pituitrin and Neoplasm-Metastasis

Topics: Adrenocorticotropic Hormone; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Bronchogenic; Enzymes; Humans; Hypercalcemia; Lung Neoplasms; Neoplasm Metastasis; Placental Hormones; Vasopressins

Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Adult; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Chorionic Gonadotropin; Cushing Syndrome; Dexamethasone; Gynecomastia; Humans; Hypercalcemia; Lomustine; Lung Neoplasms; Male; Mechlorethamine; Neoplasm Metastasis; Neostigmine; Parathyroid Hormone; Smoking; Vasopressins; Water-Electrolyte Balance

Topics: Adrenocorticotropic Hormone; Bronchial Neoplasms; Calcitonin; Carcinoma, Small Cell; Erythropoietin; Fluorescent Antibody Technique; Gastrointestinal Hormones; Gonadotropins, Pituitary; Growth Hormone; Histocytochemistry; Hormones, Ectopic; Humans; Hypercalcemia; Insulin; Insulin Secretion; Neoplasm Metastasis; Neurophysins; Oxytocin; Paraneoplastic Endocrine Syndromes; Parathyroid Hormone; Placental Lactogen; Prolactin; Thyrotropin; Vasopressins

Topics: Carcinoma, Bronchogenic; Cell Differentiation; Genes; Hormones, Ectopic; Humans; Liver Neoplasms; Lung Neoplasms; Microscopy, Electron; Mutation; Neoplasm Metastasis; Neoplasms; Paraneoplastic Endocrine Syndromes; Prognosis; Vasopressins

Alcohol intake is a well-known lifestyle risk factor for CRC, and an increasing number of studies have revealed that alcohol intake is also tightly associated with CRC metastasis. However, the effect of alcohol on CRC metastasis and its underlying mechanism remain unclear.. A retrospective cohort study was performed to investigate the characteristics of patients with alcohol-related CRC. The effects of ethanol on the biological behaviours of CRC cells were assessed through in vivo and in vitro assays using the Lieber-DeCarli ethanol liquid diet and ethanol, respectively. The ethanol-mediated signalling pathway and downstream factors were screened through ELISA, western blot, immunofluorescence and co-immunoprecipitation.. Most patients with alcohol-related CRC, particularly those with tumour metastasis, were characterized by a notably higher circulating ethanol level and a lower systemic acetaldehyde level. Moreover, CRC cells accumulated in ethanol, but not acetaldehyde, to notably higher levels compared with adjacent normal cells. Alcohol intake significantly promoted CRC metastasis via the ethanol-mediated TGF-β/Smad/Snail axis, and ethanol induced the cytoplasmic mislocalization of RUNX3 and further promoted the aggressiveness of CRC by targeting Snail. Pirfenidone (PFD) significantly eliminated the effects of ethanol on CRC metastasis by specifically blocking TGF-β signalling.. Alcohol intake plays a vital role in CRC metastasis via the ethanol-mediated TGF-β/RUNX3/Snail axis, and PFD might be a novel therapeutic management strategy for CRC.

Topics: Alcohol Drinking; Animals; Biomarkers; Cell Line, Tumor; Colorectal Neoplasms; Core Binding Factor Alpha 3 Subunit; Disease Models, Animal; Epithelial-Mesenchymal Transition; Humans; Incidence; Mice; Neoplasm Metastasis; Neurophysins; Protein Binding; Protein Precursors; Protein Transport; Signal Transduction; Snail Family Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vasopressins; Xenograft Model Antitumor Assays

Vasoactive drugs have a variety of effects upon splanchnic and hepatic haemodynamics which may alter tumour blood flow and potentiate the delivery of a chemotherapeutic drug to hepatic tumour. We have investigated the effects of vasopressin infusion on hepatic tumour blood flow in an experimental model of liver tumour. Hepatic tumour was induced by the intraportal inoculation of HSN sarcoma cells. Hepatic and splanchnic blood flow was determined using a dual reference microsphere technique before and after an intravenous infusion of vasopressin at a dose of 0.1 mU kg-1 min-1 for 10 min. There was a significant increase in systemic arterial blood pressure associated with a rise in portal venous inflow (P less than 0.01, Wilcoxen Signed rank Test) and a significant fall in hepatic arterial flow (P less than 0.05). The tumour: liver blood flow ratio was significantly increased by vasopressin infusion (P less than 0.02). Vasopressin infusion decreases hepatic arterial flow and increases tumour blood flow which may potentiate the delivery of a regionally delivered chemotherapeutic drug to hepatic tumour.

Topics: Animals; Hemodynamics; Hepatic Artery; Liver Neoplasms, Experimental; Neoplasm Metastasis; Rats; Regional Blood Flow; Vasopressins

The relationships between prognostic factors and duration of survival in small cell lung cancer were investigated in a consecutive series of 874 patients treated with combination chemotherapy with or without irradiation. The series included 443 patients with limited and 431 patients with extensive stage disease based on staging including bone marrow examination and peritoneoscopy with liver biopsy but no routine scans. The median durations of survival for the two disease categories were 48 and 30 weeks, respectively. The influence on survival of various pretreatment factors was investigated by use of univariate methods and Cox's multivariate regression model. Patients in each stage were treated according to one of three controlled trials. Variations among the applied treatment regimens did not result in significant differences in duration of survival among patients with limited disease. An alternating regimen was superior to continuous therapy in patients with extensive disease and raised serum lactate dehydrogenase. Prognosis was correlated with disease extent. Surgical resection as well as limited stage disease thus both contributed to survival. Poor performance status, reduced hemoglobin concentration, and raised values for serum lactate dehydrogenase were significantly associated with a reduced duration of survival in both stages. Females with limited disease lived significantly longer than males while advanced age was a negative prognostic factor in extensive disease. Plasma sodium and serum urate were both predictive of survival in limited disease. Proved metastatic disease affecting specific sites or total number of metastatic sites did not carry significant prognostic information in a model including a general variable characterizing stage of disease. Fifty of the 778 patients, on whom the multiple regression model was based, were alive and disease free 2 years after the start of the treatment. Two-year survival rates were strongly correlated to groupings based on prognostic factors, and information about disease extent was not mandatory for predicting the probability of long term disease-free survival.

Topics: Adult; Aged; Alkaline Phosphatase; Carcinoma, Small Cell; Combined Modality Therapy; Erythropoietin; Female; Hormones, Ectopic; Humans; L-Lactate Dehydrogenase; Lung Neoplasms; Male; Middle Aged; Models, Biological; Neoplasm Metastasis; Prognosis; Regression Analysis; Risk; Vasopressins

Review of clinical data from 350 patients with small-cell lung cancer (SCLC) revealed hyponatremia (sodium less than 130 mEq/L) attributable to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in 40 patients (11%). Although hyponatremia was severe in most instances (median, sodium 117 mEq/L), symptoms attributable to water intoxication were identified in only 27% of hyponatremic episodes. Development of SIADH showed no correlation with clinical stage, distribution of metastatic sites, sex, or histologic subtype of small-cell carcinoma. SIADH occurred most often with initial presentation (33 of 40), and resolved promptly (less than 3 weeks) with initiation of combination chemotherapy in 80% of evaluable patients. The presence of SIADH did not influence response to chemotherapy or overall survival as an independent variable. However, in five patients profound hyponatremia developed immediately following primary cytotoxic therapy (range, one to five days). Despite initial control of SIADH, dilutional hyponatremia recurred in 70% of patients with tumor progression. Our findings suggest that development of clinically demonstrable SIADH in patients with SCLC is dependent on functional properties of the neoplastic cells, rather than tumor burden or metastatic site. The potential for development of clinically significant hyponatremia early in the course of cytotoxic therapy emphasizes the need to closely monitor patients, particularly those receiving chemotherapy regimens requiring substantial intravenous hydration.

Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Female; Inappropriate ADH Syndrome; Lung Neoplasms; Male; Neoplasm Metastasis; Neoplasm Staging; Osmolar Concentration; Paraneoplastic Endocrine Syndromes; Sodium; Vasopressins

Vasopressin (ADH) was measured in CSF and plasma in 75 evaluable patients with known or suspected CNS metastases from small-cell bronchogenic carcinoma (SCBC), and in 66 control patients having neither malignant disease nor organic CNS disease. The presence of CNS metastases was confirmed or excluded on the basis of computed tomographic scans, neurologic examination, and autopsy. Twenty-four of the 75 patients had no CNS metastases. Ten of the 51 patients with CNS metastases had leptomeningeal carcinomatosis (MC). CSF-ADH was significantly increased in patients with MC (P less than .05), but not in patients having exclusively parenchymatous CNS metastases. Taking 2 pg/mL (95th percentile of control patients) as the upper limit of normal, 15 SCBC patients had elevated CSF-ADH, including 12 patients with CNS metastases and six patients with MC. The CSF-ADH to plasma ADH ratio was significantly increased in patients with CNS metastases (P less than .05). Patients without CNS metastases had a ratio less than or equal to 0.8 whereas the ratio was greater than 0.8, in 21 of the 51 patients with CNS metastases. The positive and negative predictive values with 95% confidence limits were 84% to 100% and 31% to 59%, respectively. Patients with inappropriate secretion of ADH (SIADH) constituted a significantly greater proportion of patients with elevated CSF-ADH than of patients with normal CSF-ADH levels (P less than .05). In addition, patients with SIADH constituted a significantly greater proportion of patients with MC than of patients with parenchymatous metastases (P less than .05). The diagnostic application of these findings is limited because of the large number of false-negative results, but it may prove to be of value in conjunction with the measurement of other tumor markers.

Topics: Carcinoma, Bronchogenic; Carcinoma, Small Cell; Central Nervous System Diseases; Humans; Inappropriate ADH Syndrome; Intracranial Pressure; Lung Neoplasms; Meningeal Neoplasms; Neoplasm Metastasis; Vasopressins

An autopsy case of a 67-year-old Japanese male is presented. He had been suffering from carcinoid syndrome for 5 years and showed a typical picture of carcinoid heart disease. In Japan, carcinoid heart disease is rare and we can find only four reported cases (33% of reported carcinoid syndrome). The patient had high urinary secretion of 5-HIAA and high serum serotonin, and finally he died of heart failure and bronchopneumonia. The primary site of this carcinoid tumor was of the bronchus of the right B10c , and it had large hepatic metastases. Electronmicroscopically, the tumor cells had secretory granules measuring 1500-3500 A in diameter. Immunohistochemically, the tumor cells were markedly positive for human chorionic gonadotropin (hCG) and antidiuretic hormone (ADH) and positive for serotonin, in both the primary site and hepatic metastases. Characteristic fibrous plaques were detected in the right atrium, tricuspid valve, right ventricle, and left atrium. Electron-microscopically, the fibrous plaques consisted of smooth muscle cells and myofibroblasts surrounded by basement membrane-like material. The abundant matrix of the fibrous plaques contained acid mucopolysaccharide, microfibrils and collagen fibers. The same fibrous plaques were also found in hepatic veins. Furthermore, retroperitoneal fibrosis was present, which showed proliferation of myofibroblasts, fibroblasts and immature mesenchymal cells.

Topics: Aged; Bronchi; Bronchial Neoplasms; Carcinoid Heart Disease; Carcinoid Tumor; Chorionic Gonadotropin; Humans; Male; Malignant Carcinoid Syndrome; Microscopy, Electron; Myocardium; Neoplasm Metastasis; Retroperitoneal Fibrosis; Serotonin; Vasopressins

Diabetes insipidus, resulting from metastatic involvement of the neurohypophysial system, is a rare complication of breast cancer. This review examined the clinical features, metastatic pattern, and radiological and postmortem findings of 39 breast cancer patients with this complication. All patients had polyuria and polydipsia, and all had evidence of advanced metastatic breast cancer. A high incidence of meningeal carcinoma carcinomatosis and/or sellar metastases was observed. In view of the anatomical proximity of the posterior pituitary to the dura mater and the sella turcica, our findings suggest that metastases to the neurohypophysis can occur not only as a result of hematogenous dissemination of malignant cells, but also from direct tumor extension and/or invasion from adjacent structures. Although satisfactory symptomatic relief can be obtained with vasopressin tannate, complete resolution of the diabetic insipidus syndrome was evident only in those patients who had achieved control of the underlying breast disease.

Topics: Adult; Aged; Breast Neoplasms; Diabetes Insipidus; Female; Humans; Meningeal Neoplasms; Menopause; Middle Aged; Neoplasm Metastasis; Pituitary Neoplasms; Sella Turcica; Vasopressins

Immunoactive antidiuretic hormone (ADH) was measured by radioimmunoassay in the plasma, lung tumours and metastatic tumours of nineteen patients with bronchogenic carcinoma. Ten patients had hyponatraemia and carcinoma of the small oat cell type. Plasma ADH measured in nine of these patients ranged from 11--270 pg/ml and was elevated above the normal range (4.6--6.2 pg/ml) in all subjects. ADH-immunoreactive material was detectable in all primary lung tumours (range 9--1080 pg/mg wet weight, n = 7) and metastases (range 5--63 pg/mg wet weight, n = 9) obtained from the hyponatraemic patients. A statistical relationship existed between plasma and tumour ADH concentration in six patients where both measurements were performed. Three patients had small cell carcinomas (two oat cell and one anaplastic) without overt hyponatraemia. ADH-like material was detectable in the lung tumours (18 and 1.1 pg/mg wet weight) and liver metastases (4 and 1.0 pg/mg wet weight) of two patients but not in the third. Four of the remaining patients had squamous cell carcinomas and two had adenocarcinomas. None had hyponatraemia. ADH-like material was undetectable in all lung tumours, metastatic tumours and uninvolved tissue from these patients. ADH extracted from the pituitaries of four patients ranged from 6400--13200 pg/mg wet weight. ADH immunoreactive extracts of six lung tumours and nine metastases (all oat cell) showed the same pattern on elution from a Sephadex G-25 column. A large peak, which made up 65% of the total activity, was eluted in the same position as synthetic arginine vasopressin and contained comparable amounts of immunoreactive and bioactive ADH. Two smaller peaks (8 and 27% of total activity) were eluted in positions of higher molecular weight and contained more immunoreactive than bioactive ADH. In contrast, three of four pituitary extracts showed only a single peak which eluted in the same position as marker vasopressin.

Topics: Carcinoma, Bronchogenic; Carcinoma, Small Cell; Chromatography, Affinity; Chromatography, Gel; Female; Humans; Lung Neoplasms; Male; Neoplasm Metastasis; Sodium; Vasopressins

A case report is presented in which myxedema coma and inappropriate antidiuretic hormone secretion developed as a result of radiation therapy and surgery to the neck area in a patient with recurrent metastatic squamous cell carcinoma of the floor of the mouth. Laboratory findings of low thyroxine level and the findings of persistent hyponatremia and hypoosmolality of serum in spite of persistent sodium loss in the urine were helpful in diagnosing the problem. Treatment included thyroid hormone replacement and fluid restriction resulting in complete reversal of her condition. We believe that patients with head and neck cancer who have undergone a course of radiation to the neck, and particularly when thyroid function might have been altered by previous subtotal thyroidectomy as part of a curative resection, should be carefully followed with periodic thyroid function assays and serum electrolytes with particular attention to serum sodium values.

Topics: Carcinoma, Squamous Cell; Coma; Female; Head and Neck Neoplasms; Humans; Hyponatremia; Hypothyroidism; Middle Aged; Myxedema; Neoplasm Metastasis; Radiation Injuries; Vasopressins

A 61 year old woman presented with profound hyponatremia and markedly low serum osmolality. Urine osmolality was greater than the serum osmolality, an abnormality that was corrected by water restriction, suggesting inappropriate ADH secretion. Although there were no physical signs of Cushing's syndrome, her serum potassium level was low and markedly elevated levels of plasma and urine corticosteroids were not altered by the administration of large amounts of dexamethasone, suggesting the ectopic ACTH-MSH syndrome. Plasma levels of immunoreactive ACTH and beta-MSH were elevated. At autopsy, a metastastic oat cell carcinoma of the lung, not detected antemortem by chest roentgenograms and bronchoscopy, was found. Immunoreactive ADH, ACTH and beta-MSH were detected in the primary tumor and in metastases to the liver. beta-MSH was also detected in the spleen, in which metastases were observed. This is the first documented case of the simultaneous production of ADH, ACTH and beta-MSH by neoplastic tissue associated with clinical manifestations of the syndrome of inappropriate ADH secretion and the ectopic ACTH-MSH syndrome.

Topics: Adrenocorticotropic Hormone; Carcinoma, Small Cell; Female; Humans; Liver Neoplasms; Lung Neoplasms; Melanocyte-Stimulating Hormones; Middle Aged; Neoplasm Metastasis; Splenic Neoplasms; Vasopressins

Topics: Drug Therapy, Combination; Humans; Neoplasm Metastasis; Neoplasms; Syndrome; Vasopressins; Vinblastine

Lithium carbonate, useful in the treatment of manic-depressive disorders, can produce nephrogenic diabetes insipidus. The drug, therefore, has been used to facilitate renal waster excretion when severe hyponatremia occurs in the syndrome of inappropriate antidiuretic hormone secretion. Symptomatic dilutional hyponatremia developed in a patient with pulmonary carcinoma whom we treated. Lithium carbonate was administered and renal sodium wasting, hypovolemia, and hypotension occurred. Hyperkalemia was also observed, and since adrenal steroid levels were not decreased, impairment of distal tubular function was suggested. Lithium carbonate blocks antidiuretic hormone effect by decreasing collecting duct cyclic adenosine monophosphate generation. These observations suggest that more generalized inhibitory effects on renal tubular function may also result from its use. An alternative drug, demeclocycline, may be preferable.

Topics: Carcinoma, Squamous Cell; Humans; Hyponatremia; Lithium; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Potassium; Sodium; Vasopressins

The syndrome of inappropriate secretion of antidiuretic hormone was recognized in a sixty-year-old man with a poorly differentiated metastatic adenocarcinoma of the prostate gland. Elevated levels of antidiuretic hormone were found in the patient's serum and in the prostatic tumor but not in the cerebrospinal fluid. The patient's clinical course is detailed, and the pathophysiology of this syndrome is discussed.

Topics: Adenocarcinoma; Humans; Male; Middle Aged; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Prostate; Prostatic Neoplasms; Vasopressins

Topics: Adrenocorticotropic Hormone; Bone Neoplasms; Bronchial Neoplasms; Carcinoma, Small Cell; Corticotropin-Releasing Hormone; Female; Genes, Regulator; Genetic Code; Hormones, Ectopic; Humans; Hypercalcemia; Hyperthyroidism; Male; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Parathyroid Hormone; Thyrotropin; Vasopressins

Topics: Adrenal Gland Neoplasms; Autopsy; Bone Neoplasms; Bronchial Neoplasms; Calcitonin; Carcinoma; Carcinoma, Small Cell; Humans; Hyponatremia; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Metastasis; Osmolar Concentration; Paraneoplastic Endocrine Syndromes; Syndrome; Vasopressins

Topics: Adenocarcinoma; Animals; Carcinoma, Bronchogenic; Choriocarcinoma; Culture Media; Diuresis; Female; In Vitro Techniques; Liver; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Oxytocin; Pancreatic Neoplasms; Pregnancy; Rats; Recurrence; Uterine Neoplasms; Vasopressins

Topics: Adult; Aged; Bone Neoplasms; Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Mathematics; Methylprednisolone; Middle Aged; Models, Biological; Neoplasm Metastasis; Palliative Care; Remission, Spontaneous; Time Factors; Vasopressins

Topics: Autopsy; Brain Neoplasms; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Humans; Hypopituitarism; Hypothalamus; Male; Microscopy, Electron; Middle Aged; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Pituitary Gland; Pituitary Neoplasms; Vasopressins

Topics: Adolescent; Adult; Arginine; Blood; Carcinoma, Small Cell; Cyclophosphamide; Humans; Leukemia, Lymphoid; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Osmolar Concentration; Peripheral Nervous System Diseases; Prednisone; Radioimmunoassay; Sodium; Urine; Vasopressins; Vincristine

Topics: Adrenal Gland Neoplasms; Carcinoma; Female; Humans; Hyponatremia; Middle Aged; Neoplasm Metastasis; Osmolar Concentration; Sodium; Syndrome; Vasopressins

Topics: Adrenocorticotropic Hormone; Biological Assay; Calcitonin; Carcinoma; Depression, Chemical; Dexamethasone; Fluorescent Antibody Technique; Humans; Hydrocortisone; Male; Middle Aged; Neoplasm Metastasis; Parathyroid Hormone; Radioimmunoassay; Secretory Rate; Stimulation, Chemical; Thyroid Neoplasms; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Amino Acids; Animals; Biological Assay; Carcinoma, Bronchogenic; Corticotropin-Releasing Hormone; Dexamethasone; Electrophoresis; Feedback; Hormones, Ectopic; Humans; Lung Neoplasms; Lysine; Metyrapone; Neoplasm Metastasis; Neoplasm Proteins; Pancreatic Neoplasms; Peptides; Rats; Vasopressins

Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenocortical Hyperfunction; Bronchial Neoplasms; Carcinoma, Bronchogenic; Female; Hormones, Ectopic; Humans; Hypercalcemia; Hyponatremia; Neoplasm Metastasis; Vasopressins

Topics: Adrenalectomy; Adrenocorticotropic Hormone; Alkalosis; Autoimmune Diseases; Bone Diseases; Carcinoma, Bronchogenic; Cushing Syndrome; Endocrine System Diseases; Hypercalcemia; Hyperparathyroidism; Hyponatremia; Lung Neoplasms; Metabolic Diseases; Neoplasm Metastasis; Neurologic Manifestations; Neuromuscular Diseases; Skin Diseases; Skin Manifestations; Vascular Diseases; Vasopressins

Topics: Adult; Aged; Breast Neoplasms; Diabetes Insipidus; Female; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Male; Middle Aged; Neoplasm Metastasis; Pancreatic Neoplasms; Pituitary Neoplasms; Polyuria; Vasopressins

Topics: Breast Neoplasms; Carcinoma; Deficiency Diseases; Diabetes Insipidus; Female; Humans; Injections, Subcutaneous; Male; Neoplasm Metastasis; Osmolar Concentration; Pituitary Function Tests; Pituitary Gland, Posterior; Pituitary Neoplasms; Polyuria; Vasopressins; Water Deprivation

Topics: Bronchial Neoplasms; Carcinoma; Electroencephalography; Humans; Hyponatremia; Middle Aged; Natriuresis; Neoplasm Metastasis; Vasopressins; Water Intoxication

Topics: Aged; Blood Urea Nitrogen; Brain Neoplasms; Female; Humans; Hypertonic Solutions; Hyponatremia; Hypothalamus; Lung Neoplasms; Neoplasm Metastasis; Osmolar Concentration; Plasma Volume; Sodium; Vasopressins; Water-Electrolyte Balance

Topics: Adenocarcinoma; Blood Volume; Humans; Hyponatremia; Liver; Male; Middle Aged; Neoplasm Metastasis; Osmolar Concentration; Prostatic Neoplasms; Sodium; Vasopressins

Topics: Brain Neoplasms; Carcinoma, Bronchogenic; Cerebral Cortex; Dementia; Glioma; Humans; Hyponatremia; Liver Neoplasms; Lymph Nodes; Male; Mental Disorders; Middle Aged; Neoplasm Metastasis; Seizures; Sodium; Thalamus; Vasopressins

Topics: 17-Hydroxycorticosteroids; Adenocarcinoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Insufficiency; Aldosterone; Body Weight; Female; Humans; Hyponatremia; Lung Neoplasms; Middle Aged; Neoplasm Metastasis; Sodium; Vasopressins; Water-Electrolyte Balance

Topics: Breast Neoplasms; Cortisone; Desoxycorticosterone; Diabetes Insipidus; Female; Hematocrit; Humans; Hyponatremia; Hypothalamo-Hypophyseal System; Middle Aged; Neoplasm Metastasis; Nerve Degeneration; Nerve Regeneration; Neurons; Pituitary Gland; Pituitary Gland, Posterior; Postoperative Complications; Sodium; Sodium Chloride; Vasopressins; Water; Water-Electrolyte Balance

Topics: Adrenocorticotropic Hormone; Adult; Aged; Astrocytoma; Brain Edema; Brain Neoplasms; Cerebral Angiography; Echoencephalography; Electroencephalography; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pituitary Gland; Radionuclide Imaging; Vasopressins

Topics: Adenocarcinoma; Carcinoma, Bronchogenic; Female; Humans; Iodine Isotopes; Lung Neoplasms; Middle Aged; Neoplasm Metastasis; Vasopressins

Topics: Adult; Atropine; Carcinoma, Bronchogenic; Ethanol; Glucose; Humans; Male; Neoplasm Metastasis; Vasopressins; Water-Electrolyte Balance

Topics: Brain Neoplasms; Electroencephalography; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Natriuresis; Neoplasm Metastasis; Vasopressins; Water Intoxication

Topics: Adenocarcinoma; Animals; Biological Assay; Carcinoma, Bronchogenic; Chickens; Humans; Hyponatremia; Lung Neoplasms; Male; Methods; Middle Aged; Neoplasm Metastasis; Neoplasms, Multiple Primary; Osmolar Concentration; Oxytocin; Pancreatic Neoplasms; Pneumonectomy; Rabbits; Radioimmunoassay; Rats; Vasopressins

Topics: Animals; Anura; Biological Assay; Carcinoma, Bronchogenic; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Diuresis; Hormones, Ectopic; Humans; Hyponatremia; Liver Neoplasms; Lymphatic Metastasis; Neoplasm Metastasis; Pancreatic Neoplasms; Thioglycolates; Trypsin; Vasopressins

Topics: Aged; Animals; Anura; Bronchial Neoplasms; Carcinoma; Humans; Hyponatremia; Hypopituitarism; Male; Neoplasm Metastasis; Pancreatic Neoplasms; Permeability; Sodium; Urinary Bladder; Vasopressins; Water

Topics: Adult; Bone Neoplasms; Breast Neoplasms; Diuresis; Female; Humans; Mannitol; Neoplasm Metastasis; Neoplasm Recurrence, Local; Vasopressins; Water

Topics: Bone Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous Cell; Diuresis; Humans; Hypercalcemia; Male; Middle Aged; Neoplasm Metastasis; Vasopressins

Topics: Breast Neoplasms; Diuresis; Female; Humans; Hypophysectomy; Hypothalamus; Neoplasm Metastasis; Palliative Care; Vasopressins

Topics: Adrenal Gland Neoplasms; Cyclophosphamide; Humans; Male; Middle Aged; Neoplasm Metastasis; Vasopressins

Topics: Biological Assay; Blood; Carcinoma; Carcinoma, Bronchogenic; Humans; Liver Neoplasms; Neoplasm Metastasis; Vasopressins

Topics: Autonomic Nerve Block; Carcinoma; Chlorpromazine; Geriatrics; Histocytochemistry; Humans; Kidney Diseases; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Nitrogen Mustard Compounds; Vasopressins

Topics: Aldosterone; Brain Neoplasms; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lung Neoplasms; Natriuresis; Neoplasm Metastasis; Physiology; Vasopressins