pituitrin and Osteoporosis

The aim of the present study was to examine the association of neuro-otological examination, blood test, and scoring questionnaire data with treatment-resistant intractability in idiopathic benign paroxysmal positional vertigo (BPPV) patients.. We experienced 1520 successive vertigo/dizziness patients at the Vertigo/Dizziness Center in Nara Medical University during May 2014 to April 2018. Six hundred and eleven patients were diagnosed as BPPV (611/1520; 40.2%) according to the diagnostic guideline of the International Classification of Vestibular Disorder in 2015. Among BPPV patients, there were 201 intractable patients (201/611; 32.9%), 66 of whom were idiopathic and enrolled to be hospitalized and receive neuro-otological examinations, including the caloric test (C-test), vestibular evoked cervical myogenic potentials (cVEMP), subjective visual vertical (SVV), glycerol test (G-test), electrocochleogram (ECoG), inner ear magnetic resonance imaging (ieMRI), blood tests including anti-diuretic hormone (ADH) and bone alkaline phosphatase (BAP), and self-rating questionnaires of depression score (SDS). Sixty-six patients were diagnosed as horizontal type cupula (hBPPVcu; n=30), horizontal type canal (hBPPVca; n=10), posterior type (n=20), and probable and/or atypical BPPV (n=6). Data are presented as ratios (+) of the number of idiopathic BPPV patients with examination and questionnaire data outside of the normal range.. The ratio (+) data were as follows: C-test=21.2% (14/66), cVEMP=24.2% (16/66), SVV=48.5% (32/66), G-test=18.2% (12/66), ECoG=18.2% (12/66), ieMRI=12.1% (8/66), ADH=9.1% (6/66), BAP=13.6% (9/66), and SDS=37.9% (25/66). Multivariate regression analysis revealed that the periods of persistent vertigo/dizziness were significantly longer in BPPV patients with hBPPVcu, C-test (+), endolymphatic hydrops (+), and BAP (+) compared with those with negative findings.. Although patients with idiopathic BPPV are usually treatable and curable within 1 month, the presence of hBPPVcu, canal paresis, endolymphatic hydrops, and elevated BAP may make the disease intractable, and thus require additional treatments.

Topics: Aged; Alkaline Phosphatase; Audiometry, Evoked Response; Benign Paroxysmal Positional Vertigo; Caloric Tests; Endolymphatic Hydrops; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Neurophysins; Osteoporosis; Paresis; Protein Precursors; Regression Analysis; Semicircular Canals; Vasopressins; Vestibular Evoked Myogenic Potentials

A new hypothesis is presented for the first time to explain the etiology of osteoporosis. Prostaglandins (E2 and F2 alpha) at precise concentrations, have been observed to be involved in bone formation. A close association exists between levels of prostaglandins (E2 and F2 alpha) demonstrated in the neonatal mouse leading to bone formation, with estimated prostaglandins (E2 and F2 alpha) concentrations reported in man. Several hormones (vasopressin, oxytocin, luteinizing hormone, follicle-stimulating hormone, cortisol, estradiol, and testosterone) can indirectly affect prostaglandin formation leading to reduced bone formation. The association between these hormones and prostaglandins (E2 and F2 alpha) explains the physiological mechanism whereby estradiol can be effective for the treatment of osteoporosis. This association also explains the etiology of lumbar spondylitis/spondylodynia, reasons for complaints of increased pain in wet cold weather among arthritics and a multitude of other events. Mechanisms related to this interaction between various hormones and the effect of prostaglandins (E2 and F2 alpha) on bone formation are discussed.

Topics: Animals; Bone and Bones; Bone Development; Bone Resorption; Calcitonin; Cholecalciferol; Cortisone; Dinoprost; Dinoprostone; Female; Humans; Menopause; Models, Biological; Osteoporosis; Oxytocin; Parathyroid Hormone; Vasopressins

Topics: Adrenal Cortex; Adrenal Medulla; Amenorrhea; Blood-Brain Barrier; Endocrine Glands; Female; Gonadotropins; Growth Hormone; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Menopause; Nicotine; Osteoporosis; Prolactin; Thyrotropin; Vasopressins

Topics: Acute Disease; Adult; Aged; Chronic Disease; Female; Gastrointestinal Motility; Herpes Zoster; Humans; Injections, Intramuscular; Lysine; Male; Middle Aged; Neuralgia; Osteoporosis; Pruritus; Raynaud Disease; Tabes Dorsalis; Time Factors; Trigeminal Neuralgia; Vasopressins

Topics: Aged; Bone and Bones; Calcitonin; Diphosphates; Endocrine System Diseases; Glycosaminoglycans; Gonadal Steroid Hormones; Growth Hormone; Hormones; Humans; Hydroxyproline; Osteoporosis; Parathyroid Hormone; Thyroid Hormones; Vasopressins

Topics: Acromegaly; Adenoma, Chromophobe; Craniopharyngioma; Female; Headache; Humans; Hypogonadism; Insulin; Iodine Radioisotopes; Male; Metyrapone; Optic Atrophy; Osteoporosis; Pituitary Neoplasms; Pituitary-Adrenal Function Tests; Skull Neoplasms; Thyroid Function Tests; Vasopressins; Vision Disorders