pituitrin and Ovarian-Neoplasms

Hyponatremia is often caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Hypersecretion of vasopressin from malignant tumors can be considered a cause of SIADH. Most of these ectopic productions of vasopressin are complications of small cell lung cancer. Cases concomitant with ovarian tumors are very rare, and a specific causative substance from the ovary is often unknown. A 16-year-old woman was diagnosed with an ovarian tumor. She developed hyponatremia that was resistant to medical treatment, but immediately improved after surgical resection of the tumor. Her diagnosis was SIADH caused by an ovarian tumor; however, her serum vasopressin level was normal. It is possible that a vasopressin-like substance causing SIADH was secreted by either nervous system tissue within an immature teratoma or small cell lung cancer. We should be cautious when SIADH is a complication of an ovarian tumor.

Topics: Adolescent; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Ovarian Neoplasms; Teratoma; Vasopressins

A patient with a giant ovarian tumor weighing about 7 kg was successfully removed by operation. However, her ECG demonstrated ischemic changes after the operation. We report a case of ischemic heart disease due to persistent diuresis after giant ovarian tumor resection. A 75-year-old, 56.5 kg, 143.5 cm woman was admitted to our hospital for ovarian tumor resection. The preoperative ECG showed normal sinus rhythm and no ischemic changes. Both general anesthesia and epidural anesthesia were planed. An epidural catheter was inserted at T12-L1. Anesthesia was induced with propofol 100 mg, fentanyl 100 microg and vecuronium 8 mg under 100% oxygen inhalation. General anesthesia was maintained with sevoflurane while epidural anesthesia was achieved using 0.375% ropivacaine 6 ml. During the operation, blood pressure was 90-110/70-80 mmHg, with SaO2, 100% and heart rate, 70-80 beats x min(-1). The content of tumor was suctioned for 30 minutes. Surgery was successfully finished without any other incidence. After extubation, her ECG changed to atrial fibrillation from normal sinus rhythm and showed ST-T depression. And then her systolic blood pressure became 80 mmHg or below, but we found continued diuresis at about 10 ml x kg(-1) x hr(-1) for over 2 hr. The total of 7 unit vasopressin was intermittently given for vasoconstriction and antidiuresis. Her hemodynamic was immediately restored, and ECG turned to normal ST-T. The patient had uneventful postoperative recovery.

Topics: Aged; Anesthesia, Epidural; Anesthesia, General; Antidiuretic Agents; Atrial Fibrillation; Diuresis; Electrocardiography; Female; Humans; Myocardial Ischemia; Ovarian Neoplasms; Postoperative Complications; Treatment Outcome; Urination Disorders; Vasopressins

Inappropriate antidiuretic hormone secretion syndrome is rare in patients with gynecologic tumors.. A 22-year-old woman presented with inappropriate antidiuretic hormone secretion symptoms during the 2 months preceding the diagnosis of an immature ovarian teratoma. Vasopressin levels in serum and in the urine were very low. Restriction of water intake and surgical removal of the teratoma resulted in the definitive correction of the hyponatremia. This observation suggests that immature teratoma cells can produce a vasopressin-like factor, and the syndrome may be a sign of an ovarian malignancy.. Pelvic organs should be examined when the more common causes of inappropriate antidiuretic hormone secretion syndrome have been ruled out.

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Drinking; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Ovarian Neoplasms; Teratoma; Vasopressins

Although Cushing's syndrome arises from various neuroendocrine tumors secreting adrenocorticotropin (ACTH) ectopically, ovarian carcinoma rarely causes this syndrome.. A 66-year-old woman presented with facial swelling and skin pigmentation. She manifested hypercortisolemia, high plasma ACTH, and lack of dexamethasone suppression. MRI showed a solid ovarian tumor and resection of the tumor led to normalization of ACTH and cortisol levels. In addition, elevated serum vasopressin (ADH) and alpha-fetoprotein (AFP) were found, which were also normalized after removal of tumors. Pathological diagnosis was serous adenocarcinoma with neuroendocrine and hepatoid features. Immunohistochemistry detected immunoreactivity of chromogranin A, ACTH, ADH, and AFP in tumor cells.. This is a very rare case of successful treatment of Cushing's syndrome arising from an ovarian adenocarcinoma secreting multiple endocrine substances.

Topics: Adrenocorticotropic Hormone; Aged; alpha-Fetoproteins; Cushing Syndrome; Cystadenocarcinoma, Serous; Dehydroepiandrosterone Sulfate; Estradiol; Female; Humans; Immunohistochemistry; Neurophysins; Ovarian Neoplasms; Parathyroid Hormone; Protein Precursors; Vasopressins

A 58-year-old postmenopausal woman with primary ovarian serous carcinoma presented with the syndrome of inappropriate antidiuresis (SIAD). Preoperative workup showed serum sodium level of 110 mEq/liter and antidiuretic hormone level of 3.3 pg/ml. The serum and urine osmolarity were 239 and 371, respectively. Antidiuretic hormone was demonstrated in tumor cells by immunohistochemistry. To the best of the authors' knowledge, this represents the first case of SIAD due to primary ovarian tumor.

Topics: Adenocarcinoma; Female; Humans; Immunohistochemistry; Inappropriate ADH Syndrome; Middle Aged; Osmolar Concentration; Ovarian Neoplasms; Sodium; Vasopressins

Analogues of the neurotransmitter substance P (SP) can interact with neuropeptide receptors, and are reported to inhibit growth of small cell lung cancer cell lines (SCLC CLs). We found [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P (D-Phe5SP) significantly inhibited DNA synthesis by 10/10 human tumour CLs; six SCLC, one N-SCLC (squamous), two ovarian and one squamous cervical carcinoma, with inhibition to 50% control levels (IC50) of 20-50 microM. There was dose dependent inhibition of colony forming efficiency (CFE) in 3/3 SCLC and 1/1 N-SCLC CL, IC50s of 0.5-6.5 microM in 5% serum. Exposure of SCLC CL HC12 to 100 microM D-Phe5SP for 1-4 h caused a progressive fall in viable cell number; surviving cells, grown in the absence of peptide, showed a decreased growth rate. During 1 week's exposure of two SCLC CLs to 20 microM D-Ph5SP, growth was slower than control cultures, while 50-100 microM completely inhibited growth. These inhibitory effects were partially reversed by increasing serum concentration from 5 to 20%, but not by SP, vasopressin, bombesin or insulin-like growth factor 1. There was some inhibition of CFE by 3/3 normal human bone marrows, IC50s of 30-80 microM, compared with 8 microM for HC12 in 20% FCS. Therefore D-Phe5SP appears to have more potent antiproliferative effects in tumour cells than normal cells, suggesting a role for this analogue in tumour treatment.

Topics: Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bombesin; Bone Marrow; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Division; Cell Line; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Female; Fibroblasts; Humans; In Vitro Techniques; Insulin-Like Growth Factor I; Lung Neoplasms; Ovarian Neoplasms; Substance P; Time Factors; Vasopressins

The value of the catheter occlusion therapy is analyzed in 92 cases retrospectively, and the indication, and complication risk of these procedures are considered. In the following vessel areas occlusion with different methods have been performed with decreasing frequency; kidneys, pelvis, legs, gastrointestinal tract, external carotid and internal carotid artery. Serious complications have been observed in therapeutic investigations at the head, especially in occlusions of the external carotid artery. In this group embolisation therapy should be performed with strict indication only.

Topics: Adrenal Gland Neoplasms; Cavernous Sinus; Embolization, Therapeutic; Female; Femoral Artery; Gastrointestinal Hemorrhage; Glomus Jugulare Tumor; Humans; Iliac Artery; Kidney Neoplasms; Neoplasm Recurrence, Local; Ovarian Neoplasms; Renal Artery; Vasopressins

Topics: Acne Vulgaris; Adrenal Cortex Hormones; Adrenalectomy; Androgens; Androstanols; Breast Neoplasms; Estrogens; Female; Hirsutism; Hormones; Humans; Hypercalcemia; Hypertension; Hypophysectomy; Male; Nandrolone; Norethindrone; Ovarian Neoplasms; Progesterone; Prostatic Neoplasms; Thyroid Hormones; Thyroid Neoplasms; Urogenital Neoplasms; Uterine Neoplasms; Vasopressins

Topics: Adenoma, Chromophobe; Adrenal Gland Neoplasms; Animals; Diabetes Insipidus; Dog Diseases; Dogs; Female; Hepatitis; Hepatitis, Animal; Hypothalamo-Hypophyseal System; Kidney; Kidney Diseases; Male; Ovarian Neoplasms; Testicular Neoplasms; Vasopressins