pituitrin and Peripheral-Nervous-System-Diseases

Topics: Abdomen; Autonomic Nervous System; Axons; Constipation; Cranial Nerves; Depression; Diabetic Neuropathies; Drug Interactions; Hallucinations; Humans; Hyponatremia; Hypotension, Orthostatic; Intestinal Obstruction; Muscular Atrophy; Nervous System Diseases; Neural Conduction; Norepinephrine; Pain; Paresthesia; Parkinson Disease; Peripheral Nervous System Diseases; Seizures; Vasopressins; Vincristine

Topics: Achilles Tendon; Animals; Antineoplastic Agents; Autonomic Nervous System; Central Nervous System Diseases; Cranial Nerves; Gastrointestinal Diseases; Hodgkin Disease; Humans; Lymphoma; Motor Activity; Nervous System; Nervous System Diseases; Neurologic Manifestations; Nitrogen Mustard Compounds; Paresthesia; Peripheral Nervous System Diseases; Procarbazine; Reflex, Stretch; Seizures; Vasopressins; Vinblastine; Vincristine

Topics: 5-Hydroxytryptophan; Acanthosis Nigricans; Carcinoid Tumor; Carotid Body Tumor; Catecholamines; Cushing Syndrome; Dermatomyositis; Endocrine System Diseases; Gynecomastia; Hormones, Ectopic; Humans; Hypercalcemia; Hyperthyroidism; Hypoglycemia; Hyponatremia; Neoplasms; Neuromuscular Diseases; Osteoarthropathy, Secondary Hypertrophic; Peripheral Nervous System Diseases; Polycythemia; Puberty, Precocious; Syndrome; Toxins, Biological; Vascular Diseases; Vasopressins; Zollinger-Ellison Syndrome

Topics: Adult; Alopecia; Female; Humans; Infarction; Peripheral Nervous System Diseases; Skin; Vasopressins

Five patients received overdoses of vincristine ranging from 3.5 to 32 mg. Neurotoxicity accounted for most of the complications observed. Peripheral neuropathies, cranial nerve palsies, paralytic ileus, atony of the bladder, hypertension, hypotension, seizures, inappropriate ADH secretion, and severe bone marrow depression were all encountered. Two patients died within 72 hours of the overdose. Another patient died of sepsis 22 days after the overdose. Two patients recovered and were discharged. The three patients who survived longer than a few days showed improvement in the vincristine-induced neuropathy, and the two long-term survivors had essentially complete recovery. It appears that if a patient can be supported through the critical period following an overdose, he can be expected to recover normal neurologic function.

Topics: Adolescent; Autonomic Nervous System; Child; Child, Preschool; Female; Humans; Male; Peripheral Nervous System Diseases; Vasopressins; Vincristine

A patient with acute lymphocytic leukemia is described who developed meningeal leukemia 14 months after the initial diagnosis was made. As part of his antileukemic therapy, at that time, he received prednisone and vincristine, given prophylactically to maintain a bone marrow remission. He inadvertently received 15 mg of vincristine instead of 1.5 mg. Following this overdosage he developed pancytopaenia, mild neurotoxicity and subsequently a grand mal seizure associated with the delayed onset of hyponatremia. This was presumed to be due to the inappropriate secretion of antidiuretic hormone (ADH) secondary to vincristine toxicity. This responded to fluid restriction and anti-epileptiform therapy.

Topics: Adolescent; Anemia, Aplastic; Epilepsy, Tonic-Clonic; Humans; Hyponatremia; Male; Medication Errors; Peripheral Nervous System Diseases; Vasopressins; Vincristine

Topics: Adolescent; Adult; Arginine; Blood; Carcinoma, Small Cell; Cyclophosphamide; Humans; Leukemia, Lymphoid; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Osmolar Concentration; Peripheral Nervous System Diseases; Prednisone; Radioimmunoassay; Sodium; Urine; Vasopressins; Vincristine

Topics: Adolescent; Adult; Aged; Female; Humans; Hyponatremia; Male; Middle Aged; Peripheral Nervous System Diseases; Polyneuropathies; Polyradiculopathy; Sodium; Vasopressins; Water Intoxication

Topics: Afibrinogenemia; Autonomic Nervous System Diseases; Bone Diseases; Carcinoma, Bronchogenic; Collagen Diseases; Cushing Syndrome; Endocrine System Diseases; Fibrinolysis; Hematologic Diseases; Humans; Hypercalcemia; Lung Neoplasms; Muscular Diseases; Neurologic Manifestations; Osteoarthropathy, Secondary Hypertrophic; Pathology; Peripheral Nervous System Diseases; Spinal Cord; Thrombophlebitis; Vascular Diseases; Vasopressins