pk 11195 has been researched along with Aging in 14 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Foucault-Fruchard, L | 1 |
| Doméné, A | 1 |
| Page, G | 1 |
| Windsor, M | 1 |
| Emond, P | 1 |
| Rodrigues, N | 1 |
| Dollé, F | 1 |
| Damont, A | 1 |
| Buron, F | 1 |
| Routier, S | 1 |
| Chalon, S | 1 |
| Antier, D | 1 |
| Christensen, A | 1 |
| Pike, CJ | 1 |
| Kumar, A | 3 |
| Williams, MT | 1 |
| Chugani, HT | 3 |
| Yokokura, M | 1 |
| Terada, T | 1 |
| Bunai, T | 1 |
| Nakaizumi, K | 1 |
| Takebayashi, K | 1 |
| Iwata, Y | 1 |
| Yoshikawa, E | 1 |
| Futatsubashi, M | 1 |
| Suzuki, K | 1 |
| Mori, N | 1 |
| Ouchi, Y | 1 |
| Muzik, O | 2 |
| Chugani, D | 2 |
| Chakraborty, P | 2 |
| Schuitemaker, A | 2 |
| van der Doef, TF | 1 |
| Boellaard, R | 2 |
| van der Flier, WM | 1 |
| Yaqub, M | 1 |
| Windhorst, AD | 1 |
| Barkhof, F | 1 |
| Jonker, C | 2 |
| Kloet, RW | 1 |
| Lammertsma, AA | 2 |
| Scheltens, P | 2 |
| van Berckel, BN | 2 |
| Shandal, V | 1 |
| Chen, CF | 1 |
| Lang, SY | 1 |
| Zuo, PP | 1 |
| Yang, N | 1 |
| Wang, XQ | 1 |
| Xia, C | 1 |
| Kropholler, MA | 1 |
| Veltman, DJ | 1 |
| Venneti, S | 1 |
| Lopresti, BJ | 1 |
| Wang, G | 1 |
| Hamilton, RL | 1 |
| Mathis, CA | 1 |
| Klunk, WE | 1 |
| Apte, UM | 1 |
| Wiley, CA | 1 |
| Nomura, Y | 1 |
| Yamanaka, Y | 1 |
| Kitamura, Y | 1 |
| Arima, T | 1 |
| Ohnuki, T | 1 |
| Oomura, Y | 1 |
| Sasaki, K | 1 |
| Nagashima, K | 1 |
| Ihara, Y | 1 |
| Zilz, A | 1 |
| Li, H | 1 |
| Castello, R | 1 |
| Papadopoulos, V | 1 |
| Widmaier, EP | 1 |
| Benavides, J | 1 |
| Capdeville, C | 1 |
| Dauphin, F | 1 |
| Dubois, A | 1 |
| Duverger, D | 1 |
| Fage, D | 1 |
| Gotti, B | 1 |
| MacKenzie, ET | 1 |
| Scatton, B | 1 |
| Fares, F | 1 |
| Weizman, A | 1 |
| Zlotogorski, D | 1 |
| Gavish, M | 1 |
14 other studies available for pk 11195 and Aging
| Article | Year |
|---|---|
Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model.
Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Is | 2017 |
TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Female; Isoquinolines; Ligands; Maz | 2018 |
Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and tourette syndrome: a positron emission tomographic (PET) study using 11C-[R]-PK11195.
Topics: Adolescent; Adult; Aging; Autoimmune Diseases; Basal Ganglia; Carbon Radioisotopes; Child; Humans; I | 2015 |
Depiction of microglial activation in aging and dementia: Positron emission tomography with [
Topics: Acetamides; Aged; Aging; Alzheimer Disease; Brain; Carbon Radioisotopes; Dementia; Humans; Isoquinol | 2017 |
PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Female; Humans; Image Processing, Computer-Assist | 2010 |
Microglial activation in healthy aging.
Topics: Adult; Aged; Aging; Brain; Cellular Senescence; Female; Humans; Isoquinolines; Male; Microglia; Midd | 2012 |
Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET.
Topics: Adolescent; Adult; Aging; Analysis of Variance; Antineoplastic Agents; Brain; Brain Mapping; Carbon | 2012 |
Effects of D-galactose on the expression of hippocampal peripheral-type benzodiazepine receptor and spatial memory performances in rats.
Topics: Aging; Animals; Female; Galactose; Hippocampus; Isoquinolines; Male; Maze Learning; Models, Animal; | 2006 |
SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods.
Topics: Adult; Aged; Aging; Brain; Data Interpretation, Statistical; Female; Functional Laterality; Humans; | 2007 |
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocyt | 2009 |
Senescence-accelerated mouse. Neurochemical studies on aging.
Topics: Aging; Animals; Antibodies; Blotting, Northern; Blotting, Western; Brain; Immunohistochemistry; Isoq | 1996 |
Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aging; Animals; Animals, Newborn; Female; Hormones; Iso | 1999 |
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.
Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Iso | 1990 |
Ontogenetic development of peripheral benzodiazepine binding sites in rat brain, heart and lung.
Topics: Aging; Animals; Brain; Female; Heart; Isoquinolines; Kinetics; Lung; Male; Myocardium; Rats; Rats, I | 1987 |