pk 11195 has been researched along with Astrocytosis in 24 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Striatal gliosis induced by 3-NP treatment was prevented by (+/-)-huprine Y pretreatment, as demonstrated by the attenuation of both the increase in [(3)H]PK 11195 specific binding indicative of microgliosis and the expression of hsp27 kDa, a chaperone expressed mainly in astrocytes." | 1.32 | Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage. ( Camins, A; Camps, P; Canudas, AM; Jiménez, A; Muñoz-Torrero, D; Pallàs, M; Pubill, D; Sureda, FX; Verdaguer, E, 2003) |
| "We characterized the gliosis associated with the IDPN-induced retinal degeneration in comparison to other effects on the visual and central nervous systems." | 1.30 | Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure. ( Ambrosio, S; Espejo, M; Llorens, J; Pallàs, M; Rodríguez-Farré, E; Seoane, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 19 (79.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Ni, R | 1 |
| Röjdner, J | 1 |
| Voytenko, L | 1 |
| Dyrks, T | 1 |
| Thiele, A | 1 |
| Marutle, A | 1 |
| Nordberg, A | 1 |
| Wiley, CA | 3 |
| Lopresti, BJ | 4 |
| Venneti, S | 3 |
| Price, J | 1 |
| Klunk, WE | 1 |
| DeKosky, ST | 1 |
| Mathis, CA | 3 |
| Visigalli, I | 1 |
| Moresco, RM | 1 |
| Belloli, S | 1 |
| Politi, LS | 1 |
| Gritti, A | 1 |
| Ungaro, D | 1 |
| Matarrese, M | 1 |
| Turolla, E | 1 |
| Falini, A | 1 |
| Scotti, G | 1 |
| Naldini, L | 1 |
| Fazio, F | 1 |
| Biffi, A | 1 |
| Mason, NS | 2 |
| Weissman, BA | 1 |
| Raveh, L | 1 |
| Mankowski, JL | 1 |
| Queen, SE | 1 |
| Tarwater, PJ | 1 |
| Adams, RJ | 1 |
| Guilarte, TR | 1 |
| Canudas, AM | 1 |
| Pubill, D | 1 |
| Sureda, FX | 1 |
| Verdaguer, E | 1 |
| Camps, P | 1 |
| Muñoz-Torrero, D | 1 |
| Jiménez, A | 1 |
| Camins, A | 1 |
| Pallàs, M | 2 |
| Wilms, H | 1 |
| Claasen, J | 1 |
| Röhl, C | 1 |
| Sievers, J | 1 |
| Deuschl, G | 1 |
| Lucius, R | 1 |
| Roulston, CL | 1 |
| Lawrence, AJ | 1 |
| Jarrott, B | 1 |
| Widdop, RE | 1 |
| Veiga, S | 2 |
| Azcoitia, I | 2 |
| Garcia-Segura, LM | 2 |
| Banati, RB | 1 |
| Egensperger, R | 1 |
| Maassen, A | 1 |
| Hager, G | 1 |
| Kreutzberg, GW | 1 |
| Graeber, MB | 1 |
| Ryu, JK | 1 |
| Choi, HB | 1 |
| McLarnon, JG | 1 |
| Maeda, J | 1 |
| Higuchi, M | 2 |
| Suhara, T | 2 |
| Wang, G | 2 |
| Slagel, SL | 2 |
| Fischer, ML | 1 |
| Larsen, NJ | 1 |
| Mortimer, AD | 1 |
| Hastings, TG | 1 |
| Smith, AD | 1 |
| Zigmond, MJ | 1 |
| Wagner, AK | 1 |
| Chen, X | 1 |
| Carrero, P | 1 |
| Pernia, O | 1 |
| Boutin, H | 1 |
| Chauveau, F | 1 |
| Thominiaux, C | 1 |
| Kuhnast, B | 1 |
| Grégoire, MC | 1 |
| Jan, S | 1 |
| Trebossen, R | 1 |
| Dollé, F | 1 |
| Tavitian, B | 1 |
| Mattner, F | 1 |
| Katsifis, A | 1 |
| Vas, A | 1 |
| Shchukin, Y | 1 |
| Karrenbauer, VD | 1 |
| Cselényi, Z | 1 |
| Kostulas, K | 1 |
| Hillert, J | 1 |
| Savic, I | 1 |
| Takano, A | 1 |
| Halldin, C | 1 |
| Gulyás, B | 1 |
| Miyazawa, N | 1 |
| Diksic, M | 1 |
| Yamamoto, Y | 1 |
| MacGregor, DG | 1 |
| Graham, DI | 1 |
| Stone, TW | 1 |
| Seoane, A | 1 |
| Espejo, M | 1 |
| Rodríguez-Farré, E | 1 |
| Ambrosio, S | 1 |
| Llorens, J | 1 |
| Sitte, HH | 1 |
| Wanschitz, J | 1 |
| Budka, H | 1 |
| Berger, ML | 1 |
| Cicchetti, F | 1 |
| Brownell, AL | 1 |
| Williams, K | 1 |
| Chen, YI | 1 |
| Livni, E | 1 |
| Isacson, O | 1 |
| Altar, CA | 1 |
| Baudry, M | 1 |
2 reviews available for pk 11195 and Astrocytosis
| Article | Year |
|---|---|
Peripheral benzodiazepine receptors: on mice and human brain imaging.
Topics: Animals; Autoradiography; Benzodiazepinones; Brain; Carbon Radioisotopes; Gliosis; Humans; Isoquinol | 2003 |
[Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands].
Topics: Acetamides; Animals; Biomarkers; Carbon Radioisotopes; Gliosis; Humans; Isoquinolines; Ligands; Neur | 2006 |
1 trial available for pk 11195 and Astrocytosis
| Article | Year |
|---|---|
Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Binding, Competitive; Biomarkers; Brain Mapping; Carb | 2008 |
21 other studies available for pk 11195 and Astrocytosis
| Article | Year |
|---|---|
In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer's Brain Tissue.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Brain | 2021 |
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antineoplastic | 2009 |
Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195.
Topics: Animals; Brain; Carbon Radioisotopes; Central Nervous System Diseases; Demyelinating Diseases; Disea | 2009 |
2-18F-fluoroacetate: a useful tool for assessing gliosis in the central nervous system?
Topics: Blood-Brain Barrier; Brain; Fluorine Radioisotopes; Fluoroacetates; Gliosis; Humans; Isoquinolines; | 2009 |
Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis.
Topics: Animals; Antineoplastic Agents; Encephalitis, Viral; Gliosis; Isoquinolines; Macaca nemestrina; Macr | 2003 |
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Co | 2003 |
Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro.
Topics: Animals; Animals, Newborn; Benzodiazepines; Binding Sites; Cell Division; Cells, Cultured; Encephali | 2003 |
Non-angiotensin II [(125)I] CGP42112 binding is a sensitive marker of neuronal injury in brainstem following unilateral nodose ganglionectomy: comparison with markers for activated microglia.
Topics: Angiotensin II; Animals; Autoradiography; Biomarkers; Brain Stem; Ganglionectomy; Glial Fibrillary A | 2004 |
Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity.
Topics: Animals; Benzodiazepinones; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemist | 2005 |
Mitochondria in activated microglia in vitro.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Binding Sites; Carbocyanines; Carrier Proteins; Cell | 2004 |
Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antineoplastic Agents; Carrier Proteins; Caspases; | 2005 |
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.
Topics: Acetamides; Animals; Binding, Competitive; Brain; Disease Models, Animal; Encephalitis; Gliosis; Iso | 2007 |
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.
Topics: Acetamides; Animals; Autoradiography; Binding, Competitive; Brain; Brain Injuries; Cell Death; Glios | 2007 |
Translocator protein 18 kDa is involved in the regulation of reactive gliosis.
Topics: Animals; Antineoplastic Agents; Astrocytes; Benzodiazepinones; Biomarkers; Cell Death; Cell Prolifer | 2007 |
In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.
Topics: Acetamides; Animals; Antineoplastic Agents; Binding, Competitive; Brain; Carbon Radioisotopes; Disea | 2007 |
Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis.
Topics: Animals; Autoradiography; Brain; Brain Injuries; Dominance, Cerebral; Female; Gliosis; Isoquinolines | 1995 |
The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists.
Topics: Adenosine; Animals; Body Temperature; Chlormethiazole; Dizocilpine Maleate; Drug Synergism; Drug The | 1997 |
Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure.
Topics: Animals; Antineoplastic Agents; Auditory Cortex; Benzamides; Cerebral Cortex; Glial Fibrillary Acidi | 1999 |
Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antineoplastic Agents; Autoradiography; Binding Sites; B | 2001 |
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins; | 2002 |
Systemic injection of kainic acid: gliosis in olfactory and limbic brain regions quantified with [3H]PK 11195 binding autoradiography.
Topics: Animals; Autoradiography; Binding, Competitive; Gliosis; Injections, Intraperitoneal; Isoquinolines; | 1990 |