pituitrin and Lead-Poisoning

A five-year-old girl with known sickle cell disease presented with severe hyponatremia and findings compatible with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). She was found to have lead levels in the Class III category. By exclusion, we postulated that the SIADH was in some way related to the high lead levels, since this was the only abnormality the patient exhibited. The toxic lead levels and the elevated vasopressin levels rapidly responded to dimercaprol and calcium EDTA chelation therapy.

Topics: Anemia, Sickle Cell; Chelation Therapy; Child, Preschool; Dimercaprol; Edetic Acid; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lead; Lead Poisoning; Vasopressins

Topics: Aldosterone; Angiotensin II; Animals; Kidney; Lead Poisoning; Male; Potassium; Rats; Sodium; Sodium-Potassium-Exchanging ATPase; Time Factors; Vasopressins

Topics: Enzyme Induction; Growth Hormone; Humans; Hydro-Lyases; Hypothalamo-Hypophyseal System; Lead Poisoning; Levulinic Acids; Melanocyte-Stimulating Hormones; Porphyrias; Propionates; Pyrroles; Thyrotropin; Vasopressins; Water-Electrolyte Balance