pituitrin and Stomach-Neoplasms

Topics: Adenocarcinoma; Aged; Female; Hormones, Ectopic; Humans; Inappropriate ADH Syndrome; Stomach Neoplasms; Vasopressins

Topics: Abdomen; Aged; Crohn Disease; Duodenal Diseases; Duodenal Ulcer; Esophageal Achalasia; Esophagitis; Follow-Up Studies; Gastrectomy; Gastritis; Gastrointestinal Hemorrhage; Hematoma; Hernia, Diaphragmatic; Humans; Intestine, Small; Methods; Obesity; Peptic Ulcer Hemorrhage; Postoperative Complications; Stomach Neoplasms; Stomach Ulcer; Vagotomy; Vasopressins; Zollinger-Ellison Syndrome

Although the syndrome of inappropriate antidiuretic hormone has connection with various malignant tumors, there are few reports associated with advanced gastric cancer.. We describe the case of a 63-year-old Korean male with inappropriate antidiuretic hormone syndrome due to an ectopic antidiuretic hormone-producing advanced gastric adenocarcinoma manifested with overt serum hypo-osmolar hyponatremia and high urinary sodium concentrations. His adrenal, thyroidal, and renal functioning were normal, and the hyponatremia improved following removal of the tumor. The cancer cells were immunostained and found to be positive for the antidiuretic hormone. To our knowledge, this is the first report of an antidiuretic hormone-secreting advanced gastric adenocarcinoma associated with the syndrome of inappropriate antidiuretic hormone, showing cancer cells immunostained for the antidiuretic hormone.. Although a strong relationship between gastric cancer and the syndrome of inappropriate antidiuretic hormone remains to be established, we suggest that gastric cancer could be included as a differential diagnosis of cancer that is associated with the syndrome of antidiuretic hormone.

Topics: Adenocarcinoma; Humans; Hyponatremia; Immunohistochemistry; Inappropriate ADH Syndrome; Male; Middle Aged; Paraneoplastic Endocrine Syndromes; Stomach Neoplasms; Tomography, X-Ray Computed; Vasopressins

We describe the treatment of two patients with hemorrhagic shock unresponsive to volume replacement and catecholamines. Both patients responded to a small-dose infusion of vasopressin, which allowed tapering off of the catecholamines. The possible role of small-dose infusions of vasopressin in fluid- and catecholamine-resistant hemorrhagic shock is discussed.

Topics: Blood Loss, Surgical; Blood Volume; Catecholamines; Digestive System Surgical Procedures; Gastrointestinal Neoplasms; Humans; Hypovolemia; Male; Middle Aged; Pancreaticoduodenectomy; Shock, Hemorrhagic; Stomach Neoplasms; Vasoconstrictor Agents; Vasopressins

Topics: Atrial Natriuretic Factor; Endothelins; Esophageal Neoplasms; Gastrectomy; Humans; Peptides; Postoperative Period; Stomach Neoplasms; Vasopressins

A total of 87 surgical cases of gastric carcinoma including 3 carcinoid tumors were investigated with the methods of silver reaction and immunoperoxidase stain for 8 different brain-gut hormones. Argyrophil (AP) cells were demonstrated in 38 cases (44%), argentaffin (AF) cells in 18 (21%) and endocrine cells in 13 (14%). The occurrence of endocrine cells had no relation with histological types. Glicentin cells were demonstrated in 10 cases, somatostatin in 7, motilin in 3, beta-endorphin in 2 and gastrin in one. Endocrine cells appeared generally in small numbers except one carcinoid tumor which had numerous somatostatin cells. No single cell positive for more than two kinds of hormones could be demonstrated. Two undifferentiated carcinomas looking like carcinoid tumors had argyrophil cells and endocrine cells of either somatostatin or beta-endorphin. These results suggest that carcinoid-like carcinoma or endocrine cell carcinoma may lie on the intermediate state between carcinoma and carcinoid tumor.

Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Carcinoid Tumor; Endorphins; Female; Gastrins; Gastrointestinal Hormones; Glucagon; Histocytochemistry; Humans; Male; Microscopy, Electron; Middle Aged; Motilin; Proglucagon; Protein Precursors; Somatostatin; Stomach Neoplasms; Vasoactive Intestinal Peptide; Vasopressins

A four year experience in the management of 585 patients with massive upper gastrointestinal tract bleeding (U. G. I. B.)has been reviewed. The effect of routine fiberoptic gastroscopy, selective angiography, and selective pitressin arterial infusion has been analyzed as it effects the more accurate diagnosis and better non-operative therapy of these dangerously ill patients. Duodenal and gastric ulcer, which comprise one-half of such patients, are best treated by early operation. Mallory-Weiss-syndrome is more frequent than previously appreciated. Pitressin infusion is worthy of trial in diffuse gastritis, varicose- and stress ulcer bleeding. Stress bleeding is usually one manifestation of multiple organ failure due to bacterial sepsis.

Topics: Duodenal Neoplasms; Esophageal and Gastric Varices; Gastrectomy; Gastritis; Gastrointestinal Hemorrhage; Humans; Mallory-Weiss Syndrome; Methods; Peptic Ulcer Hemorrhage; Stomach Neoplasms; Vagotomy; Vasopressins

A single case of gastric plasmacytoma showing unusual clinical and pathological features is described. The patient had gluten sensitive enteropathy, and showed increased circulating IgA levels prior to gastrectomy. Progression of the disease was associated with both K and L light chain proteinuria, hypoalbuminaemia, and vasopressin resistant polyuria. Pathological investigation revealed the coexistence of IgA secreting soft tissue plasmacytoma, with IgG secreting myeloma. The significance of these findings is discussed.

Topics: Autopsy; Blood Transfusion; Celiac Disease; Gastrectomy; Glutens; Humans; Immunoglobulin Fragments; Immunoglobulins; Kanamycin; Lymph Nodes; Male; Middle Aged; Multiple Myeloma; Osmolar Concentration; Plasmacytoma; Polyuria; Proteinuria; Serum Albumin; Sodium; Stomach; Stomach Neoplasms; Vasopressins

Topics: Animals; Dogs; Electrolytes; Hormones, Ectopic; Humans; Hyponatremia; Lung Neoplasms; Lymphoma; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Vasopressins