pk 11195 has been researched along with Astrocytoma, Grade IV in 11 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Herein, we report new quinazoline-urea based compounds with potent cytotoxic activities against TMZ-resistant glioblastoma multiforme (GBM) cells." | 7.81 | Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). ( Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H, 2015) |
| "Herein, we report new quinazoline-urea based compounds with potent cytotoxic activities against TMZ-resistant glioblastoma multiforme (GBM) cells." | 3.81 | Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). ( Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H, 2015) |
| "With the aid of the dye JC-1 and cyclosporin A, applied to glioblastoma cells, we now investigated the significance of opening of the mitochondrial permeability transition pore (MPTP) for ErPC3-induced apoptosis in interaction with the TSPO ligands, PK 11195 and Ro5 4864." | 3.74 | Ligands of the mitochondrial 18 kDa translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholine. ( Gavish, M; Kugler, W; Lakomek, M; Leschiner, S; Shandalov, Y; Spanier, I; Veenman, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cosimelli, B | 1 |
| Simorini, F | 1 |
| Taliani, S | 2 |
| La Motta, C | 1 |
| Da Settimo, F | 2 |
| Severi, E | 1 |
| Greco, G | 2 |
| Novellino, E | 2 |
| Costa, B | 2 |
| Da Pozzo, E | 2 |
| Bendinelli, S | 1 |
| Martini, C | 2 |
| Castellano, S | 1 |
| Viviano, M | 1 |
| Milite, C | 1 |
| Barresi, E | 1 |
| Bruno, A | 1 |
| Cosconati, S | 1 |
| Marinelli, L | 1 |
| Sbardella, G | 1 |
| Elkamhawy, A | 1 |
| Viswanath, AN | 1 |
| Pae, AN | 1 |
| Kim, HY | 1 |
| Heo, JC | 1 |
| Park, WK | 1 |
| Lee, CO | 1 |
| Yang, H | 1 |
| Kim, KH | 1 |
| Nam, DH | 1 |
| Seol, HJ | 1 |
| Cho, H | 1 |
| Roh, EJ | 1 |
| Denora, N | 1 |
| Lee, C | 1 |
| Iacobazzi, RM | 1 |
| Choi, JY | 1 |
| Song, IH | 1 |
| Yoo, JS | 1 |
| Piao, Y | 1 |
| Lopalco, A | 1 |
| Leonetti, F | 1 |
| Lee, BC | 1 |
| Kim, SE | 1 |
| Yasin, N | 1 |
| Veenman, L | 4 |
| Singh, S | 1 |
| Azrad, M | 1 |
| Bode, J | 2 |
| Vainshtein, A | 1 |
| Caballero, B | 2 |
| Marek, I | 1 |
| Gavish, M | 4 |
| Kugler, W | 2 |
| Shandalov, Y | 1 |
| Leschiner, S | 2 |
| Spanier, I | 1 |
| Lakomek, M | 2 |
| Zeno, S | 1 |
| Zaaroor, M | 1 |
| Brown, RC | 1 |
| Degenhardt, B | 1 |
| Kotoula, M | 1 |
| Papadopoulous, V | 1 |
| Pappata, S | 1 |
| Cornu, P | 2 |
| Samson, Y | 1 |
| Prenant, C | 1 |
| Benavides, J | 2 |
| Scatton, B | 2 |
| Crouzel, C | 1 |
| Hauw, JJ | 2 |
| Syrota, A | 1 |
| Dennis, T | 1 |
| Dubois, A | 1 |
| MacKenzie, ET | 1 |
| Sazdovitch, V | 1 |
11 other studies available for pk 11195 and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.
Topics: Amides; Cell Line, Tumor; Cyclization; Glioblastoma; Humans; Molecular Probes | 2011 |
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Computational Biol | 2014 |
Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship | 2015 |
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging.
Topics: Animals; Brain Neoplasms; Carbocyanines; Cell Line; Cell Survival; Ferric Compounds; Fluorescent Dye | 2019 |
Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling.
Topics: Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferati | 2017 |
Ligands of the mitochondrial 18 kDa translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholine.
Topics: Antineoplastic Agents; Apoptosis; Benzodiazepinones; Blotting, Western; Caspases; Cell Line, Tumor; | 2008 |
CoCl(2) induces apoptosis via the 18 kDa translocator protein in U118MG human glioblastoma cells.
Topics: Apoptosis; Cardiolipins; Cell Line, Tumor; Cobalt; Dose-Response Relationship, Drug; Gene Knockdown | 2009 |
The 18 kDa translocator protein influences angiogenesis, as well as aggressiveness, adhesion, migration, and proliferation of glioblastoma cells.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chick Embryo; Glioblast | 2012 |
Location-dependent role of the human glioma cell peripheral-type benzodiazepine receptor in proliferation and steroid biosynthesis.
Topics: Cell Division; Cell Nucleus; Glioblastoma; Humans; Isoquinolines; Kinetics; Mitochondria; Receptors, | 2000 |
PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report.
Topics: Aged; Brain Neoplasms; Carbon Radioisotopes; Glioblastoma; Humans; Isoquinolines; Male; Receptors, G | 1991 |
Imaging of human brain lesions with an omega 3 site radioligand.
Topics: Adult; Aged; Autoradiography; Brain; Brain Ischemia; Brain Neoplasms; Glioblastoma; Humans; Isoquino | 1988 |