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pk 11195 and Absence Seizure

pk 11195 has been researched along with Absence Seizure in 19 studies

PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine

Research Excerpts

ExcerptRelevanceReference
" In the present study, rats received intraperitoneal kainic acid injections, which are known to cause seizures, neurodegeneration, hyperactivity, gliosis, and a fivefold increase in PBR ligand binding density in the hippocampus."7.71PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. ( Gavish, M; Leschiner, S; Spanier, I; Veenman, L; Weisinger, G; Weizman, A, 2002)
"Two compounds with high affinity for the "peripheral type" benzodiazepine binding sites, PK 11195 (an isoquinoline derivative) and RO5-4864 (a benzodiazepine derivative) can modify the sensitivity of DBA/2J mice to audiogenic seizures."7.67Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice. ( Allam, DE; Bénavidès, J; Dubroeucq, MC; Guérémy, C; Guilloux, F; Le Fur, G; Mizoule, J; Renault, C; Uzan, A, 1984)
" The dual and complementary mechanisms of action of etifoxine (directly on the GABA A receptor and indirectly via the neuroactive steroids) may represent a therapeutic benefit in the treatment of various anxiety disorders with abnormal production of neuroactive steroids."3.74Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. ( Gillardin, JM; Heulard, I; Verleye, M, 2008)
" In the present study, rats received intraperitoneal kainic acid injections, which are known to cause seizures, neurodegeneration, hyperactivity, gliosis, and a fivefold increase in PBR ligand binding density in the hippocampus."3.71PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. ( Gavish, M; Leschiner, S; Spanier, I; Veenman, L; Weisinger, G; Weizman, A, 2002)
"Rats were tested for anticonvulsant responsivity to agents active at central and peripheral-type benzodiazepine receptors before and after they were made tolerant to the anticonvulsant effects of carbamazepine on amygdala-kindled seizures."3.68Contingent tolerance to carbamazepine: a peripheral-type benzodiazepine mechanism. ( Post, RM; Weiss, SR, 1991)
" PK 11195 (up to 120 mg kg-1) was ineffective at counteracting seizures caused by the convulsant benzodiazepine Ro 5-3663, although this dose did increase the latency to seize after injection with pentylenetetrazole."3.67Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance. ( File, SE, 1984)
"Two compounds with high affinity for the "peripheral type" benzodiazepine binding sites, PK 11195 (an isoquinoline derivative) and RO5-4864 (a benzodiazepine derivative) can modify the sensitivity of DBA/2J mice to audiogenic seizures."3.67Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice. ( Allam, DE; Bénavidès, J; Dubroeucq, MC; Guérémy, C; Guilloux, F; Le Fur, G; Mizoule, J; Renault, C; Uzan, A, 1984)
"The present study was designed to investigate whether D,L-laudanosine (a breakdown product of the neuromuscular relaxant atracurium besylate) interacts with benzodiazepinergic receptors or muscarinic receptors, both of which are involved in epilepsy and other types of seizures."3.67Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors. ( Gavish, M; Katz, Y, 1989)
"Midazolam is a short-acting benzodiazepine that is widely used as an i."1.38Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012)
"When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex."1.31The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. ( Holtman, JR; Jing, X; Sloan, JW; Wala, EP, 2000)
" FLU evoked dose-related tonic-clonic and clonic convulsions (five out of six rats), whereas PK (10 mg/kg) induced convulsions in only one rat (out of five); tachypnea tended to increase with the dose of both FLU and PK; twitches and jerks, backing and writhing had a significant regression on the dose of FLU; rearing tended to decrease with the dose of PK whereas FLU-evoked head bobbing and PK-evoked twitches and jerks had inverse U-shaped dose-response curves."1.30Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats. ( Jing, X; Sloan, JW; Wala, EP, 1997)
"Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine."1.28Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19905 (26.32)18.7374
1990's7 (36.84)18.2507
2000's5 (26.32)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gunia-Krzyżak, A1
Żelaszczyk, D1
Rapacz, A1
Żesławska, E1
Waszkielewicz, AM1
Pańczyk, K1
Słoczyńska, K1
Pękala, E1
Nitek, W1
Filipek, B1
Marona, H1
Self, RL1
Smith, KJ1
Butler, TR1
Pauly, JR1
Prendergast, MA1
Dhir, A1
Rogawski, MA1
Chen, C1
Lang, S1
Xu, G1
Liu, X1
Zuo, P1
Verleye, M1
Heulard, I1
Gillardin, JM1
File, SE1
Bénavidès, J1
Guilloux, F1
Allam, DE1
Uzan, A1
Mizoule, J1
Renault, C1
Dubroeucq, MC1
Guérémy, C1
Le Fur, G1
Zisterer, DM1
Suñol, C1
Moynagh, PN1
Williams, DC1
Rodríguez-Farré, E1
Auta, J1
Romeo, E1
Kozikowski, A1
Ma, D1
Costa, E1
Guidotti, A1
Byrnes, JJ1
Miller, LG1
Perkins, K1
Greenblatt, DJ1
Shader, RI1
Lallement, G1
Delamanche, IS1
Pernot-Marino, I1
Baubichon, D1
Denoyer, M1
Carpentier, P1
Blanchet, G1
Wala, EP2
Sloan, JW2
Jing, X2
Holtman, JR1
Veenman, L1
Leschiner, S1
Spanier, I1
Weisinger, G1
Weizman, A1
Gavish, M2
Weiss, SR1
Post, RM1
Dolin, SJ1
Patch, TL1
Rabbani, M1
Taberner, PV1
Little, HJ1
Katz, Y1
Valin, A1
Bryere, P1
Naquet, R1
Devaud, LL1
Szot, P1
Murray, TF1

Other Studies

19 other studies available for pk 11195 and Absence Seizure

ArticleYear
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo

2017
Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial
    Neuroscience, 2009, Oct-20, Volume: 163, Issue:3

    Topics: Animals; Autoradiography; Dizocilpine Maleate; Ethanol; Hippocampus; Injections, Intraventricular; I

2009
Role of neurosteroids in the anticonvulsant activity of midazolam.
    British journal of pharmacology, 2012, Volume: 165, Issue:8

    Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani

2012
Effects of topiramate on seizure susceptibility in kainate-kindled rats: involvement of peripheral-type benzodiazepine receptors.
    Seizure, 2008, Volume: 17, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Excitatory Amino Acid Agonists; Fructose; Hippocampus; I

2008
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
    Psychopharmacology, 2008, Volume: 197, Issue:4

    Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convul

2008
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
    British journal of pharmacology, 1984, Volume: 83, Issue:2

    Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Toleranc

1984
Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice.
    Life sciences, 1984, Jun-25, Volume: 34, Issue:26

    Topics: Acoustic Stimulation; Animals; Benzodiazepinones; Convulsants; Dose-Response Relationship, Drug; Iso

1984
PK 11195 reduces the brain availability of lindane in rats and the convulsions induced by this neurotoxic agent.
    Life sciences, 1995, Volume: 57, Issue:25

    Topics: Animals; Biological Availability; Brain; Hexachlorocyclohexane; Isoquinolines; Male; Rats; Rats, Wis

1995
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2

    Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal;

1993
Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1993, Volume: 8, Issue:3

    Topics: Animals; Benzodiazepinones; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; GABA-A R

1993
Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage: quantification with an omega 3 site ligand.
    Brain research, 1993, Aug-06, Volume: 618, Issue:2

    Topics: Animals; Autoradiography; Benzoxazines; Brain; Brain Diseases; Excitatory Amino Acid Antagonists; Hi

1993
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
    Psychopharmacology, 1997, Volume: 133, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Dr

1997
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazeni

2000
PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain.
    Journal of neurochemistry, 2002, Volume: 80, Issue:5

    Topics: Animals; Behavior, Animal; Binding, Competitive; Blotting, Western; Hippocampus; Hyperkinesis; Isoqu

2002
Contingent tolerance to carbamazepine: a peripheral-type benzodiazepine mechanism.
    European journal of pharmacology, 1991, Feb-07, Volume: 193, Issue:2

    Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Drug Tolerance; Isoquinolines; Kindling, Neurolog

1991
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
    Neuropharmacology, 1991, Volume: 30, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1991
Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors.
    Anesthesiology, 1989, Volume: 70, Issue:1

    Topics: Animals; Benzodiazepinones; Cerebral Cortex; Flunitrazepam; Isoquinolines; Kidney; Quinuclidinyl Ben

1989
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
    Neuroscience letters, 1986, May-15, Volume: 66, Issue:2

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug;

1986
PK 11195 antagonism of pyrethroid-induced proconvulsant activity.
    European journal of pharmacology, 1986, Feb-18, Volume: 121, Issue:2

    Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Isoquinolines; Male; Nitriles; Pentylenetetr

1986