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pk 11195 and Acute Necrotizing Encephalitis, Herpetic

pk 11195 has been researched along with Acute Necrotizing Encephalitis, Herpetic in 3 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Research Excerpts

ExcerptRelevanceReference
" Despite its use in clinical research, no studies on the imaging properties and pharmacokinetic analysis of (11)C-PBR28 in rodent models of neuroinflammation have been published yet."1.43Pharmacokinetic Analysis of 11C-PBR28 in the Rat Model of Herpes Encephalitis: Comparison with (R)-11C-PK11195. ( de Vries, EF; Dierckx, RA; Doorduin, J; Feltes, PK; Moriguchi Jeckel, CM; Parente, A; Sijbesma, JW; Vállez García, D, 2016)
"Two patients with asymmetrical herpes simplex encephalitis were serially scanned 6 and 12 months after the acute illness using PET with [11C] (R)-PK11195, a marker of activated microglia/brain macrophages."1.31In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. ( Banati, RB; Cagnin, A; Gunn, RN; Jones, T; Kreutzberg, GW; Lawrence, AD; Myers, R; Stevens, T, 2001)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Parente, A1
Feltes, PK1
Vállez García, D1
Sijbesma, JW1
Moriguchi Jeckel, CM1
Dierckx, RA2
de Vries, EF2
Doorduin, J2
Antunes, IF1
Haisma, HJ1
Elsinga, PH1
van Waarde, A1
Willemsen, AT1
Cagnin, A1
Myers, R1
Gunn, RN1
Lawrence, AD1
Stevens, T1
Kreutzberg, GW1
Jones, T1
Banati, RB1

Other Studies

3 other studies available for pk 11195 and Acute Necrotizing Encephalitis, Herpetic

ArticleYear
Pharmacokinetic Analysis of 11C-PBR28 in the Rat Model of Herpes Encephalitis: Comparison with (R)-11C-PK11195.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:5

    Topics: Animals; Biological Transport; Disease Models, Animal; Encephalitis, Herpes Simplex; Image Processin

2016
18F-FEAnGA for PET of β-glucuronidase activity in neuroinflammation.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:3

    Topics: Animals; Benzyl Alcohols; Biotransformation; Brain; Encephalitis, Herpes Simplex; Glucuronates; Gluc

2012
In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion.
    Brain : a journal of neurology, 2001, Volume: 124, Issue:Pt 10

    Topics: Adult; Aged; Aged, 80 and over; Binding Sites; Brain; Carbon Radioisotopes; Chi-Square Distribution;

2001