pituitrin and Cyanosis

Topics: Clinical Trials as Topic; Cyanosis; Epinephrine; Humans; Lidocaine; Lysine; Ornithine; Oxytocin; Phenylalanine; Skin Transplantation; Vasopressins; Wound Healing

This "syndrome" has been observed in 4 of 23,935 in-patients registered in the years 1974-1987 in the Comprehensive Hospital Drug Monitoring (Bern/St. Gallen), with 6 reactions. Signs of an attack of bronchial asthma, laryngeal or pulmonary edema or a (heart-)circulatory event were not observed. Each patient was cyanotic and 3 had the feeling of impending death. The eliciting drugs were penicillin-G (twice) and cefazolin (once), given i.v.; iron dextran i.m. (once); pitressin tannate i.m. (once) and dicobalt edetate (Kelocyanor) i.v.(once). In each case the reaction started during or shortly after injection of the drug; the duration of the reaction in 5 of these events was 20-80 minutes. The pathomechanism could be a special form of anaphylactic reaction with acute pulmonary hypertension, comparable to IgE-induced anaphylaxis in the rabbit or aggregate anaphylaxis in the monkey or the dog. Further observations are needed for more detailed study.

Topics: Acute Disease; Adult; Arginine Vasopressin; Cefazolin; Chelating Agents; Cyanosis; Drug-Related Side Effects and Adverse Reactions; Dyspnea; Edetic Acid; Female; Humans; Iron-Dextran Complex; Male; Middle Aged; Penicillin G; Vasopressins

Topics: Chronic Disease; Cyanosis; Humans; Inflammation; Lung Diseases; Male; Middle Aged; Osteoarthropathy, Secondary Hypertrophic; Penicillins; Pneumoconiosis; Smoking; Syndrome; Tetracycline; Tomography, X-Ray; Vasopressins

Topics: Anesthesia; Anesthesia, Local; Arginine Vasopressin; Biomedical Research; Cyanosis; Epinephrine; Felypressin; Lidocaine; Norepinephrine; Oxygen; Pharmacology; Polarography; Skin; Statistics as Topic; Toxicology; Vasoconstrictor Agents; Vasomotor System; Vasopressins