pituitrin and Hemophilia-A

Topics: Adrenal Cortex Hormones; Adult; Analgesics; Antifibrinolytic Agents; Blood Transfusion; Cardiovascular Diseases; Child; Contraceptives, Oral; Estrogens; Factor IX; Factor VIII; Gastrointestinal Diseases; Hemarthrosis; Hemophilia A; Hemophilia B; Hemorrhage; Home Nursing; Humans; Infections; Inhalation; Nervous System Diseases; Social Adjustment; Thyroxine; Triiodothyronine; Urologic Diseases; Vasopressins

Two children with bleeding from idiopathic thrombocytopenia with low factor VIII levels are described. The presence of a double haemostatic defect in an otherwise healthy individual presenting with bleeding is extremely rare. In both cases the atypical bleeding raised the suspicion of dual pathology.

Topics: Child, Preschool; Female; Hemophilia A; Hemorrhagic Disorders; Hemostatics; Humans; Infusions, Intravenous; Male; Purpura, Thrombocytopenic, Idiopathic; Vasopressins

Topics: Administration, Intranasal; Arginine Vasopressin; Hemophilia A; Humans; Vasopressins

Topics: Adult; Child; Deamino Arginine Vasopressin; Hemophilia A; Hemostasis; Humans; Middle Aged; Vasopressins

1-Deamino-8-d-arginine vasopressin (D.D.A.V.P.) infusion causes a marked increase in factor-VIII (antihaemophilic-factor)-related properties in patients with moderate and mild haemophilia and von Willebrand's disease (vWd). The possibility was therefore evaluated that such an autologous factor-VII response might be haemostatically effective, allowing patients to undergo surgery without plasma concentrates. 0.3 microng/kg of D.D.A.V.P. given before dental surgery and repeated in the early postoperative period was followed by a two to three fold rise in factor-VIII coagulant activity (VII C.A.) in four patients with moderate and mild haemophilia. In two, there was no abnormal bleeding after dental extraction, whereas plasma concentrates were necessary to control oozing from the sockets in the remaining two patients. A higher D.D.A.V.P. dosage (0.4-0.5 microng/kg) in patients with higherstarting VII C.A. (9% or more) was followed by a more marked response (four to six fold). VII C.A. levels up to 100% of average normal were achieved and dental extraction and major surgery (such as cholecystectomy, thoracotomy, and two tonsillectomies) were carried out successfullly in six patients with mild haemophilis and in two with vWd. The mean half-life of autologous VII C.A. was 9.4 h (range 7.5-11.6). Plasma and urine osmolality showed no consistent variation after drug administration. Thus D.D.A.V.P. appears a promision pharmacological alternative to plasma concentrates in the management of some patients with haemophilis and vWd.

Topics: Adolescent; Adult; Biopsy; Blood Coagulation Tests; Cholecystectomy; Deamino Arginine Vasopressin; Drug Evaluation; Factor VIII; Female; Hemophilia A; Hemorrhage; Hemostasis, Surgical; Humans; Infusions, Parenteral; Male; Middle Aged; Postoperative Care; Postoperative Complications; Preoperative Care; Thoracic Surgery; Thorax; Tonsillectomy; Tooth Extraction; Vasopressins; von Willebrand Diseases

Topics: Blood Coagulation; Deamino Arginine Vasopressin; Hemophilia A; Hemorrhage; Humans; Vasopressins; von Willebrand Diseases

Topics: Deamino Arginine Vasopressin; Factor VIII; Hemophilia A; Hemostasis, Surgical; Humans; Infusions, Parenteral; Male; Middle Aged; Postoperative Care; Preoperative Care; Tooth Extraction; Vasopressins

Topics: Adult; Deamino Arginine Vasopressin; Hemophilia A; Hemostasis, Surgical; Humans; Hyponatremia; Male; Tooth Extraction; Vasopressins; Water Intoxication

Topics: Arginine Vasopressin; Drug Evaluation; Female; Hemophilia A; Hemorrhage; Hemostasis, Surgical; Hemostatics; Humans; Postoperative Care; Postoperative Complications; Preoperative Care; Vasopressins; von Willebrand Diseases

1-Deamino-8-D-arginine vasopressin (DDAVP), a vasopressin analogue, increases factor VIII levels in plasma. A female carrier of haemophilia A with known bleeding diathesis and markedly reduced factor VIII activity was successfully treated with DDAVP during bilateral Caldwell-Luc's operation for chronic maxillary sinusitis. An estimated 5000 U factor VIII concentrate was calculated to have been saved. DDAVP is the first alternative to replacement therapy in the treatment of moderate and mold forms of haemophilia A and von Willebrand's disease.

Topics: Arginine Vasopressin; Factor VIII; Female; Hemophilia A; Humans; Maxillary Sinus; Middle Aged; Sinusitis; Vasopressins; von Willebrand Diseases

Topics: Biological Assay; Factor VIII; Hemophilia A; Humans; Immunoassay; Male; Vasopressins; Vasotocin

Topics: Aminocaproates; Ascorbic Acid; Factor VIII; Family; Hemophilia A; Hepatitis A; Hepatitis B Antigens; Home Nursing; Humans; Male; Tooth Extraction; Vasopressins

Topics: Arginine; Blood Coagulation Tests; Blood Platelets; Factor VIII; Hemophilia A; Humans; Ristocetin; Vasopressins; von Willebrand Diseases

Topics: Arginine Vasopressin; Blood Coagulation; Blood Vessels; Hemophilia A; Humans; Kidney; Serotonin; Serotonin Agents; Vasoconstriction; Vasopressins