Page last updated: 2024-10-21

pk 11195 and Astrocytosis

pk 11195 has been researched along with Astrocytosis in 24 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Research Excerpts

ExcerptRelevanceReference
"Striatal gliosis induced by 3-NP treatment was prevented by (+/-)-huprine Y pretreatment, as demonstrated by the attenuation of both the increase in [(3)H]PK 11195 specific binding indicative of microgliosis and the expression of hsp27 kDa, a chaperone expressed mainly in astrocytes."1.32Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage. ( Camins, A; Camps, P; Canudas, AM; Jiménez, A; Muñoz-Torrero, D; Pallàs, M; Pubill, D; Sureda, FX; Verdaguer, E, 2003)
"We characterized the gliosis associated with the IDPN-induced retinal degeneration in comparison to other effects on the visual and central nervous systems."1.30Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure. ( Ambrosio, S; Espejo, M; Llorens, J; Pallàs, M; Rodríguez-Farré, E; Seoane, A, 1999)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (16.67)18.2507
2000's19 (79.17)29.6817
2010's0 (0.00)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Ni, R1
Röjdner, J1
Voytenko, L1
Dyrks, T1
Thiele, A1
Marutle, A1
Nordberg, A1
Wiley, CA3
Lopresti, BJ4
Venneti, S3
Price, J1
Klunk, WE1
DeKosky, ST1
Mathis, CA3
Visigalli, I1
Moresco, RM1
Belloli, S1
Politi, LS1
Gritti, A1
Ungaro, D1
Matarrese, M1
Turolla, E1
Falini, A1
Scotti, G1
Naldini, L1
Fazio, F1
Biffi, A1
Mason, NS2
Weissman, BA1
Raveh, L1
Mankowski, JL1
Queen, SE1
Tarwater, PJ1
Adams, RJ1
Guilarte, TR1
Canudas, AM1
Pubill, D1
Sureda, FX1
Verdaguer, E1
Camps, P1
Muñoz-Torrero, D1
Jiménez, A1
Camins, A1
Pallàs, M2
Wilms, H1
Claasen, J1
Röhl, C1
Sievers, J1
Deuschl, G1
Lucius, R1
Roulston, CL1
Lawrence, AJ1
Jarrott, B1
Widdop, RE1
Veiga, S2
Azcoitia, I2
Garcia-Segura, LM2
Banati, RB1
Egensperger, R1
Maassen, A1
Hager, G1
Kreutzberg, GW1
Graeber, MB1
Ryu, JK1
Choi, HB1
McLarnon, JG1
Maeda, J1
Higuchi, M2
Suhara, T2
Wang, G2
Slagel, SL2
Fischer, ML1
Larsen, NJ1
Mortimer, AD1
Hastings, TG1
Smith, AD1
Zigmond, MJ1
Wagner, AK1
Chen, X1
Carrero, P1
Pernia, O1
Boutin, H1
Chauveau, F1
Thominiaux, C1
Kuhnast, B1
Grégoire, MC1
Jan, S1
Trebossen, R1
Dollé, F1
Tavitian, B1
Mattner, F1
Katsifis, A1
Vas, A1
Shchukin, Y1
Karrenbauer, VD1
Cselényi, Z1
Kostulas, K1
Hillert, J1
Savic, I1
Takano, A1
Halldin, C1
Gulyás, B1
Miyazawa, N1
Diksic, M1
Yamamoto, Y1
MacGregor, DG1
Graham, DI1
Stone, TW1
Seoane, A1
Espejo, M1
Rodríguez-Farré, E1
Ambrosio, S1
Llorens, J1
Sitte, HH1
Wanschitz, J1
Budka, H1
Berger, ML1
Cicchetti, F1
Brownell, AL1
Williams, K1
Chen, YI1
Livni, E1
Isacson, O1
Altar, CA1
Baudry, M1

Reviews

2 reviews available for pk 11195 and Astrocytosis

ArticleYear
Peripheral benzodiazepine receptors: on mice and human brain imaging.
    Journal of neurochemistry, 2003, Volume: 84, Issue:3

    Topics: Animals; Autoradiography; Benzodiazepinones; Brain; Carbon Radioisotopes; Gliosis; Humans; Isoquinol

2003
[Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2006, Volume: 26, Issue:1

    Topics: Acetamides; Animals; Biomarkers; Carbon Radioisotopes; Gliosis; Humans; Isoquinolines; Ligands; Neur

2006

Trials

1 trial available for pk 11195 and Astrocytosis

ArticleYear
Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.
    Journal of the neurological sciences, 2008, Jan-15, Volume: 264, Issue:1-2

    Topics: Adult; Anticonvulsants; Antineoplastic Agents; Binding, Competitive; Biomarkers; Brain Mapping; Carb

2008

Other Studies

21 other studies available for pk 11195 and Astrocytosis

ArticleYear
In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer's Brain Tissue.
    Journal of Alzheimer's disease : JAD, 2021, Volume: 80, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Brain

2021
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
    Archives of neurology, 2009, Volume: 66, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antineoplastic

2009
Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195.
    Neurobiology of disease, 2009, Volume: 34, Issue:1

    Topics: Animals; Brain; Carbon Radioisotopes; Central Nervous System Diseases; Demyelinating Diseases; Disea

2009
2-18F-fluoroacetate: a useful tool for assessing gliosis in the central nervous system?
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:6

    Topics: Blood-Brain Barrier; Brain; Fluorine Radioisotopes; Fluoroacetates; Gliosis; Humans; Isoquinolines;

2009
Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis.
    Journal of neurovirology, 2003, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Agents; Encephalitis, Viral; Gliosis; Isoquinolines; Macaca nemestrina; Macr

2003
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
    Experimental neurology, 2003, Volume: 180, Issue:2

    Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Co

2003
Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro.
    Neurobiology of disease, 2003, Volume: 14, Issue:3

    Topics: Animals; Animals, Newborn; Benzodiazepines; Binding Sites; Cell Division; Cells, Cultured; Encephali

2003
Non-angiotensin II [(125)I] CGP42112 binding is a sensitive marker of neuronal injury in brainstem following unilateral nodose ganglionectomy: comparison with markers for activated microglia.
    Neuroscience, 2004, Volume: 127, Issue:3

    Topics: Angiotensin II; Animals; Autoradiography; Biomarkers; Brain Stem; Ganglionectomy; Glial Fibrillary A

2004
Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity.
    Journal of neuroscience research, 2005, Apr-01, Volume: 80, Issue:1

    Topics: Animals; Benzodiazepinones; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemist

2005
Mitochondria in activated microglia in vitro.
    Journal of neurocytology, 2004, Volume: 33, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzimidazoles; Binding Sites; Carbocyanines; Carrier Proteins; Cell

2004
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
    Neurobiology of disease, 2005, Volume: 20, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases;

2005
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.
    Journal of neurochemistry, 2007, Volume: 102, Issue:6

    Topics: Acetamides; Animals; Binding, Competitive; Brain; Disease Models, Animal; Encephalitis; Gliosis; Iso

2007
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.
    Experimental neurology, 2007, Volume: 207, Issue:1

    Topics: Acetamides; Animals; Autoradiography; Binding, Competitive; Brain; Brain Injuries; Cell Death; Glios

2007
Translocator protein 18 kDa is involved in the regulation of reactive gliosis.
    Glia, 2007, Nov-01, Volume: 55, Issue:14

    Topics: Animals; Antineoplastic Agents; Astrocytes; Benzodiazepinones; Biomarkers; Cell Death; Cell Prolifer

2007
In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.
    Glia, 2007, Nov-01, Volume: 55, Issue:14

    Topics: Acetamides; Animals; Antineoplastic Agents; Binding, Competitive; Brain; Carbon Radioisotopes; Disea

2007
Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis.
    Acta neurochirurgica, 1995, Volume: 137, Issue:3-4

    Topics: Animals; Autoradiography; Brain; Brain Injuries; Dominance, Cerebral; Female; Gliosis; Isoquinolines

1995
The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists.
    Experimental neurology, 1997, Volume: 148, Issue:1

    Topics: Adenosine; Animals; Body Temperature; Chlormethiazole; Dizocilpine Maleate; Drug Synergism; Drug The

1997
Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure.
    Brain research, 1999, Jul-03, Volume: 833, Issue:2

    Topics: Animals; Antineoplastic Agents; Auditory Cortex; Benzamides; Cerebral Cortex; Glial Fibrillary Acidi

1999
Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis.
    Acta neuropathologica, 2001, Volume: 101, Issue:2

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antineoplastic Agents; Autoradiography; Binding Sites; B

2001
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
    The European journal of neuroscience, 2002, Volume: 15, Issue:6

    Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins;

2002
Systemic injection of kainic acid: gliosis in olfactory and limbic brain regions quantified with [3H]PK 11195 binding autoradiography.
    Experimental neurology, 1990, Volume: 109, Issue:3

    Topics: Animals; Autoradiography; Binding, Competitive; Gliosis; Injections, Intraperitoneal; Isoquinolines;

1990