pituitrin and Carcinoma--Bronchogenic

Topics: Adrenocorticotropic Hormone; Antigens, Neoplasm; Calcitonin; Calcium Metabolism Disorders; Carcinoembryonic Antigen; Carcinoma, Bronchogenic; Female; Growth Hormone; Hormones; Hormones, Ectopic; Humans; Inappropriate ADH Syndrome; Lung Neoplasms; Male; Paraneoplastic Endocrine Syndromes; Pituitary Hormones, Anterior; Prognosis; Secretory Component; Vasopressins

Topics: Adrenocorticotropic Hormone; Calcitonin; Carcinoma, Bronchogenic; Chorionic Gonadotropin; Growth Hormone; Hormones; Humans; Lung Neoplasms; Melanocyte-Stimulating Hormones; Parathyroid Hormone; Placental Lactogen; Vasopressins

Topics: Adrenocorticotropic Hormone; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Bronchogenic; Enzymes; Humans; Hypercalcemia; Lung Neoplasms; Neoplasm Metastasis; Placental Hormones; Vasopressins

Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Adult; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Chorionic Gonadotropin; Cushing Syndrome; Dexamethasone; Gynecomastia; Humans; Hypercalcemia; Lomustine; Lung Neoplasms; Male; Mechlorethamine; Neoplasm Metastasis; Neostigmine; Parathyroid Hormone; Smoking; Vasopressins; Water-Electrolyte Balance

Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Alkaline Phosphatase; alpha-Fetoproteins; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Bronchogenic; Chorionic Gonadotropin; Estradiol; Glucagon; Growth Hormone; Hormones, Ectopic; Humans; Insulin; Lung Neoplasms; Male; Melanocyte-Stimulating Hormones; Middle Aged; Parathyroid Hormone; Placental Lactogen; Polyamines; Prolactin; Vasopressins

Topics: Carcinoma, Bronchogenic; Cell Differentiation; Genes; Hormones, Ectopic; Humans; Liver Neoplasms; Lung Neoplasms; Microscopy, Electron; Mutation; Neoplasm Metastasis; Neoplasms; Paraneoplastic Endocrine Syndromes; Prognosis; Vasopressins

Topics: Adrenal Insufficiency; Carcinoma, Bronchogenic; Diagnosis, Differential; Hormones, Ectopic; Humans; Hyponatremia; Lung Neoplasms; Neurologic Manifestations; Phenytoin; Syndrome; Vasopressins

Topics: Carcinoma, Bronchogenic; Diuresis; Ethacrynic Acid; Hormones, Ectopic; Humans; Hyponatremia; Kidney Function Tests; Vasopressins

Vasopressin (ADH) was measured in CSF and plasma in 75 evaluable patients with known or suspected CNS metastases from small-cell bronchogenic carcinoma (SCBC), and in 66 control patients having neither malignant disease nor organic CNS disease. The presence of CNS metastases was confirmed or excluded on the basis of computed tomographic scans, neurologic examination, and autopsy. Twenty-four of the 75 patients had no CNS metastases. Ten of the 51 patients with CNS metastases had leptomeningeal carcinomatosis (MC). CSF-ADH was significantly increased in patients with MC (P less than .05), but not in patients having exclusively parenchymatous CNS metastases. Taking 2 pg/mL (95th percentile of control patients) as the upper limit of normal, 15 SCBC patients had elevated CSF-ADH, including 12 patients with CNS metastases and six patients with MC. The CSF-ADH to plasma ADH ratio was significantly increased in patients with CNS metastases (P less than .05). Patients without CNS metastases had a ratio less than or equal to 0.8 whereas the ratio was greater than 0.8, in 21 of the 51 patients with CNS metastases. The positive and negative predictive values with 95% confidence limits were 84% to 100% and 31% to 59%, respectively. Patients with inappropriate secretion of ADH (SIADH) constituted a significantly greater proportion of patients with elevated CSF-ADH than of patients with normal CSF-ADH levels (P less than .05). In addition, patients with SIADH constituted a significantly greater proportion of patients with MC than of patients with parenchymatous metastases (P less than .05). The diagnostic application of these findings is limited because of the large number of false-negative results, but it may prove to be of value in conjunction with the measurement of other tumor markers.

Topics: Carcinoma, Bronchogenic; Carcinoma, Small Cell; Central Nervous System Diseases; Humans; Inappropriate ADH Syndrome; Intracranial Pressure; Lung Neoplasms; Meningeal Neoplasms; Neoplasm Metastasis; Vasopressins

We measured basal and dexamethasone-suppressed plasma ACTH in 246 patients with bronchogenic carcinoma (105 with small-cell carcinoma); in 138 of these patients (67 with small-cell carcinoma) basal and pentagastrin-stimulated serum calcitonin was also determined. In addition, in a subgroup of 120 patients (58 with small-cell carcinoma) plasma ADH with reference to plasma osmolality was also assayed. Non-suppressible plasma ACTH was found in 45% of patients with small-cell carcinoma but only in isolated cases of large-cell carcinoma, adenocarcinoma, and squamous-cell carcinoma. Serum calcitonin was increased in 28% of patients with small-cell carcinoma but only in few patients with other tumor types. Stimulation of calcitonin by pentagastrin was ineffective. Plasma ADH was inappropriately high in 47% of patients with small-cell carcinoma. Strikingly high also was the incidence of increased ADH concentrations in patients with large-cell (40%), adenocarcinoma (46%), and squamous-cell carcinoma (29%). By measuring plasma ACTH after dexamethasone suppression and ADH with reference to osmolality, the sensitivity of these tumor markers in detecting pathological hormone secretion is markedly increased. In small-cell carcinoma the simultaneous measurement of ACTH, ADH, and calcitonin gives a high yield of positive results (74%), indicating that this set of tumor markers is a promising aid in diagnosis and therapy control.

Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Calcitonin; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Dexamethasone; Humans; Kinetics; Lung Neoplasms; Pentagastrin; Vasopressins

Topics: Adrenocorticotropic Hormone; APUD Cells; Calcitonin; Carcinoma, Bronchogenic; Chorionic Gonadotropin; Female; Hormones, Ectopic; Humans; Lung Neoplasms; Male; Vasopressins

We report a patient who had an oat cell bronchogenic carcinoma in association with the syndrome of inappropriate antidiuresis. There was an unusually long interval between the onset of hyponatraemia and clinically evident malignant disease. Dynamic testing of vasopressin secretion showed preservation of baroregulated, but not osmoregulated, vasopressin release. Immunoreactive vasopressin was detected in pleural fluid, which co-eluted with synthetic vasopressin on gel chromatography.

Topics: Carcinoma, Bronchogenic; Carcinoma, Small Cell; Humans; Inappropriate ADH Syndrome; Lung Neoplasms; Male; Middle Aged; Vasopressins

A 58-year-old man with bronchogenic oat cell carcinoma developed a typical syndrome of inappropriate secretion of antidiuretic hormone. The tumor tissue obtained at autopsy had been serially transplanted in nude mice for more than four years with 20 passages. The levels of vasopressin were remarkably increased in the plasma of nude mice bearing this tumor [24.4 +/- 18.3 (S.D.) pg/ml, n = 3] as well as in the tumor tissues ]134.3 +/- 72.2 ng/g, n = 3]. Furthermore, human nicotine-stimulated neurophysin was detected in both plasma and tumor tissues (7.4 +/- 3.7 ng/ml, n = 3, and 2.28 +/- 0.90 micrograms/g, n = 3, respectively). On ad libitum intake of water, nude mice bearing this tumor excreted significantly less urine with higher sodium concentration than did controls, but serum sodium concentrations did not differ from those of controls. When tumor-bearing mice were hydrated with 2 ml of water twice a day i.p., their diuretic response was found to be suppressed in parallel with the tumor size. However, these mice did not become hyponatremic because they drank less water. When a larger amount of water was loaded which could not be compensated by restriction of water drinking, serum sodium concentrations were markedly decreased. On the basis of these results, the lung cancer, when transplanted into nude mice, produced and secreted its own antidiuretic hormone, which induced inappropriate secretion of antidiuretic hormone in the mice. These mice may provide a useful experimental model for the study of excessive secretion of antidiuretic hormone and associated pathophysiological disorders.

Topics: Animals; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Drinking; Female; Humans; Inappropriate ADH Syndrome; Lung Neoplasms; Male; Mice; Mice, Nude; Middle Aged; Natriuresis; Neoplasm Transplantation; Sodium; Transplantation, Heterologous; Vasopressins

Hypouricaemia has been observed in patients with the syndrome of inappropriate secretion of antidiuretic hormone (IADH). Accordingly, 69 patients with untreated bronchogenic small cell carcinoma were examined for IADH. Serum urate was also measured. IADH was proven in 25 (35%) of the 69 patients. The median serum concentration of urate in these patients was 0.26 mmol/l (range 0.13-0.50), compared to 0.36 mmol/l (0.21-0.60) in the 44 patients without IADH. The difference is statistically significant (p less than 0.01), but serum urate--when used alone--is lacking in both sensitivity and specificity for the diagnosis of IADH.

Topics: Carcinoma, Bronchogenic; Carcinoma, Small Cell; Female; Humans; Inappropriate ADH Syndrome; Lung Neoplasms; Male; Uric Acid; Vasopressins

Topics: Adrenocorticotropic Hormone; Calcitonin; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Humans; Lung Neoplasms; Prognosis; Vasopressins

Topics: Adrenocorticotropic Hormone; Antigen-Antibody Complex; Calcitonin; Carcinoma, Bronchogenic; Cytoplasmic Granules; Humans; Lung Neoplasms; Parathyroid Hormone; Peptides; Prostaglandins; Vasopressins

Topics: Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Lung Neoplasms; Molecular Weight; Oxytocin; Vasopressins

Forty-one patients with newly diagnosed small cell anaplastic lung cancer were evaluated for abnormalities in water homeostasis. Each patient underwent a standard water load (SWL) test. Overall, 68% had abnormalities in the SWL test. Abnormalities were found in 47% of the patients with carcinoma clinically limited to one hemithorax and in 86% of the patients with more extensive carcinoma. The determination of urinary antidiuretic hormone levels was available for 27 patients. Abnormally elevated levels were found in 44% of those patients. Forty-six patients had clinically detectable syndrome of the inappropriate secretion of antidiuretic hormone (SIADH); in 12% of patients water restriction was necessary. The incidence of detectable abnormalities in water homeostasis in this study was higher than has been previously recognized. The SWL test is a sensitive and useful means of determining the presence of impaired water handling in patients with small cell carcinoma of the lung.

Topics: Blood Urea Nitrogen; Carcinoma; Carcinoma, Bronchogenic; Drug Therapy, Combination; Female; Homeostasis; Humans; Inappropriate ADH Syndrome; Lung Neoplasms; Male; Methods; Vasopressins; Water; Water-Electrolyte Balance

Serum potassium concentration was normal (greater than or equal to 3.6 mmol/l) in 29 of 32 patients with the syndrome of inappropriate antidiuretic hormone excess (SIADH) associated with a bronchogenic carcinoma. In 11 of the patients there was no significant change in serum potassium concentration after correction of the syndrome, by fluid restriction. Hypokalaemia is thus an uncommon finding in SIADH due to bronchogenic carcinomas.

Topics: Aged; Carcinoma, Bronchogenic; Female; Humans; Inappropriate ADH Syndrome; Lung Neoplasms; Male; Middle Aged; Osmolar Concentration; Potassium; Vasopressins

Immunoactive antidiuretic hormone (ADH) was measured by radioimmunoassay in the plasma, lung tumours and metastatic tumours of nineteen patients with bronchogenic carcinoma. Ten patients had hyponatraemia and carcinoma of the small oat cell type. Plasma ADH measured in nine of these patients ranged from 11--270 pg/ml and was elevated above the normal range (4.6--6.2 pg/ml) in all subjects. ADH-immunoreactive material was detectable in all primary lung tumours (range 9--1080 pg/mg wet weight, n = 7) and metastases (range 5--63 pg/mg wet weight, n = 9) obtained from the hyponatraemic patients. A statistical relationship existed between plasma and tumour ADH concentration in six patients where both measurements were performed. Three patients had small cell carcinomas (two oat cell and one anaplastic) without overt hyponatraemia. ADH-like material was detectable in the lung tumours (18 and 1.1 pg/mg wet weight) and liver metastases (4 and 1.0 pg/mg wet weight) of two patients but not in the third. Four of the remaining patients had squamous cell carcinomas and two had adenocarcinomas. None had hyponatraemia. ADH-like material was undetectable in all lung tumours, metastatic tumours and uninvolved tissue from these patients. ADH extracted from the pituitaries of four patients ranged from 6400--13200 pg/mg wet weight. ADH immunoreactive extracts of six lung tumours and nine metastases (all oat cell) showed the same pattern on elution from a Sephadex G-25 column. A large peak, which made up 65% of the total activity, was eluted in the same position as synthetic arginine vasopressin and contained comparable amounts of immunoreactive and bioactive ADH. Two smaller peaks (8 and 27% of total activity) were eluted in positions of higher molecular weight and contained more immunoreactive than bioactive ADH. In contrast, three of four pituitary extracts showed only a single peak which eluted in the same position as marker vasopressin.

Topics: Carcinoma, Bronchogenic; Carcinoma, Small Cell; Chromatography, Affinity; Chromatography, Gel; Female; Humans; Lung Neoplasms; Male; Neoplasm Metastasis; Sodium; Vasopressins

Topics: Carcinoma, Bronchogenic; Deficiency Diseases; Humans; Hyponatremia; Male; Methods; Middle Aged; Syndrome; Vasopressins

Twenty-six patients with the syndrome of inappropriate secretion of antidiuretic hormone were reviewed. The underlying diseases were bronchogenic carcinoma (12 cases); myxoedema (five cases); diseases of the nervous system (five cases); bronchopneumonia, carcinoma of the oesophagus, acute intermittent porphria and chlorpropamide therapy (each one case). Serum sodium levels ranged between 104 and 125 mEq per litre. Eighteen patients presented neurological manifestations, which in 14 were considered to be due to hyponatraemia. Neurological signs included disorders of consciousness (stage I and II coma), extrapyramidal signs, asterixis and epileptic seizures. An hyponatraemic coma was the first manifestation of the syndrome in five cases. In all cases where the EEG was recorded it showed non-specific signs of metabolic coma. The fundi never showed signs of intracranial hypertension. Blood urea and creatinine levels were invariably low in the euthyroid patients; these values were normal or elevated in patients with myxoedema and hyponatraemia. Hypokalaemia was frequent, and hypocalcaemia constant. In eleven cases an excess of water intake revealed the clinical syndrome: six patients were excessive beer drinkers and five had received extensive intravenous infusions. In one case the deleterious effect of diuretics was evident, and in another, the syndrome became evident during radiotherapy of an oesophageal tumour. Treatment of the syndrome was successful in all cases. A review of the literature concerning the various pathogenic mechanisms corresponding to the different underlying diseases is presented. The concept of aberrant hormonal production by a tumour is illustrated by an electron microscopic study.

Topics: Adult; Aged; Carcinoma, Bronchogenic; Cerebrovascular Disorders; Esophageal Neoplasms; Female; Hormones, Ectopic; Humans; Hyponatremia; Hypothyroidism; Lung Neoplasms; Male; Middle Aged; Myxedema; Neurologic Manifestations; Vasopressins; Water Intoxication

A study of plasma arginine vasopressin in 17 patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) associated with bronchogenic carcinoma, revealed that the arginine vasopressin levels were distinctly elevated in most. In 14 patients with bronchogenic carcinoma, but without overt SIADH, plasma levels of arginine vasopressin were significantly higher than in normal subjects (p less than 0.001). This, together with the finding of a lower than normal plasma osmolality in this group, suggests that inappropriate ADH excess might be much more common in patients with bronchogenic carcinoma than previously thought. The normal positive correlation between plasma osmolality and plasma arginine vasopressin was found to be reversed in SIADH. Seven of nine patients with overt SIADH, studied after fluid deprivation, showed an increase in plasma arginine vasopressin coincident with an increase in plasma osmolality (r = +0.8, p less than 0.01); in one patient, plasma arginine vasopressin returned to the original level following rehydration. The possibility that this might imply a degree of physiologic control to what is generally considered an autonomous secretion is discussed. It is, however, considered more likely that other factors, including changes in plasma volume and glomerular filtration, might explain the increase in plasma levels of arginine vasopressin.

Topics: Adult; Aged; Arginine Vasopressin; Carcinoma, Bronchogenic; Female; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Osmolar Concentration; Syndrome; Vasopressins; Water Deprivation

Topics: Adrenocorticotropic Hormone; Alkalosis; Bicarbonates; Breast Neoplasms; Calcium; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Female; Gentamicins; Hodgkin Disease; Hormones, Ectopic; Humans; Hydrocortisone; Hyponatremia; Hypothalamus; Lung Neoplasms; Paraneoplastic Endocrine Syndromes; Phosphates; Potassium; Vasopressins

Topics: Benzothiadiazines; Body Water; Carcinoma, Bronchogenic; Chlorpropamide; Dehydration; Diuretics; Edema; Humans; Hyponatremia; Sodium; Sodium Chloride Symporter Inhibitors; Vasopressins; Water Intoxication

Topics: Adenocarcinoma; Animals; Carcinoma, Bronchogenic; Choriocarcinoma; Culture Media; Diuresis; Female; In Vitro Techniques; Liver; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Oxytocin; Pancreatic Neoplasms; Pregnancy; Rats; Recurrence; Uterine Neoplasms; Vasopressins

Topics: Autopsy; Brain Neoplasms; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Humans; Hypopituitarism; Hypothalamus; Male; Microscopy, Electron; Middle Aged; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Pituitary Gland; Pituitary Neoplasms; Vasopressins

Topics: Adult; Aldosterone; Autopsy; Bronchoscopy; Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Renin; Vasopressins

Topics: Adult; Aged; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Diuresis; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neurophysins; Protein Binding; Radioimmunoassay; Syndrome; Tongue Neoplasms; Vasopressins

Topics: Adult; Autopsy; Bicarbonates; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Chlorides; Cyclophosphamide; Hormones, Ectopic; Humans; Hyponatremia; Injections, Intravenous; Male; Osmolar Concentration; Sodium; Urea; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Diet; Hormones, Ectopic; Humans; Hyponatremia; Male; Natriuresis; Paraneoplastic Endocrine Syndromes; Sodium; Vasopressins; Water-Electrolyte Balance

Tumors from patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) have been found to contain large amounts of the antidiuretic hormone vasopressin. A lung tumor from a patient with hyponatremia most likely due to SIADH was removed at surgery and found to contain 23.5 mU vasopressin/g wet weight by radioimmunoassay Slices of this tumor were incubated with phenylalanine-(3)H. Arginine vasopressin-(3)H was purified from the incubate by Sephadex G-25 column chromatography in two different systems, performic acid oxidation, and gradient elution column chromatography with diethylaminoethyl Sephadex. As oxidation of vasopressin results in drastic conformational change with breaking of the ring of the cyclic polypeptide and addition of two cysteic acid residues per molecule, the radioactive material which eluted coincident with vasopressin both before and after this procedure was considered to be arginine vasopressin-(3)H. To our knowledge this is the first demonstration of in vitro biosynthesis of vasopressin by a tumor from a patient with SIADH.Ultrastructurally, the bronchogenic carcinoma was composed of small undifferentiated and granulated cells. The granulated neoplastic cells had well developed organelles (endoplasmic reticulum, free ribosomes) concerned with protein synthesis. Secretion granules present in the tumor cells were small, surrounded by a limiting membrane, and resembled those reported in polypeptide hormone-secreting cells.

Topics: Aged; Carcinoma, Bronchogenic; Chromatography, DEAE-Cellulose; Culture Techniques; Cytoplasmic Granules; Endoplasmic Reticulum; Hormones, Ectopic; Humans; Hyponatremia; Lung; Lung Neoplasms; Male; Microscopy, Electron; Radioimmunoassay; Ribosomes; Vasopressins

Topics: Carcinoma, Bronchogenic; Endocrine System Diseases; Estrogens; Gynecomastia; Humans; Liver; Male; Middle Aged; Sodium; Vasopressins

Topics: Carcinoma, Bronchogenic; Craniocerebral Trauma; Diuresis; Drinking; Extracellular Space; Humans; Hypertonic Solutions; Hyponatremia; Lung Neoplasms; Methods; Nicotine; Osmolar Concentration; Pituitary Function Tests; Porphyrias; Sodium Chloride; Vasopressins

Topics: Aged; Carcinoma, Bronchogenic; Humans; Lung Neoplasms; Male; Metabolic Diseases; Vasopressins

Topics: Brain Diseases; Carcinoma, Bronchogenic; Humans; Hypernatremia; Hyponatremia; Vasopressins

Topics: Carcinoma, Bronchogenic; Craniocerebral Trauma; Humans; Lung Neoplasms; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Amino Acids; Animals; Biological Assay; Carcinoma, Bronchogenic; Corticotropin-Releasing Hormone; Dexamethasone; Electrophoresis; Feedback; Hormones, Ectopic; Humans; Lung Neoplasms; Lysine; Metyrapone; Neoplasm Metastasis; Neoplasm Proteins; Pancreatic Neoplasms; Peptides; Rats; Vasopressins

Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenocortical Hyperfunction; Bronchial Neoplasms; Carcinoma, Bronchogenic; Female; Hormones, Ectopic; Humans; Hypercalcemia; Hyponatremia; Neoplasm Metastasis; Vasopressins

Ectopic production of polypeptide hormones by tumors of nonendocrine tissues can serve as a clue to diagnosis of the tumor and as a focus for management of the patient with cancer. In the differential diagnosis of syndromes of endocrine hyperfunction, the ectopic hormone syndromes have achieved an increasingly prominent position. Available evidence on the properties of ectopic ACTH, MSH, parathyroid hormone, erythropoietin, gonadotropins, and thyrotropin is consistent with the unifying hypothesis of genetic derepression.

Topics: Abdominal Neoplasms; Adenocarcinoma; Adrenocortical Hyperfunction; Brain Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Hepatocellular; Carcinoma, Small Cell; Cysts; Diagnosis, Differential; Fibroma; Hemangiosarcoma; Humans; Hyperparathyroidism; Hypoglycemia; Kidney Diseases; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Paraneoplastic Endocrine Syndromes; Pheochromocytoma; Polycythemia; Sarcoma; Thoracic Neoplasms; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Female; Hormones, Ectopic; Humans; Hyponatremia; Middle Aged; Vasopressins

Topics: Aged; Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Pituitary Diseases; Tuberculosis; Vasopressins

Topics: Biopsy; Carcinoma, Bronchogenic; Electromyography; Hormones, Ectopic; Humans; Hyponatremia; Hypoventilation; Lung Neoplasms; Male; Middle Aged; Muscular Diseases; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Hyponatremia; Hypoventilation; Lung Neoplasms; Male; Middle Aged; Muscular Diseases; Myositis; Vasopressins

Topics: Adolescent; Adult; Aged; Animals; Carcinoma, Bronchogenic; Central Nervous System Diseases; Child; Diuretics; Dogs; Electroencephalography; Female; Glomerular Filtration Rate; Humans; Hyponatremia; Hypothyroidism; Iatrogenic Disease; Kidney; Kidney Concentrating Ability; Lung Neoplasms; Male; Middle Aged; Neurologic Manifestations; Polyradiculopathy; Rats; Vasopressins

Topics: Animals; Antibodies, Anti-Idiotypic; Arginine; Carcinoma, Bronchogenic; Humans; Lung Neoplasms; Lysine; Rabbits; Radioimmunoassay; Vasopressins

Topics: Carcinoma, Bronchogenic; Humans; Hyponatremia; Lung Neoplasms; Vasopressins

Topics: Aged; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Hormones, Ectopic; Humans; Hyponatremia; Male; Mental Disorders; Vasopressins; Water-Electrolyte Balance

Topics: Amino Acid Sequence; Arginine; Carcinoma, Bronchogenic; Chromatography, Gel; Hormones, Ectopic; Humans; Hyponatremia; Iodine Isotopes; Lysine; Methods; Nicotine; Osmolar Concentration; Plasma; Radioimmunoassay; Urine; Vasopressins; Water Deprivation

Topics: Animals; Biological Assay; Bronchial Neoplasms; Carcinoma, Bronchogenic; Chlorpropamide; Diabetes Insipidus; Female; Hemorrhage; Humans; Immune Sera; Labor, Obstetric; Nicotine; Pregnancy; Radioimmunoassay; Sheep; Vasopressins

Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Carcinoma, Bronchogenic; Cushing Syndrome; Diagnosis, Differential; Female; Gonadotropins; Hormones, Ectopic; Humans; Hypopituitarism; Lung Neoplasms; Male; Parathyroid Hormone; Vasopressins

Topics: Adrenocorticotropic Hormone; Alkalosis; Carcinoma, Bronchogenic; Diabetes Complications; Humans; Hyperthyroidism; Hypokalemia; Male; Middle Aged; Smoking; Vasopressins

Topics: Adrenalectomy; Adrenocorticotropic Hormone; Alkalosis; Autoimmune Diseases; Bone Diseases; Carcinoma, Bronchogenic; Cushing Syndrome; Endocrine System Diseases; Hypercalcemia; Hyperparathyroidism; Hyponatremia; Lung Neoplasms; Metabolic Diseases; Neoplasm Metastasis; Neurologic Manifestations; Neuromuscular Diseases; Skin Diseases; Skin Manifestations; Vascular Diseases; Vasopressins

Topics: Brain Diseases; Carcinoma, Bronchogenic; Humans; Lung Diseases; Osmosis; Phenytoin; Urination; Vasopressins; Water-Electrolyte Balance

Topics: Adult; Carcinoma, Bronchogenic; Cryptococcosis; Granuloma; Hormones, Ectopic; Humans; Hypercalcemia; Lung Diseases; Lung Diseases, Fungal; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Nephrocalcinosis; Radiography, Thoracic; Vasopressins

In an unselected series of 185 patients with histologically confirmed bronchial carcinoma 16 had endocrine disturbances attributable to the tumour (excluding pulmonary osteoarthropathy). Of these, 11 patients had hypercalcaemia; three inappropriate secretion of antidiuretic hormone; one Cushing's disease; three hypertrophic osteoarthropathy; and one gynaecomastia. Cushing's disease and inappropriate antidiuresis are specifically associated with oat-cell tumours, and hypercalcaemia occurs most frequently with squamous carcinoma. A negative correlation exists between gynaecomastia and osteoarthropathy on the one hand and oat-cell carcinoma on the other.

Topics: Adenocarcinoma; Bronchial Neoplasms; Carcinoid Tumor; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Chlorides; Cushing Syndrome; Endocrine System Diseases; Gynecomastia; Humans; Hydrocortisone; Hypercalcemia; Osteoarthropathy, Primary Hypertrophic; Sodium; Urea; Vasopressins

Topics: Aged; Carcinoma, Bronchogenic; Central Nervous System Diseases; Hormones, Ectopic; Humans; Hyponatremia; Lung Diseases; Male; Middle Aged; Vasopressins

Topics: Carbon Isotopes; Carcinoma, Bronchogenic; Humans; Hyperaldosteronism; Leucine; Lung Neoplasms; Male; Middle Aged; Radioimmunoassay; Tritium; Tyrosine; Vasopressins

Topics: Aged; Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Vasopressins

Topics: Biopsy; Bronchi; Bronchial Neoplasms; Carcinoma, Bronchogenic; Cell Nucleolus; Cilia; Epithelium; Humans; Microscopy, Electron; Vasopressins

Topics: Brain Neoplasms; Carcinoma, Bronchogenic; Cerebral Cortex; Dementia; Glioma; Humans; Hyponatremia; Liver Neoplasms; Lymph Nodes; Male; Mental Disorders; Middle Aged; Neoplasm Metastasis; Seizures; Sodium; Thalamus; Vasopressins

Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenocorticotropic Hormone; Aged; Carcinoma, Bronchogenic; Electrolytes; Hormones; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Osmolar Concentration; Sodium Chloride; Vasopressins; Water-Electrolyte Balance

Topics: Adenocarcinoma; Carcinoma, Bronchogenic; Female; Humans; Iodine Isotopes; Lung Neoplasms; Middle Aged; Neoplasm Metastasis; Vasopressins

Topics: Adult; Atropine; Carcinoma, Bronchogenic; Ethanol; Glucose; Humans; Male; Neoplasm Metastasis; Vasopressins; Water-Electrolyte Balance

Topics: Carcinoma, Bronchogenic; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Thirst; Vasopressins

Topics: Animals; Carcinoma, Bronchogenic; Diuresis; Female; Glycolates; Humans; Plasma; Pregnancy; Rats; Thioglycolates; Tissue Extracts; Vasopressins

Topics: Animals; Biological Assay; Carcinoma, Bronchogenic; Female; Hormones, Ectopic; Humans; Immunoassay; Lactation; Lung Neoplasms; Mammary Glands, Animal; Pregnancy; Rats; Tissue Extracts; Vasopressins

Topics: Adenocarcinoma; Animals; Biological Assay; Carcinoma, Bronchogenic; Chickens; Humans; Hyponatremia; Lung Neoplasms; Male; Methods; Middle Aged; Neoplasm Metastasis; Neoplasms, Multiple Primary; Osmolar Concentration; Oxytocin; Pancreatic Neoplasms; Pneumonectomy; Rabbits; Radioimmunoassay; Rats; Vasopressins

Topics: Carcinoma, Bronchogenic; Endocrine System Diseases; Hormones, Ectopic; Humans; Hyponatremia; Infections; Lung Neoplasms; Male; Middle Aged; Myxedema; Pituitary Diseases; Porphyrias; Vasopressins

Topics: Animals; Anura; Biological Assay; Carcinoma, Bronchogenic; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Diuresis; Hormones, Ectopic; Humans; Hyponatremia; Liver Neoplasms; Lymphatic Metastasis; Neoplasm Metastasis; Pancreatic Neoplasms; Thioglycolates; Trypsin; Vasopressins

Topics: Animals; Biological Assay; Carcinoma, Bronchogenic; Diabetes Insipidus; Humans; Rats; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Humans; Vasopressins

Topics: Aged; Aldosterone; Body Weight; Carcinoma, Bronchogenic; Erythrocytes; Feces; Female; Humans; Hyponatremia; Male; Middle Aged; Muscles; Vasopressins; Water-Electrolyte Balance

Topics: Afibrinogenemia; Autonomic Nervous System Diseases; Bone Diseases; Carcinoma, Bronchogenic; Collagen Diseases; Cushing Syndrome; Endocrine System Diseases; Fibrinolysis; Hematologic Diseases; Humans; Hypercalcemia; Lung Neoplasms; Muscular Diseases; Neurologic Manifestations; Osteoarthropathy, Secondary Hypertrophic; Pathology; Peripheral Nervous System Diseases; Spinal Cord; Thrombophlebitis; Vascular Diseases; Vasopressins

Topics: Arginine Vasopressin; Bronchial Neoplasms; Carcinoma, Bronchogenic; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lymphatic Metastasis; Natriuresis; Neoplasms; Physiology; Urine; Vasopressins

Topics: Carcinoma; Carcinoma, Bronchogenic; Fluids and Secretions; Humans; Metabolism; Urine; Vasopressins

Topics: Arginine Vasopressin; Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Drug Therapy; Fluids and Secretions; Humans; Hyponatremia; Mechlorethamine; Neoplasms; Urine; Vasopressins

Topics: Biological Assay; Blood; Carcinoma; Carcinoma, Bronchogenic; Humans; Liver Neoplasms; Neoplasm Metastasis; Vasopressins

Topics: Carcinoma; Carcinoma, Bronchogenic; Humans; Hyponatremia; Lung Neoplasms; Mediastinal Neoplasms; Renal Elimination; Urine; Vasopressins; Water-Electrolyte Balance

Topics: Carcinoma; Carcinoma, Bronchogenic; Humans; Hyponatremia; Sodium; Vasopressins

Topics: Carcinoma; Carcinoma, Bronchogenic; Diabetes Insipidus, Neurogenic; Humans; Hyponatremia; Kidney; Sodium; Vasopressins