Autoradiography; Binding Sites; B | 2001 |
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins; | 2002 |
Systemic injection of kainic acid: gliosis in olfactory and limbic brain regions quantified with [3H]PK 11195 binding autoradiography.
Topics: Animals; Autoradiography; Binding, Competitive; Gliosis; Injections, Intraperitoneal; Isoquinolines; | 1990 |