pituitrin has been researched along with Pruritus* in 2 studies
2 other study(ies) available for pituitrin and Pruritus
| Article | Year |
|---|---|
Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.
From a micromolar high throughput screening hit 7, the successful complementary application of a chemogenomic approach and of a scaffold hopping exercise rapidly led to a low single digit nanomolar human vasopressin 1a (hV1a) receptor antagonist 38. Initial optimization of the mouse V1a activities delivered suitable tool compounds which demonstrated a V1a mediated central in vivo effect. This novel series was further optimized through parallel synthesis with a focus on balancing lipophilicity to achieve robust aqueous solubility while avoiding P-gp mediated efflux. These efforts led to the discovery of the highly potent and selective brain-penetrant hV1a antagonist RO5028442 (8) suitable for human clinical studies in people with autism. Topics: Animals; Antidiuretic Hormone Receptor Antagonists; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autistic Disorder; Brain; Genomics; High-Throughput Screening Assays; Humans; Indoles; Male; Mice; Molecular Structure; Pruritus; Receptors, Vasopressin; Spiro Compounds; Vasoconstrictor Agents; Vasopressins | 2015 |
Synthetic lysine vasopressin in herpetic neuralgia.
Topics: Acute Disease; Adult; Aged; Chronic Disease; Female; Gastrointestinal Motility; Herpes Zoster; Humans; Injections, Intramuscular; Lysine; Male; Middle Aged; Neuralgia; Osteoporosis; Pruritus; Raynaud Disease; Tabes Dorsalis; Time Factors; Trigeminal Neuralgia; Vasopressins | 1973 |