pituitrin and Lymphoma

Topics: Achilles Tendon; Animals; Antineoplastic Agents; Autonomic Nervous System; Central Nervous System Diseases; Cranial Nerves; Gastrointestinal Diseases; Hodgkin Disease; Humans; Lymphoma; Motor Activity; Nervous System; Nervous System Diseases; Neurologic Manifestations; Nitrogen Mustard Compounds; Paresthesia; Peripheral Nervous System Diseases; Procarbazine; Reflex, Stretch; Seizures; Vasopressins; Vinblastine; Vincristine

In order to understand the importance of various cis-acting elements in regulating VP gene expression, transgenic mice regulated by VP constructs were produced containing 3.8 kb of the 5' flanking region and all the exons and introns in the mouse VP gene, which was fused at the end of exon 3 to an SV40 T antigen (Tag). In the transgenic mice by the pVPSV.IGR3.6 construct, all the six transgenic mice died at the age of 2-6 weeks. In the transgenic mice by pVPSV.IGR2.1, 21% of them had brain tumors at 5 weeks and 100% of the mice had brain tumors after 24 weeks. Histological analysis of the transgenic mice revealed primitive neuroectodermal tumors (PNET) in the brain and lymphoma in the spleen and lymph nodes. The phenotype differences between the two transgenic mice suggest that tissue-specific expression might be regulated by cis-acting elements in the 1.5-kb of the 3(') flanking region, which are not contained in pVPSV.IGR2.1. In conclusion, pVPSV.IGR2.1 mice will be a valuable mouse model system for investigating PNET tumorigenesis in the brain and lymphoma in the lymph nodes and spleen.

Topics: Animals; Antigens, Polyomavirus Transforming; Brain Neoplasms; Humans; Lymph Nodes; Lymphoma; Mice; Mice, Transgenic; Recombinant Fusion Proteins; Spleen; Tissue Distribution; Transgenes; Vasopressins

We report three lymphoma patients in whom the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) was observed during the course of lymphoma-associated hemophagocytic syndrome (LAHS). The clinical course was devoid of any known mechanism for SIADH which could be attributable to lymphoma or antineoplastic treatment. Alternatively, high serum levels of interleukin-1 beta and tumor necrosis factor-alpha, which stimulate the secretion of antidiuretic hormone, may have contributed to the development of SIADH in our patients, who were receiving glucocorticoids. In conclusion, LAHS patients should be considered to be at high risk for SIADH.

Topics: Aged; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Inappropriate ADH Syndrome; Interleukin-1; Lymphoma; Lymphoma, T-Cell; Male; Middle Aged; Nose Neoplasms; Risk Factors; Sodium; Tumor Necrosis Factor-alpha; Vasopressins

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Cerebellar Neoplasms; Combined Modality Therapy; Cyclophosphamide; Deamino Arginine Vasopressin; Dexamethasone; Diabetes Insipidus; Doxorubicin; Humans; Hydrocortisone; Lymphoma; Magnetic Resonance Imaging; Male; Thyroxine; Vasopressins; Ventriculoperitoneal Shunt; Vincristine

Topics: Adult; Dexamethasone; Diabetes Insipidus; Humans; Lymphoma; Male; Osmotic Pressure; Vasopressins

Topics: Animals; Dogs; Electrolytes; Hormones, Ectopic; Humans; Hyponatremia; Lung Neoplasms; Lymphoma; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Vasopressins