pituitrin and Myocarditis

A number of vasoactive mediators have been identified in plasma and in the heart. Some of them may be liberated in inflammatory heart disease. The action of mediators on coronary vasculature in various animal models and their potential role in inflammatory heart disease is reviewed. Their role in patients remains to be determined.

Topics: Adrenal Glands; Animals; Atrial Natriuretic Factor; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels; Eicosanoids; Endothelium, Vascular; Humans; Myocarditis; Neuropeptides; Renin-Angiotensin System; Sympathetic Nervous System; Vasopressins

Pediatric heart failure (HF) is an important cause of morbidity and mortality in childhood. This article presents guidelines for the recognition, diagnosis, and early medical management of HF in infancy, childhood, and adolescence. The guidelines are intended to assist practitioners in office-based or emergency room practice, who encounter children with undiagnosed heart disease and symptoms of possible HF, rather than those who have already received surgical palliation. The guidelines have been developed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, and are accompanied by practical Recommendations for their application in the clinical setting, supplemented by online material. This work does not include Recommendations for advanced management involving ventricular assist devices, or other device therapies.

Topics: Adolescent; Algorithms; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Arrhythmogenic Right Ventricular Dysplasia; Biomarkers; Canada; Cardiomyopathies; Cardiotonic Agents; Catecholamines; Child; Child, Preschool; Combined Modality Therapy; Death, Sudden, Cardiac; Diagnosis, Differential; Diuretics; Echocardiography; Electrocardiography, Ambulatory; Evidence-Based Medicine; Heart Defects, Congenital; Heart Failure; Humans; Infant; Magnetic Resonance Imaging; Myocarditis; Myocardium; Prognosis; Risk Factors; Societies, Medical; Vasodilator Agents; Vasopressins

Topics: Arteriosclerosis; Diabetes Insipidus; Diuresis; Glucose; Heart Failure; Humans; Hypernatremia; Hyponatremia; Injections, Intravenous; Isotonic Solutions; Mannitol; Myocarditis; Osmosis; Potassium; Urine; Vasopressins; Water-Electrolyte Balance