pk 11195 has been researched along with Arthritis, Rheumatoid in 9 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, the effects of different peripheral benzodiazapine receptor ligands: PK 11195 [1-(2-chloro-phenyl)-N-methyl-N-(1-methylpropyl)-1-isoquinoline carboxamide], Ro5-4864 [7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one] and the newly described SSR 180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridozine[4,5-b] indole-1-acetamide) were analysed on the progression and severity of rheumatoid arthritis in vivo in the Mrl/lpr mice model, following chronic treatment (at 3 mg/kg, i." | 3.71 | Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice. ( Bourrie, B; Bribes, E; Casellas, P; Esclangon, M; Galiegue, S; Vidal, H, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gent, YY | 2 |
| Ahmadi, N | 2 |
| Voskuyl, AE | 4 |
| Hoetjes, N | 1 |
| van Kuijk, C | 2 |
| Britsemmer, K | 1 |
| Turkstra, F | 1 |
| Boers, M | 2 |
| Hoekstra, OS | 2 |
| van der Laken, CJ | 4 |
| Ter Wee, MM | 1 |
| den Uyl, D | 1 |
| Dowling, C | 1 |
| Lems, WF | 1 |
| Nozaki, S | 1 |
| Ozaki, N | 1 |
| Suzuki, S | 1 |
| Goto, M | 1 |
| Mawatari, A | 1 |
| Nakatani, Y | 1 |
| Hayashinaka, E | 1 |
| Wada, Y | 1 |
| Doi, H | 1 |
| Watanabe, Y | 1 |
| Narayan, N | 1 |
| Owen, DR | 1 |
| Taylor, PC | 1 |
| Elzinga, EH | 2 |
| Kropholler, MA | 2 |
| Molthoff, CF | 1 |
| van der Heijden, JW | 1 |
| Maruyama, K | 2 |
| Boellaard, R | 2 |
| Dijkmans, BA | 2 |
| Lammertsma, AA | 2 |
| Kloet, RW | 1 |
| Bribes, E | 1 |
| Bourrie, B | 1 |
| Esclangon, M | 1 |
| Galiegue, S | 1 |
| Vidal, H | 1 |
| Casellas, P | 1 |
| Giusti, L | 1 |
| Betti, L | 1 |
| Giannaccini, G | 1 |
| Mascia, G | 1 |
| Bazzichi, L | 1 |
| Lucacchini, A | 1 |
| Waterfield, JD | 1 |
| McGeer, EG | 1 |
| McGeer, PL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of a Novel PET Radioligand as an Inflammatory Biomarker in Musculoskeletal Conditions[NCT03912428] | Phase 1 | 111 participants (Anticipated) | Interventional | 2019-06-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pk 11195 and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Advances in positron emission tomography for the imaging of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Gallium Radioisotopes; | 2017 |
8 other studies available for pk 11195 and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Detection of subclinical synovitis with macrophage targeting and positron emission tomography in patients with rheumatoid arthritis without clinical arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cohort Studies; Contrast Media; Disease Progression; Female; Fin | 2014 |
Subclinical synovitis detected by macrophage PET, but not MRI, is related to short-term flare of clinical disease activity in early RA patients: an exploratory study.
Topics: Arthritis, Rheumatoid; Disease Progression; Female; Humans; Image Interpretation, Computer-Assisted; | 2015 |
Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [
Topics: Animals; Arthritis, Rheumatoid; Carbon Radioisotopes; Disease Models, Animal; Female; Imaging, Three | 2017 |
Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arthritis, Rheumatoid; Arthroscopy; Benzodi | 2008 |
Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritis.
Topics: Adult; Aged; Antineoplastic Agents; Arthritis, Rheumatoid; Carbon Radioisotopes; Female; Humans; Ima | 2009 |
Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice.
Topics: Acetamides; Animals; Antibodies, Blocking; Antirheumatic Agents; Arthritis, Rheumatoid; Benzodiazepi | 2002 |
[3H]PK11195 binding sites in human neutrophils: effect of fMLP stimulation and modulation in rheumatic diseases.
Topics: Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Binding Sites; Cell Membrane; Female; Humans; Iso | 2004 |
The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Models, Animal; Female; GABA-A Recepto | 1999 |