pk 11195 has been researched along with Anxiety in 19 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2." | 5.27 | Effect of PK 11195, an antagonist of benzodiazepine receptors, on platelet aggregation in a model of anxiety in the rat. ( Castillo, JR; Fernández-Alonso, A; Hevia, A; Serrano, JS, 1988) |
| " Rats received intra-VTA infusions of either PK11195 (400ng/mul, which inhibits de novo 3alpha,5alpha-THP production), indomethacin (10mug/mul, which blocks metabolism of P(4) to 3alpha,5alpha-THP), PK11195 and indomethacin together, or beta-cyclodextrin vehicle and tested on a battery of anxiety (open field and elevated plus maze), social (partner preference and social interaction), and sexual (paced mating) tasks." | 3.74 | Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area. ( Frye, CA; Paris, JJ; Rhodes, ME, 2008) |
| " The dual and complementary mechanisms of action of etifoxine (directly on the GABA A receptor and indirectly via the neuroactive steroids) may represent a therapeutic benefit in the treatment of various anxiety disorders with abnormal production of neuroactive steroids." | 3.74 | Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. ( Gillardin, JM; Heulard, I; Verleye, M, 2008) |
| "Ro 5-4864, a selective ligand for the benzodiazepine micromolar and peripheral receptors, had a significant dose-related (5-20 mg/kg) anxiogenic action in the social interaction test of anxiety." | 3.66 | The anxiogenic action of Ro 5-4864 is reversed by phenytoin. ( File, SE; Lister, RG, 1983) |
| "Allopregnanolone is a potent anxiolytic, anticonvulsant, sedative and hypnotic GABAergic neurosteroid." | 1.31 | Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat. ( Audette, D; Bitran, D; Foley, M; Frye, CA; Leslie, N, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, L | 1 |
| Wang, W | 1 |
| Zhang, LM | 2 |
| Jiang, XY | 1 |
| Sun, SZ | 1 |
| Sun, LJ | 1 |
| Guo, Y | 1 |
| Gong, J | 1 |
| Zhang, YZ | 2 |
| Wang, HL | 1 |
| Li, YF | 2 |
| Kaga, M | 1 |
| Nakamoto, Y | 2 |
| Nakamura, K | 2 |
| Ikeda, K | 1 |
| Yoshii, M | 2 |
| Kawana, S | 1 |
| Mokrov, GV | 2 |
| Deeva, OA | 2 |
| Gudasheva, TA | 2 |
| Yarkov, SA | 2 |
| Yarkova, MA | 2 |
| Seredenin, SB | 2 |
| Qiu, ZK | 1 |
| Chen, XF | 1 |
| Zhao, N | 1 |
| Chen, HX | 1 |
| Xue, R | 1 |
| Yang, RF | 1 |
| Wang, DS | 1 |
| Han, J | 1 |
| Li, S | 1 |
| Sun, T | 1 |
| Guo, YY | 1 |
| Kang, WB | 1 |
| Tian, Z | 1 |
| Zhao, JN | 1 |
| Liu, G | 1 |
| Liu, SB | 1 |
| Zhao, MG | 1 |
| Frye, CA | 3 |
| Paris, JJ | 2 |
| Rhodes, ME | 2 |
| Fukunishi, I | 1 |
| Iwahashi, K | 1 |
| Verleye, M | 1 |
| Heulard, I | 1 |
| Gillardin, JM | 1 |
| File, SE | 3 |
| Lister, RG | 1 |
| Mabbutt, PS | 1 |
| Becker, A | 1 |
| Gonzalez, LE | 1 |
| Fluck, E | 1 |
| Reddy, DS | 1 |
| Kulkarni, SK | 1 |
| Bitran, D | 1 |
| Foley, M | 1 |
| Audette, D | 1 |
| Leslie, N | 1 |
| Gavish, M | 2 |
| Katz, Y | 1 |
| Bar-Ami, S | 1 |
| Weizman, R | 2 |
| Holmes, PV | 1 |
| Drugan, RC | 1 |
| Serrano, JS | 1 |
| Hevia, A | 1 |
| Fernández-Alonso, A | 1 |
| Castillo, JR | 1 |
| Pellow, S | 1 |
| Tanne, Z | 1 |
| Granek, M | 1 |
| Karp, L | 1 |
| Golomb, M | 1 |
| Tyano, S | 1 |
1 review available for pk 11195 and Anxiety
| Article | Year |
|---|---|
Biochemical, physiological, and pathological aspects of the peripheral benzodiazepine receptor.
Topics: Animals; Anxiety; Benzodiazepinones; Endocrine Glands; Hormones; Humans; Isoquinolines; Ligands; Myo | 1992 |
18 other studies available for pk 11195 and Anxiety
| Article | Year |
|---|---|
Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Dentate Gyrus; Depression; Finasteride; Genetic Vect | 2017 |
Stress sensitivity in patients with atopic dermatitis in relation to the translocator protein 18 kDa (TSPO).
Topics: Alleles; Anxiety; Dermatitis, Atopic; Female; Gene Frequency; Genetic Predisposition to Disease; Gen | 2014 |
Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides.
Topics: Amides; Animals; Anti-Anxiety Agents; Anxiety; Binding Sites; Diazepam; Dose-Response Relationship, | 2015 |
The first dipeptide ligand of translocator protein: Design and anxiolytic activity.
Topics: Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety; Central Nervous System Agents; Dipe | 2015 |
Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Isoquinolines; Mal | 2016 |
Antidepressant-Like and Anxiolytic-Like Effects of ZBD-2, a Novel Ligand for the Translocator Protein (18 kDa).
Topics: Acetamides; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depression; Disease Models | 2017 |
Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area.
Topics: Animals; Antineoplastic Agents; Anxiety; Behavior, Animal; Cyclooxygenase Inhibitors; Desoxycorticos | 2008 |
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
Topics: Animals; Anxiety; Behavior, Animal; Exploratory Behavior; Female; Indoleacetic Acids; Indomethacin; | 2009 |
Peripheral-type benzodiazepine receptors on platelets are correlated with the degrees of anxiety in normal human subjects.
Topics: Adult; Anxiety; Binding, Competitive; Blood Platelets; Female; Humans; Isoquinolines; Male; Middle A | 2002 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convul | 2008 |
The anxiogenic action of Ro 5-4864 is reversed by phenytoin.
Topics: Animals; Anxiety; Benzodiazepinones; Humans; Interpersonal Relations; Isoquinolines; Male; Motor Act | 1983 |
Short-term rebound anxiolytic effects and long-term changes in platelet benzodiazepine binding after pentylenetetrazole-kindling in two strains of rat.
Topics: Animals; Anxiety; Arousal; Benzodiazepinones; Blood Platelets; Isoquinolines; Kindling, Neurologic; | 1996 |
Reversal of benzodiazepine inverse agonist FG 7142-induced anxiety syndrome by neurosteroids in mice.
Topics: Animals; Anxiety; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; GABA Antagonists; GABA | 1997 |
Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.
Topics: Analysis of Variance; Animals; Anxiety; GABA Antagonists; Hippocampus; Indoleacetic Acids; Isoquinol | 2000 |
Differential effects of anxiogenic central and peripheral benzodiazepine receptor ligands in tests of learning and memory.
Topics: Animals; Anxiety; Avoidance Learning; Benzodiazepinones; Carbolines; Conditioning, Operant; Isoquino | 1991 |
Effect of PK 11195, an antagonist of benzodiazepine receptors, on platelet aggregation in a model of anxiety in the rat.
Topics: Animals; Anxiety; Female; Isoquinolines; Male; Platelet Aggregation; Rats; Rats, Inbred Strains; Rec | 1988 |
The effects of PK 11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress.
Topics: Animals; Anxiety; Benzodiazepinones; Corticosterone; Disease Models, Animal; Drinking Behavior; Isoq | 1985 |
Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients.
Topics: Adult; Anxiety; Blood Platelets; Cell Membrane; Diazepam; Female; Humans; Isoquinolines; Kinetics; M | 1987 |