pituitrin and Tuberculosis

Hyponatremia and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) are associated with and can be caused by tuberculosis (TB) through meningitis by locally invading the hypothalamus, adrenal, or pituitary glands or possibly through ectopic ADH production. This study assessed the association of TB mortality with hyponatremia and SIADH in a large cohort of a university hospital in Austria.. This retrospective study enrolled patients with hyponatremia and patients diagnosed with TB from 01/2001-11/2019 to assess the prevalence of TB in hyponatremia and TB morbidity and mortality in patients with and without hyponatremia. Sex, age, microbiological results, laboratory tests and comorbidities were analysed and used to calculate survival rates.. Of 107.532 patients with hyponatremia (0.07%) and 186 patients with TB (43%), 80 patients were diagnosed with both-hyponatremia and TB. Only three TB patients had SIADH, precluding further SIADH analysis. In hyponatremia, young age and high CRP levels showed significant associations with TB diagnosis (p<0.0001). Survival rates of patients diagnosed with TB with moderate to profound hyponatremia were significantly lower than those without hyponatremia (p = 0.002).. In this study of a large cohort from a tertiary care hospital in a non-endemic area of TB, 0.07% of patients presenting with hyponatremia, but especially younger patients and patients with high CRP values, were diagnosed with TB. Crucially, patients with moderate to profound hyponatremia had a significantly higher mortality rate and thus required increased medical care.

Topics: Humans; Hyponatremia; Inappropriate ADH Syndrome; Retrospective Studies; Tuberculosis; Vasopressins

Topics: Addison Disease; Adrenal Glands; Humans; Hyponatremia; Male; Middle Aged; Tuberculosis; Vasopressins

A patient with ectopic pinealoma first presented with apparent anorexia nervosa and hypernatraemic coma. A history of diabetes insipidus two months previously was not known on admission to hospital. The diabetes insipidus was unmasked by the administration of steroids. Neuroendocrinal and neuropathological aspects of the case are discussed with reference to the march of symptoms due to the growth of the tumour. Histochemical evidence is presented supporting the similarity between ectopic pinealoma and seminoma which suggests that they may more properly be referred to as atypical teratomas.

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Anorexia Nervosa; Brain Neoplasms; Coma; Diabetes Insipidus; Dihydrolipoamide Dehydrogenase; Dysgerminoma; Electron Transport Complex IV; Esterases; Female; Humans; Hydrocortisone; Hypernatremia; Hypothalamus; Male; Osmolar Concentration; Oxidoreductases; Pinealoma; Sodium; Testicular Neoplasms; Thyroxine; Tuberculosis; Vasopressins

Topics: Aged; Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Pituitary Diseases; Tuberculosis; Vasopressins

Topics: Adolescent; Adult; Aged; Aldosterone; Blood Glucose; Fasting; Fever; Glomerular Filtration Rate; Glucose; Humans; Hyponatremia; Insulin; Middle Aged; Natriuresis; Neoplasms; Osmolar Concentration; Sodium; Tuberculosis; Vasopressins

Topics: Ascites; Biomedical Research; Blood Gas Analysis; Blood Pressure; Bronchiectasis; Cardiovascular System; Heart; Oxytocin; Peptides; Pharmacology; Pulmonary Circulation; Pulmonary Emphysema; Pulmonary Fibrosis; Pulse; Respiration; Tuberculosis; Tuberculosis, Pulmonary; Vasopressins

Topics: Blood Coagulation; Bronchiectasis; Bronchitis; Capillary Permeability; Diagnosis, Differential; Hemoptysis; Humans; Lung Neoplasms; Menstrual Hygiene Products; Pathology; Pharmacology; Pituitary Hormones, Posterior; Sympathomimetics; Tampons, Surgical; Tracheitis; Tuberculosis; Tuberculosis, Pulmonary; Vasopressins

Topics: Blood Circulation; Blood Gas Analysis; Blood Pressure; Cardiac Catheterization; Cardiovascular System; Felypressin; Heart Function Tests; Injections, Subcutaneous; Pharmacology; Pulmonary Artery; Tuberculosis; Tuberculosis, Pulmonary; Vasopressins