pituitrin and Teratoma

Hyponatremia is often caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Hypersecretion of vasopressin from malignant tumors can be considered a cause of SIADH. Most of these ectopic productions of vasopressin are complications of small cell lung cancer. Cases concomitant with ovarian tumors are very rare, and a specific causative substance from the ovary is often unknown. A 16-year-old woman was diagnosed with an ovarian tumor. She developed hyponatremia that was resistant to medical treatment, but immediately improved after surgical resection of the tumor. Her diagnosis was SIADH caused by an ovarian tumor; however, her serum vasopressin level was normal. It is possible that a vasopressin-like substance causing SIADH was secreted by either nervous system tissue within an immature teratoma or small cell lung cancer. We should be cautious when SIADH is a complication of an ovarian tumor.

Topics: Adolescent; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Ovarian Neoplasms; Teratoma; Vasopressins

Inappropriate antidiuretic hormone secretion syndrome is rare in patients with gynecologic tumors.. A 22-year-old woman presented with inappropriate antidiuretic hormone secretion symptoms during the 2 months preceding the diagnosis of an immature ovarian teratoma. Vasopressin levels in serum and in the urine were very low. Restriction of water intake and surgical removal of the teratoma resulted in the definitive correction of the hyponatremia. This observation suggests that immature teratoma cells can produce a vasopressin-like factor, and the syndrome may be a sign of an ovarian malignancy.. Pelvic organs should be examined when the more common causes of inappropriate antidiuretic hormone secretion syndrome have been ruled out.

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Drinking; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Ovarian Neoplasms; Teratoma; Vasopressins

Topics: Humans; Male; Mediastinal Neoplasms; Middle Aged; Teratoma; Vasopressins

This is a case report involving a 9 year old girl with a teratoma that infaced mainly the bilateral hypothalamus. The girl was observed for 14 months after partial surgical removal. During that time she showed aphagia, adipsia, hypopituitarism, and visual and psychiatric disturbances. Severe hypernatremia also was present, even though large amounts of 5% glucose solution without salt were given I.V. Food and water were given by nasal gastric gavage and later gavage via gastric fistula, but the hypernatremia remained unchanged. When pitressin or spironolacton (anti-aldosterone) were administered, remarkable effect on the hypernatremia couldn't be found. Upon autopsy it was discovered that the bilateral hypothalamus, left subthalamus and ventral part of the thalamus were invaded by teratoma. Comparing many similar clinical reports and manifestations of hypothalamic lesions in experimental animals, it is reasonable to assume that the mechanisms of hypernatremia were caused by the disturbances of ADH secretion, thirst centre and osmoreceptor in the hypothalamus.

Topics: Aldosterone; Cerebral Ventricle Neoplasms; Child; Female; Humans; Hypernatremia; Hypothalamus; Optic Chiasm; Optic Nerve; Teratoma; Thirst; Vasopressins; Water-Electrolyte Balance

Topics: Adolescent; Aldosterone; Brain Neoplasms; Chlorothiazide; Humans; Hypernatremia; Male; Osmolar Concentration; Pituitary Gland; Prednisone; Renin; Teratoma; Vasopressins; Water-Electrolyte Balance