pk 11195 has been researched along with Absence Seizure in 19 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
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" In the present study, rats received intraperitoneal kainic acid injections, which are known to cause seizures, neurodegeneration, hyperactivity, gliosis, and a fivefold increase in PBR ligand binding density in the hippocampus." | 7.71 | PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. ( Gavish, M; Leschiner, S; Spanier, I; Veenman, L; Weisinger, G; Weizman, A, 2002) |
"Two compounds with high affinity for the "peripheral type" benzodiazepine binding sites, PK 11195 (an isoquinoline derivative) and RO5-4864 (a benzodiazepine derivative) can modify the sensitivity of DBA/2J mice to audiogenic seizures." | 7.67 | Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice. ( Allam, DE; Bénavidès, J; Dubroeucq, MC; Guérémy, C; Guilloux, F; Le Fur, G; Mizoule, J; Renault, C; Uzan, A, 1984) |
" The dual and complementary mechanisms of action of etifoxine (directly on the GABA A receptor and indirectly via the neuroactive steroids) may represent a therapeutic benefit in the treatment of various anxiety disorders with abnormal production of neuroactive steroids." | 3.74 | Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. ( Gillardin, JM; Heulard, I; Verleye, M, 2008) |
" In the present study, rats received intraperitoneal kainic acid injections, which are known to cause seizures, neurodegeneration, hyperactivity, gliosis, and a fivefold increase in PBR ligand binding density in the hippocampus." | 3.71 | PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. ( Gavish, M; Leschiner, S; Spanier, I; Veenman, L; Weisinger, G; Weizman, A, 2002) |
"Rats were tested for anticonvulsant responsivity to agents active at central and peripheral-type benzodiazepine receptors before and after they were made tolerant to the anticonvulsant effects of carbamazepine on amygdala-kindled seizures." | 3.68 | Contingent tolerance to carbamazepine: a peripheral-type benzodiazepine mechanism. ( Post, RM; Weiss, SR, 1991) |
" PK 11195 (up to 120 mg kg-1) was ineffective at counteracting seizures caused by the convulsant benzodiazepine Ro 5-3663, although this dose did increase the latency to seize after injection with pentylenetetrazole." | 3.67 | Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance. ( File, SE, 1984) |
"Two compounds with high affinity for the "peripheral type" benzodiazepine binding sites, PK 11195 (an isoquinoline derivative) and RO5-4864 (a benzodiazepine derivative) can modify the sensitivity of DBA/2J mice to audiogenic seizures." | 3.67 | Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice. ( Allam, DE; Bénavidès, J; Dubroeucq, MC; Guérémy, C; Guilloux, F; Le Fur, G; Mizoule, J; Renault, C; Uzan, A, 1984) |
"The present study was designed to investigate whether D,L-laudanosine (a breakdown product of the neuromuscular relaxant atracurium besylate) interacts with benzodiazepinergic receptors or muscarinic receptors, both of which are involved in epilepsy and other types of seizures." | 3.67 | Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors. ( Gavish, M; Katz, Y, 1989) |
"Midazolam is a short-acting benzodiazepine that is widely used as an i." | 1.38 | Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012) |
"When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex." | 1.31 | The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. ( Holtman, JR; Jing, X; Sloan, JW; Wala, EP, 2000) |
" FLU evoked dose-related tonic-clonic and clonic convulsions (five out of six rats), whereas PK (10 mg/kg) induced convulsions in only one rat (out of five); tachypnea tended to increase with the dose of both FLU and PK; twitches and jerks, backing and writhing had a significant regression on the dose of FLU; rearing tended to decrease with the dose of PK whereas FLU-evoked head bobbing and PK-evoked twitches and jerks had inverse U-shaped dose-response curves." | 1.30 | Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats. ( Jing, X; Sloan, JW; Wala, EP, 1997) |
"Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine." | 1.28 | Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991) |
Timeframe | Studies, this research(%) | All Research% |
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pre-1990 | 5 (26.32) | 18.7374 |
1990's | 7 (36.84) | 18.2507 |
2000's | 5 (26.32) | 29.6817 |
2010's | 2 (10.53) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Gunia-Krzyżak, A | 1 |
Żelaszczyk, D | 1 |
Rapacz, A | 1 |
Żesławska, E | 1 |
Waszkielewicz, AM | 1 |
Pańczyk, K | 1 |
Słoczyńska, K | 1 |
Pękala, E | 1 |
Nitek, W | 1 |
Filipek, B | 1 |
Marona, H | 1 |
Self, RL | 1 |
Smith, KJ | 1 |
Butler, TR | 1 |
Pauly, JR | 1 |
Prendergast, MA | 1 |
Dhir, A | 1 |
Rogawski, MA | 1 |
Chen, C | 1 |
Lang, S | 1 |
Xu, G | 1 |
Liu, X | 1 |
Zuo, P | 1 |
Verleye, M | 1 |
Heulard, I | 1 |
Gillardin, JM | 1 |
File, SE | 1 |
Bénavidès, J | 1 |
Guilloux, F | 1 |
Allam, DE | 1 |
Uzan, A | 1 |
Mizoule, J | 1 |
Renault, C | 1 |
Dubroeucq, MC | 1 |
Guérémy, C | 1 |
Le Fur, G | 1 |
Zisterer, DM | 1 |
Suñol, C | 1 |
Moynagh, PN | 1 |
Williams, DC | 1 |
Rodríguez-Farré, E | 1 |
Auta, J | 1 |
Romeo, E | 1 |
Kozikowski, A | 1 |
Ma, D | 1 |
Costa, E | 1 |
Guidotti, A | 1 |
Byrnes, JJ | 1 |
Miller, LG | 1 |
Perkins, K | 1 |
Greenblatt, DJ | 1 |
Shader, RI | 1 |
Lallement, G | 1 |
Delamanche, IS | 1 |
Pernot-Marino, I | 1 |
Baubichon, D | 1 |
Denoyer, M | 1 |
Carpentier, P | 1 |
Blanchet, G | 1 |
Wala, EP | 2 |
Sloan, JW | 2 |
Jing, X | 2 |
Holtman, JR | 1 |
Veenman, L | 1 |
Leschiner, S | 1 |
Spanier, I | 1 |
Weisinger, G | 1 |
Weizman, A | 1 |
Gavish, M | 2 |
Weiss, SR | 1 |
Post, RM | 1 |
Dolin, SJ | 1 |
Patch, TL | 1 |
Rabbani, M | 1 |
Taberner, PV | 1 |
Little, HJ | 1 |
Katz, Y | 1 |
Valin, A | 1 |
Bryere, P | 1 |
Naquet, R | 1 |
Devaud, LL | 1 |
Szot, P | 1 |
Murray, TF | 1 |
19 other studies available for pk 11195 and Absence Seizure
Article | Year |
---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial
Topics: Animals; Autoradiography; Dizocilpine Maleate; Ethanol; Hippocampus; Injections, Intraventricular; I | 2009 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani | 2012 |
Effects of topiramate on seizure susceptibility in kainate-kindled rats: involvement of peripheral-type benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Excitatory Amino Acid Agonists; Fructose; Hippocampus; I | 2008 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convul | 2008 |
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Toleranc | 1984 |
Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice.
Topics: Acoustic Stimulation; Animals; Benzodiazepinones; Convulsants; Dose-Response Relationship, Drug; Iso | 1984 |
PK 11195 reduces the brain availability of lindane in rats and the convulsions induced by this neurotoxic agent.
Topics: Animals; Biological Availability; Brain; Hexachlorocyclohexane; Isoquinolines; Male; Rats; Rats, Wis | 1995 |
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; | 1993 |
Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; GABA-A R | 1993 |
Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage: quantification with an omega 3 site ligand.
Topics: Animals; Autoradiography; Benzoxazines; Brain; Brain Diseases; Excitatory Amino Acid Antagonists; Hi | 1993 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Dr | 1997 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazeni | 2000 |
PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain.
Topics: Animals; Behavior, Animal; Binding, Competitive; Blotting, Western; Hippocampus; Hyperkinesis; Isoqu | 2002 |
Contingent tolerance to carbamazepine: a peripheral-type benzodiazepine mechanism.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Drug Tolerance; Isoquinolines; Kindling, Neurolog | 1991 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Flunitrazepam; Isoquinolines; Kidney; Quinuclidinyl Ben | 1989 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; | 1986 |
PK 11195 antagonism of pyrethroid-induced proconvulsant activity.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Isoquinolines; Male; Nitriles; Pentylenetetr | 1986 |