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pk 11195 and Aging

pk 11195 has been researched along with Aging in 14 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's3 (21.43)18.2507
2000's3 (21.43)29.6817
2010's7 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Foucault-Fruchard, L1
Doméné, A1
Page, G1
Windsor, M1
Emond, P1
Rodrigues, N1
Dollé, F1
Damont, A1
Buron, F1
Routier, S1
Chalon, S1
Antier, D1
Christensen, A1
Pike, CJ1
Kumar, A3
Williams, MT1
Chugani, HT3
Yokokura, M1
Terada, T1
Bunai, T1
Nakaizumi, K1
Takebayashi, K1
Iwata, Y1
Yoshikawa, E1
Futatsubashi, M1
Suzuki, K1
Mori, N1
Ouchi, Y1
Muzik, O2
Chugani, D2
Chakraborty, P2
Schuitemaker, A2
van der Doef, TF1
Boellaard, R2
van der Flier, WM1
Yaqub, M1
Windhorst, AD1
Barkhof, F1
Jonker, C2
Kloet, RW1
Lammertsma, AA2
Scheltens, P2
van Berckel, BN2
Shandal, V1
Chen, CF1
Lang, SY1
Zuo, PP1
Yang, N1
Wang, XQ1
Xia, C1
Kropholler, MA1
Veltman, DJ1
Venneti, S1
Lopresti, BJ1
Wang, G1
Hamilton, RL1
Mathis, CA1
Klunk, WE1
Apte, UM1
Wiley, CA1
Nomura, Y1
Yamanaka, Y1
Kitamura, Y1
Arima, T1
Ohnuki, T1
Oomura, Y1
Sasaki, K1
Nagashima, K1
Ihara, Y1
Zilz, A1
Li, H1
Castello, R1
Papadopoulos, V1
Widmaier, EP1
Benavides, J1
Capdeville, C1
Dauphin, F1
Dubois, A1
Duverger, D1
Fage, D1
Gotti, B1
MacKenzie, ET1
Scatton, B1
Fares, F1
Weizman, A1
Zlotogorski, D1
Gavish, M1

Other Studies

14 other studies available for pk 11195 and Aging

ArticleYear
Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model.
    Neuroscience, 2017, 07-25, Volume: 356

    Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Is

2017
TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice.
    Neuroscience letters, 2018, 09-14, Volume: 683

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Female; Isoquinolines; Ligands; Maz

2018
Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and tourette syndrome: a positron emission tomographic (PET) study using 11C-[R]-PK11195.
    Journal of child neurology, 2015, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Aging; Autoimmune Diseases; Basal Ganglia; Carbon Radioisotopes; Child; Humans; I

2015
Depiction of microglial activation in aging and dementia: Positron emission tomography with [
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:3

    Topics: Acetamides; Aged; Aging; Alzheimer Disease; Brain; Carbon Radioisotopes; Dementia; Humans; Isoquinol

2017
PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Female; Humans; Image Processing, Computer-Assist

2010
Microglial activation in healthy aging.
    Neurobiology of aging, 2012, Volume: 33, Issue:6

    Topics: Adult; Aged; Aging; Brain; Cellular Senescence; Female; Humans; Isoquinolines; Male; Microglia; Midd

2012
Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET.
    Journal of neuroinflammation, 2012, Oct-04, Volume: 9

    Topics: Adolescent; Adult; Aging; Analysis of Variance; Antineoplastic Agents; Brain; Brain Mapping; Carbon

2012
Effects of D-galactose on the expression of hippocampal peripheral-type benzodiazepine receptor and spatial memory performances in rats.
    Psychoneuroendocrinology, 2006, Volume: 31, Issue:7

    Topics: Aging; Animals; Female; Galactose; Hippocampus; Isoquinolines; Male; Maze Learning; Models, Animal;

2006
SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods.
    NeuroImage, 2007, May-01, Volume: 35, Issue:4

    Topics: Adult; Aged; Aging; Brain; Data Interpretation, Statistical; Female; Functional Laterality; Humans;

2007
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.
    Neurobiology of aging, 2009, Volume: 30, Issue:8

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocyt

2009
Senescence-accelerated mouse. Neurochemical studies on aging.
    Annals of the New York Academy of Sciences, 1996, Jun-15, Volume: 786

    Topics: Aging; Animals; Antibodies; Blotting, Northern; Blotting, Western; Brain; Immunohistochemistry; Isoq

1996
Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands.
    Endocrinology, 1999, Volume: 140, Issue:2

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aging; Animals; Animals, Newborn; Female; Hormones; Iso

1999
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.
    Brain research, 1990, Jul-09, Volume: 522, Issue:2

    Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Iso

1990
Ontogenetic development of peripheral benzodiazepine binding sites in rat brain, heart and lung.
    Brain research, 1987, Apr-07, Volume: 408, Issue:1-2

    Topics: Aging; Animals; Brain; Female; Heart; Isoquinolines; Kinetics; Lung; Male; Myocardium; Rats; Rats, I

1987