pk 11195 has been researched along with Astrocytoma in 7 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| " With the aim to evidence if the TSPO expression level alters glioma cell susceptibility to undergo to cell death, we analysed the effects of the specific TSPO ligand, PK 11195, in human astrocytoma wild-type and TSPO-silenced cell lines." | 7.74 | PK 11195 differentially affects cell survival in human wild-type and 18 kDa translocator protein-silenced ADF astrocytoma cells. ( Chelli, B; Costa, B; Da Pozzo, E; Gremigni, V; Lena, A; Martini, C; Rainaldi, G; Rechichi, M; Rossi, L; Salvetti, A; Scatena, F; Spinetti, F; Vanacore, R, 2008) |
| " With the aim to evidence if the TSPO expression level alters glioma cell susceptibility to undergo to cell death, we analysed the effects of the specific TSPO ligand, PK 11195, in human astrocytoma wild-type and TSPO-silenced cell lines." | 3.74 | PK 11195 differentially affects cell survival in human wild-type and 18 kDa translocator protein-silenced ADF astrocytoma cells. ( Chelli, B; Costa, B; Da Pozzo, E; Gremigni, V; Lena, A; Martini, C; Rainaldi, G; Rechichi, M; Rossi, L; Salvetti, A; Scatena, F; Spinetti, F; Vanacore, R, 2008) |
| "TSPO in gliomas was expressed predominantly by neoplastic cells, and its expression correlated positively with BPND in the tumors." | 1.42 | The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study. ( Brodbelt, A; Coope, DJ; Du Plessis, D; Durrenberger, PF; Gerhard, A; Herholz, K; Hinz, R; Jackson, A; Janczar, K; Karabatsou, K; Roncaroli, F; Su, Z; Thompson, G; Turkheimer, FE, 2015) |
| "We examined two anaplastic astrocytomas showing minimal contrast-enhancement and therefore little damage of the blood brain barrier to minimise the presence of blood borne macrophages within tumour tissue." | 1.34 | The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. ( Akiyama, H; Banati, RB; Deprez, M; Fukuyama, H; Hashikawa, K; Ishizu, K; Kawashima, H; Mottram, N; Roncaroli, F; Takaya, S; Turkheimer, FE, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, Z | 1 |
| Roncaroli, F | 2 |
| Durrenberger, PF | 1 |
| Coope, DJ | 1 |
| Karabatsou, K | 1 |
| Hinz, R | 1 |
| Thompson, G | 1 |
| Turkheimer, FE | 2 |
| Janczar, K | 1 |
| Du Plessis, D | 1 |
| Brodbelt, A | 1 |
| Jackson, A | 1 |
| Gerhard, A | 1 |
| Herholz, K | 1 |
| Chelli, B | 1 |
| Salvetti, A | 1 |
| Da Pozzo, E | 1 |
| Rechichi, M | 1 |
| Spinetti, F | 1 |
| Rossi, L | 1 |
| Costa, B | 1 |
| Lena, A | 1 |
| Rainaldi, G | 1 |
| Scatena, F | 1 |
| Vanacore, R | 1 |
| Gremigni, V | 1 |
| Martini, C | 1 |
| Dehnhardt, M | 1 |
| Palm, C | 1 |
| Vieten, A | 1 |
| Bauer, A | 1 |
| Pietrzyk, U | 1 |
| Takaya, S | 1 |
| Hashikawa, K | 1 |
| Mottram, N | 1 |
| Deprez, M | 1 |
| Ishizu, K | 1 |
| Kawashima, H | 1 |
| Akiyama, H | 1 |
| Fukuyama, H | 1 |
| Banati, RB | 1 |
| Miyazawa, N | 1 |
| Hamel, E | 1 |
| Diksic, M | 1 |
| Cornu, P | 1 |
| Benavides, J | 1 |
| Scatton, B | 1 |
| Hauw, JJ | 1 |
| Philippon, J | 1 |
| Ferrarese, C | 1 |
| Appollonio, I | 1 |
| Frigo, M | 1 |
| Gaini, SM | 1 |
| Piolti, R | 1 |
| Frattola, L | 1 |
7 other studies available for pk 11195 and Astrocytoma
| Article | Year |
|---|---|
The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Biomarkers, Tumor; Blood-Brain Barrier; Brain; Brain Neop | 2015 |
PK 11195 differentially affects cell survival in human wild-type and 18 kDa translocator protein-silenced ADF astrocytoma cells.
Topics: Antineoplastic Agents; Astrocytoma; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; | 2008 |
Quantifying the A1AR distribution in peritumoural zones around experimental F98 and C6 rat brain tumours.
Topics: Animals; Astrocytoma; Autoradiography; Brain Neoplasms; Caudate Nucleus; Cell Line, Tumor; Image Pro | 2007 |
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
Topics: Adult; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Female; Humans; Image Processing, Compu | 2007 |
Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods.
Topics: Astrocytoma; Autoradiography; Biomarkers, Tumor; Brain Neoplasms; Cell Differentiation; Glioma; Huma | 1998 |
Increase in omega 3 (peripheral-type benzodiazepine) binding site densities in different types of human brain tumours. A quantitative autoradiography study.
Topics: Astrocytoma; Autoradiography; Biomarkers, Tumor; Brain; Brain Neoplasms; Cerebellar Neoplasms; Gliom | 1992 |
Benzodiazepine receptors and diazepam-binding inhibitor in human cerebral tumors.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Diazepam Binding Inhibitor; Female; Fl | 1989 |