pituitrin and Hemorrhagic-Fever-with-Renal-Syndrome

Changes in blood plasma content of hormones which are observed in the different periods of hemorrhagic fever and the attendant renal syndrome are directed to the maintenance of significantly deranged water-electrolyte homeostasis. Adequate secretion of vasopressin and aldosterone in response to the changes in sodium concentration and plasma osmolality point to the absence of significant functional disorders of the corresponding glands. Pronounced hypernatremia in fatal cases is evidence of the deranged processes of osmoregulation associated primarily with kidney areactivity to vasopressin and prognostically is an unfavourable sign. The presence of pituitary necrosis in deceased subjects does not rule out the role of vasopressin deficiency in the pathogenesis of pronounced hypernatremia.

Topics: Acute Kidney Injury; Adolescent; Adult; Aldosterone; Female; Hemorrhagic Fever with Renal Syndrome; Humans; Hypernatremia; Hyponatremia; Male; Middle Aged; Nephrotic Syndrome; Osmotic Pressure; Renin; Vasopressins

A basal value of antidiuretic activity (ADA) of the plasma was determined in 79 HFRS patients and stimulated activity using the insulin tolerance test in 24 persons. A decrease in the plasma ADA was observed in the acute period of disease. The insulin tolerance test did not cause a statistically significant increment of the plasma ADA in the HFRS patients.

Topics: Adolescent; Adult; Convalescence; Hemorrhagic Fever with Renal Syndrome; Humans; Hypothalamo-Hypophyseal System; Insulin; Middle Aged; Oliguria; Polyuria; Time Factors; Vasopressins

Topics: Diuresis; Hemorrhagic Fever with Renal Syndrome; Humans; Kidney; Renal Insufficiency; Vasopressins