pituitrin and Muscular-Atrophy

Topics: Abdomen; Autonomic Nervous System; Axons; Constipation; Cranial Nerves; Depression; Diabetic Neuropathies; Drug Interactions; Hallucinations; Humans; Hyponatremia; Hypotension, Orthostatic; Intestinal Obstruction; Muscular Atrophy; Nervous System Diseases; Neural Conduction; Norepinephrine; Pain; Paresthesia; Parkinson Disease; Peripheral Nervous System Diseases; Seizures; Vasopressins; Vincristine

Tail-suspension of rats has been employed for the study of disuse atrophy of hindlimb muscles and bones. From our study, it is suggested that stress exacerbates muscle and bone atrophy; however, the determination of stress hormones has been inappropriately performed. For assessing the effect of tail suspension on stress hormone secretion, suspension was performed for 7 days in a metabolic cage. Urinary excretions of corticosterone, catecholamines and antidiuretic hormone were determined during the 7-day suspension. Urine volume was unchanged during the suspension period, whereas water consumption was decreased during suspension. Urinary excretion of corticosterone and catecholamines increased significantly during the initial 3 days of suspension. The excretion of antidiuretic hormone increased throughout the suspension period. Our results demonstrated that the determination of urinary excretion of these hormones is useful for evaluating the stress reaction.

Topics: Adrenal Glands; Animals; Body Weight; Corticosterone; Epinephrine; Hindlimb Suspension; Male; Muscular Atrophy; Norepinephrine; Organ Size; Rats; Rats, Wistar; Stress, Physiological; Thymus Gland; Urine; Vasopressins

Topics: Adult; Chemical Phenomena; Chemistry; Female; Humans; Hypothalamus; In Vitro Techniques; Ligases; Liver; Muscular Atrophy; Porphyrias; Porphyrins; Vasopressins