pituitrin and Myoma

To explore the safe and effective method of hemostasis in laparoscopic hysteromyomectomy (LM).. Two hundred and eighty women with symptomatic uterine intramural fibroids undergoing LM were assigned to 4 groups, Group A undergoing fibroid pedicle ligation, Group B injected with 12 IU diluted vasopressin around the myoma, Group C injected with 20 IU oxytocin combined with pedicle ligation, and Group D injected with vasopressin combined with pedicle ligation. The operation time, amount of blood loss, operative complications, bowel deflation, post-operative hemoglobin dropping, and length of hospital stay were compared.. The amounts of blood loss of Groups A and C were (171 +/- 146) ml and (184 +/- 140) ml, both significantly higher than those of Groups B and D [(115 +/- 70) ml and (106 +/- 73) ml, both P < 0.01]. The length of hospital stay of Group D was (2.9 +/- 0.5) d, significantly shorter than those of Groups A, B, and C [(3.1 +/- 0.7) d, (3.6 +/- 0.8) d, and (3.3 +/- 0.7) d, all P < 0.05]. The bowel deflation time of Group D was (20 +/- 6) h, significantly shorter than those of the Groups A, B, and C [(26 +/-) h, (25 +/- 7) h, and (25 +/- 8) h respectively, all P < 0.05]. The post-operative hemoglobin dropping of group D was (1.1 +/- 0.9) g/L, significantly less than those of Groups A, B, and C [(1.5 +/- 1.0), (1.4 +/- 0.8), and (1.2 +/- 0.7) g/L respectively, all P < 0.05].. Vasopressin (12 IU) injection around the myoma is a simple, effective, and safe homeostatic procedure during LM. Pedicle ligation can reduce advanced post-operative bleeding post-operation.

Topics: Adult; Combined Modality Therapy; Female; Gynecologic Surgical Procedures; Hemostatic Techniques; Hemostatics; Humans; Laparoscopy; Leiomyoma; Myoma; Oxytocics; Oxytocin; Postoperative Hemorrhage; Treatment Outcome; Uterine Neoplasms; Vasopressins

Topics: Adult; Endometrial Ablation Techniques; Female; Humans; Leiomyoma; Middle Aged; Myoma; Uterine Neoplasms; Vasopressins

In 17 women with refractory bleeding after myoma resection a dilute vasopressin pack was applied. Twenty units of vasopressin was diluted with 30 ml normal saline solution. A 1-inch new gauze pack was soaked in the dilute vasopressin and packed into the uteri of patients with bleeding from the beds of resected submucous myomas. The pack was left in place for no more than an hour. In none of the cases was there bleeding after the removal of the pack nor were there any side effects that could be attributed to the vasopressin.

Topics: Administration, Intravaginal; Adult; Female; Hemorrhage; Humans; Hysteroscopy; Middle Aged; Myoma; Postoperative Complications; Vasopressins