pk 11195 has been researched along with Amyotrophic Lateral Sclerosis in 4 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Turner, MR | 1 |
| Cagnin, A | 1 |
| Turkheimer, FE | 1 |
| Miller, CC | 1 |
| Shaw, CE | 1 |
| Brooks, DJ | 1 |
| Leigh, PN | 1 |
| Banati, RB | 1 |
| Yiangou, Y | 1 |
| Facer, P | 1 |
| Durrenberger, P | 1 |
| Chessell, IP | 1 |
| Naylor, A | 1 |
| Bountra, C | 1 |
| Banati, RR | 1 |
| Anand, P | 1 |
| Mills, C | 1 |
| Makwana, M | 1 |
| Wallace, A | 1 |
| Benn, S | 1 |
| Schmidt, H | 1 |
| Tegeder, I | 1 |
| Costigan, M | 1 |
| Brown, RH | 1 |
| Raivich, G | 1 |
| Woolf, CJ | 1 |
| Sitte, HH | 1 |
| Wanschitz, J | 1 |
| Budka, H | 1 |
| Berger, ML | 1 |
4 other studies available for pk 11195 and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.
Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; Humans; Isoquinolines; Male; Microglia; Middle | 2004 |
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.
Topics: Aged; Amyotrophic Lateral Sclerosis; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blotti | 2006 |
Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Axotomy; Benzodiazepinones; Blotting, Nort | 2008 |
Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Antineoplastic Agents; Autoradiography; Binding Sites; B | 2001 |