pk 11195 has been researched along with Alcoholism in 4 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of chronic alcoholism and detoxification treatment with disulfiram on platelet peripheral benzodiazepine receptors was studied in alcoholic males." | 3.68 | Peripheral benzodiazepine receptors on platelets in chronic and detoxified alcoholics. ( Fliman, M; Gavish, M; Karp, L; Tyano, S; Weizman, A, 1991) |
| "Alcohol abuse is the cause of many liver diseases, such as steatosis, alcoholic steatohepatitis, fibrosis, cirrhosis, and, potentially, hepatocellular cancer." | 1.56 | The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore. ( Baburina, Y; Krestinina, O; Odinokova, I, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baburina, Y | 1 |
| Odinokova, I | 1 |
| Krestinina, O | 1 |
| Wong, PT | 1 |
| Tan, CH | 1 |
| Kwan, MF | 1 |
| Ang, LK | 1 |
| Teo, WL | 1 |
| Karp, L | 1 |
| Weizman, A | 1 |
| Fliman, M | 1 |
| Tyano, S | 1 |
| Gavish, M | 1 |
| Suranyi-Cadotte, B | 1 |
| Lafaille, F | 1 |
| Dongier, M | 1 |
| Dumas, M | 1 |
| Quirion, R | 1 |
4 other studies available for pk 11195 and Alcoholism
| Article | Year |
|---|---|
The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore.
Topics: Alcoholism; Animals; Antineoplastic Agents; Humans; Isoquinolines; Mitochondria, Liver; Mitochondria | 2020 |
Effects of ethanol on peripheral benzodiazepine binding sites in the mouse cerebellum and brain stem.
Topics: Alcoholism; Animals; Benzodiazepines; Body Weight; Brain Stem; Cerebellum; Disease Models, Animal; D | 1995 |
Peripheral benzodiazepine receptors on platelets in chronic and detoxified alcoholics.
Topics: Adult; Alcoholism; Blood Platelets; Cell Membrane; Disulfiram; Humans; Isoquinolines; Male; Middle A | 1991 |
Decreased density of peripheral benzodiazepine binding sites on platelets of currently drinking, but not abstinent alcoholics.
Topics: Adult; Alcohol Drinking; Alcoholism; Binding Sites; Blood Platelets; Female; Humans; Isoquinolines; | 1988 |