pituitrin and Bronchial-Neoplasms

Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Arginine; Biliary Tract Diseases; Bronchial Neoplasms; Carcinoma; Chorionic Gonadotropin; Colonic Neoplasms; Cushing Syndrome; Erythropoietin; Female; Follicle Stimulating Hormone; Growth Hormone; Gynecomastia; Hormones, Ectopic; Humans; Hypercalcemia; Lactation Disorders; Lung Neoplasms; Luteinizing Hormone; Models, Biological; Neoplasms; Paraganglioma; Paraneoplastic Endocrine Syndromes; Polycythemia; Pregnancy; Prolactin; Thyroid Neoplasms; Vasopressins

Topics: Adrenocorticotropic Hormone; Bronchial Neoplasms; Calcitonin; Carcinoma, Small Cell; Erythropoietin; Fluorescent Antibody Technique; Gastrointestinal Hormones; Gonadotropins, Pituitary; Growth Hormone; Histocytochemistry; Hormones, Ectopic; Humans; Hypercalcemia; Insulin; Insulin Secretion; Neoplasm Metastasis; Neurophysins; Oxytocin; Paraneoplastic Endocrine Syndromes; Parathyroid Hormone; Placental Lactogen; Prolactin; Thyrotropin; Vasopressins

Topics: Adolescent; Bronchial Neoplasms; Carcinoma, Small Cell; Child, Preschool; Cushing Syndrome; Diagnosis, Differential; Hormones, Ectopic; Humans; Hyperaldosteronism; Hypercalcemia; Hyperparathyroidism; Hyponatremia; Kidney Neoplasms; Paraneoplastic Endocrine Syndromes; Renin; Sodium Chloride; Syndrome; Vasopressins

Topics: Adrenocorticotropic Hormone; Bronchial Neoplasms; Carcinoid Tumor; Cushing Syndrome; Endocrine System Diseases; Female; Gonadotropins; Hormones, Ectopic; Humans; Islets of Langerhans; Male; Neoplasms; Parathyroid Hormone; Thymus Neoplasms; Thyroid Neoplasms; Vasopressins

Topics: Brain Diseases; Bronchial Neoplasms; Deficiency Diseases; Diuresis; Ethanol; Hyponatremia; Kidney Concentrating Ability; Natriuresis; Respiratory Tract Diseases; Vasopressins

Topics: Adrenocorticotropic Hormone; Alkaline Phosphatase; Bronchial Neoplasms; Endocrine System Diseases; Gonadotropins; Growth Hormone; Humans; Insulin; Insulin Secretion; Metabolic Diseases; Thyrotropin; Vasopressins

Topics: Bone Marrow Transplantation; Bronchial Neoplasms; Carcinoma, Small Cell; Cyclophosphamide; Dehydration; Diabetes Insipidus; Humans; Kidney Diseases; Liver Neoplasms; Male; Middle Aged; Vasopressins

An autopsy case of a 67-year-old Japanese male is presented. He had been suffering from carcinoid syndrome for 5 years and showed a typical picture of carcinoid heart disease. In Japan, carcinoid heart disease is rare and we can find only four reported cases (33% of reported carcinoid syndrome). The patient had high urinary secretion of 5-HIAA and high serum serotonin, and finally he died of heart failure and bronchopneumonia. The primary site of this carcinoid tumor was of the bronchus of the right B10c , and it had large hepatic metastases. Electronmicroscopically, the tumor cells had secretory granules measuring 1500-3500 A in diameter. Immunohistochemically, the tumor cells were markedly positive for human chorionic gonadotropin (hCG) and antidiuretic hormone (ADH) and positive for serotonin, in both the primary site and hepatic metastases. Characteristic fibrous plaques were detected in the right atrium, tricuspid valve, right ventricle, and left atrium. Electron-microscopically, the fibrous plaques consisted of smooth muscle cells and myofibroblasts surrounded by basement membrane-like material. The abundant matrix of the fibrous plaques contained acid mucopolysaccharide, microfibrils and collagen fibers. The same fibrous plaques were also found in hepatic veins. Furthermore, retroperitoneal fibrosis was present, which showed proliferation of myofibroblasts, fibroblasts and immature mesenchymal cells.

Topics: Aged; Bronchi; Bronchial Neoplasms; Carcinoid Heart Disease; Carcinoid Tumor; Chorionic Gonadotropin; Humans; Male; Malignant Carcinoid Syndrome; Microscopy, Electron; Myocardium; Neoplasm Metastasis; Retroperitoneal Fibrosis; Serotonin; Vasopressins

Antidiuretic hormone (ADH) was determined by radioimmunoassay in 139 patients with bronchial carcinoma. Serum ADH levels, compared with a control group, were increased in 30% of patients with small-cell and 21% of patients with large-cell bronchial carcinoma. Patients with squamous carcinoma or adenocarcinoma had normal ADH values. There was no correlation between serum ADH levels and stage of tumour. Serial ADH measurements during chemotherapy provided good correlation between ADH and response to treatment. ADH was also demonstrable by immunohistology in the tumour cells of one patient with increased serum levels.

Topics: Adenocarcinoma; Bronchial Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Neoplasm Staging; Radioimmunoassay; Vasopressins

Topics: Bronchial Neoplasms; Cushing Syndrome; Hormones, Ectopic; Humans; Hypercalcemia; Paraneoplastic Endocrine Syndromes; Vasopressins

Topics: Bronchial Neoplasms; Calcitonin; Carcinoma, Small Cell; Hormones; Humans; Hydrocortisone; Lung Neoplasms; Male; Melanocyte-Stimulating Hormones; Middle Aged; Peptide Biosynthesis; Vasopressins

Topics: Adult; Bronchial Neoplasms; Carcinoma; Guanidines; Humans; Hyponatremia; Male; Muscular Diseases; Osmolar Concentration; Syndrome; Vasopressins

Topics: Bronchial Neoplasms; Hormones, Ectopic; Humans; Male; Middle Aged; Paraneoplastic Endocrine Syndromes; Sodium; Vasopressins

Daily arginine-vasopressin (AVP) excretion was determined by radioimmunoassay in 60 consecutive cases of untreated lung carcinoma. Control excretion was 61 +/- 34 (SD) in 41 healthy subjects and 50 +/- 38 ng/24 h in 10 patients with chronic lung diseases. Overall 20 out of the 60 cases of lung carcinoma presented with abnormally elevated urinary AVP; In the group with anaplastic oat-cell carcinoma, 15 of 23 had elevated urinary AVP with a mean of 370 +/- 331 (SD) ng/24 h if 2 cases with extremely high values of 11 100 and 55 300 ng/24 h respectively are excluded. None of the 9 patients with large-cell carcinoma had elevated urinary AVP, while only 3 of the 19 cases of epidermoid carcinoma and 2 of the 9 cases of adenocarcinoma had high urinary AVP, with means of 127 +/- 8 and 125 +/- 12 ng/24 h respectively. Plasma osmolality and sodium correlated inversely with AVP excretion. However, only 10 of 23 patients with increased urinary AVP had decreased plasma sodium, although one became hyponatremic 9 weeks later. In one patient AVP excretion normalized after radiotherapy. Plasma renin activity and urinary aldosterone were usually low when urinary AVP was high. Two cases with elevated plasma luteotrophic hormone and another with elevated plasma ACTH, all three presenting with oat-cell carcinoma, were found;

Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Aldosterone; Bronchial Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Humans; Luteinizing Hormone; Renin; Sodium; Vasopressins

Topics: Adrenocorticotropic Hormone; Bronchial Neoplasms; Calcitonin; Melanocyte-Stimulating Hormones; Paraneoplastic Endocrine Syndromes; Vasopressins

Topics: Bronchial Neoplasms; Humans; Hypertension; Radioimmunoassay; Vasopressins

A radioimmunoassay has been developed for plasma arginine-vasopressin in man and dog. The mean recovery of added arginine-vasopressin (AVP) was 60 +/-6.9 (S.D.)% and the lower threshold of detection 2.0 pmol/1. A close correlation was found between concurrent radioimmunoassay and bioassay values. The mean concentration found in peripheral venous blood in healthy men after overnight fasting was 5.3 pmol/1 (range 4.6-6.2 pmol/1.) In man, significant increases in plasma AVP occurred after dehydration (5-9-9-5 pmol/1) and significant decreases after oral water-loading (5.9-9.5 pmol/1). During i.v. infusion of graded doses of synthetic AVP in normal men, plasma levels were closely correlated with infusion rate. On stopping the infusion, plasma vasopressin fell exponentially with a half-life of between 7 and 8 min. In man, plasma AVP was unaffected by tilting head-up for 2 h, or by a non-hypotensive bleeding of 500 ml in 10 min. In the dog, haemorrhage of 5 ml/kg and over caused proportionate increases in AVP in the circulation. In normal men, plasma vasopressin was significantly correlated with concurrent urinary osmolality. Five patients with oat-cell bronchial carcinoma and hyponatraemia showed a marked increase of plasma vasopressin. Five patients with diabetes insipidus had significantly reduced, but detectable, levels of plasma AVP. The plasma concentration in these patients did not increase after water restriction.

Topics: Adult; Animals; Arginine Vasopressin; Biological Assay; Blood Volume; Bronchial Neoplasms; Carcinoma, Small Cell; Dehydration; Diabetes Insipidus; Dogs; Half-Life; Hemorrhage; Humans; Male; Osmolar Concentration; Posture; Radioimmunoassay; Urine; Vasopressins; Water; Water Deprivation

A radioimmunoassay method for the measurement of arginine-vasopressin (AVP) in human plasma has been developed which requires 5 ml of plasma and has a lower limit of detection of 1-8 pg/ml plasma. Arginine-vasopressin was found to be stable in whole blood for up to 1 h at room temperature and for at least 4 h at 4 degrees C, while in plasma stored at -20 degrees C no loss was seen over 10 days. Dehydration and rehydration in normal subjects produced appropriate changes in AVP concentration but there was considerable variability in the levels attained by individual subjects and no obvious correlation with plasma osmolality. No consistent increase in plasma AVP concentration was seen on change of posture from the recumbent to the upright position. Vigorous exercise produced a marked rise in plasma AVP concentrations in most subjects which could not be attributed simply to an increase in plasma osmolality. In fusion studies with Pitressin in normal subjects showed a mean half-life of 6-4 min with an overall plasma clearance rate of 8-5 ml/min/kg body weight and a mean volume of distribution of 5-33 l. In patients with a biochemical picture suggestive of inappropriate antidiuretic hormone secretion, markedly raised plasma AVP concentrations were found only in patients with bronchial carcinoma.

Topics: Arginine Vasopressin; Blood Preservation; Bronchial Neoplasms; Dehydration; Furosemide; Growth Hormone; Humans; Hydrocortisone; Hyponatremia; Leukemia; Osmolar Concentration; Physical Exertion; Posture; Radioimmunoassay; Thyrotropin; Urine; Vasopressins

A radioimmunoassay specific for arginine-vasopressin (AVP) developed in recent years has been applied to measurement of urinary AVP during physiological and clinical studies. Daily excretion of AVP was 34 +/- 10 ng (mean +/- SD) in 17 female normals and 69 +/- 45 ng in 17 male normals, this being a significant difference (p less than 0.01). After osmolar load (Carter-Robbins test) hourly excretion of AVP increased significantly in 7 males from 1.3 to 3.1 ng/h and in 6 females from 1.7 to 6.5 ng/h. Again the difference between male and female normals was significant. In both sexes a significant correlation between AVP excretion and either plasma osmolality or free-water clearance was found. When the osmolar load test was performed under constant angiotensin II perfusion in male subjects, their AVP excretion was significantly more elevated; this confirmed in man the hypothesis that angiotensin II is a stimulus to AVP secretion. Preliminary results of AVP excretion and response to osmolar load in diabetes insipidus are reported. Exceedingly high rate of excretion of AVP up to 55 330 ng/24 h have been found in cases of bronchial carcinoma with dilutional hyponatremia.

Topics: Aldosterone; Angiotensin II; Bronchial Neoplasms; Diabetes Insipidus; Female; Humans; Male; Osmolar Concentration; Thirst; Vasopressins; Water-Electrolyte Balance

Topics: Adrenocorticotropic Hormone; Bone Neoplasms; Bronchial Neoplasms; Carcinoma, Small Cell; Corticotropin-Releasing Hormone; Female; Genes, Regulator; Genetic Code; Hormones, Ectopic; Humans; Hypercalcemia; Hyperthyroidism; Male; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Parathyroid Hormone; Thyrotropin; Vasopressins

Topics: Adrenal Gland Neoplasms; Autopsy; Bone Neoplasms; Bronchial Neoplasms; Calcitonin; Carcinoma; Carcinoma, Small Cell; Humans; Hyponatremia; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Metastasis; Osmolar Concentration; Paraneoplastic Endocrine Syndromes; Syndrome; Vasopressins

Topics: Acute Disease; Bronchial Neoplasms; Humans; Lung Diseases; Sensory Receptor Cells; Smoking; Stress, Psychological; Vasopressins

Topics: Adult; Bronchial Neoplasms; Carcinoma; Diagnosis, Differential; Humans; Hyponatremia; Lung Neoplasms; Male; Muscular Diseases; Muscular Dystrophies; Osmolar Concentration; Syndrome; Vasopressins

Topics: Adenocarcinoma; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Bronchial Neoplasms; Carcinoma; Female; Gastrointestinal Neoplasms; Gonadotropins; Growth Hormone; Hormones, Ectopic; Humans; Hyperparathyroidism; Hyperthyroidism; Lung Neoplasms; Male; Paraneoplastic Endocrine Syndromes; Parathyroid Hormone; Pituitary Hormones; Sex Factors; Thymus Neoplasms; Thyroid Neoplasms; Thyrotropin; Urogenital Neoplasms; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma, Small Cell; Diabetes Insipidus; Humans; Hyponatremia; Iodine Isotopes; Radioimmunoassay; Vasopressins; Water; Water Deprivation

Topics: Autopsy; Brain Neoplasms; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Humans; Hypopituitarism; Hypothalamus; Male; Microscopy, Electron; Middle Aged; Neoplasm Metastasis; Paraneoplastic Endocrine Syndromes; Pituitary Gland; Pituitary Neoplasms; Vasopressins

Topics: Adrenocorticotropic Hormone; Bronchial Neoplasms; Dexamethasone; Diabetes Insipidus; Hormones, Ectopic; Humans; Hydrocortisone; Male; Osmolar Concentration; Vasopressins

Topics: Adult; Autopsy; Bicarbonates; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Chlorides; Cyclophosphamide; Hormones, Ectopic; Humans; Hyponatremia; Injections, Intravenous; Male; Osmolar Concentration; Sodium; Urea; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Diet; Hormones, Ectopic; Humans; Hyponatremia; Male; Natriuresis; Paraneoplastic Endocrine Syndromes; Sodium; Vasopressins; Water-Electrolyte Balance

Topics: Animals; Bronchial Neoplasms; Hormones, Ectopic; Humans; Lung Diseases; Pneumonia, Staphylococcal; Pneumonia, Viral; Vasopressins

Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenocortical Hyperfunction; Bronchial Neoplasms; Carcinoma, Bronchogenic; Female; Hormones, Ectopic; Humans; Hypercalcemia; Hyponatremia; Neoplasm Metastasis; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Female; Hormones, Ectopic; Humans; Hyponatremia; Middle Aged; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Hormones, Ectopic; Humans; Hyponatremia; Hypoventilation; Lung Neoplasms; Male; Middle Aged; Muscular Diseases; Myositis; Vasopressins

Topics: Aged; Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Hormones, Ectopic; Humans; Hyponatremia; Male; Mental Disorders; Vasopressins; Water-Electrolyte Balance

Topics: Animals; Biological Assay; Bronchial Neoplasms; Carcinoma, Bronchogenic; Chlorpropamide; Diabetes Insipidus; Female; Hemorrhage; Humans; Immune Sera; Labor, Obstetric; Nicotine; Pregnancy; Radioimmunoassay; Sheep; Vasopressins

Topics: Aged; Brain Damage, Chronic; Bronchial Neoplasms; Humans; Hypothyroidism; Male; Vasopressins; Water-Electrolyte Balance

Topics: Bronchial Neoplasms; Carcinoma, Squamous Cell; Central Nervous System Diseases; Hormones, Ectopic; Humans; Hyponatremia; Male; Middle Aged; Vasopressins

In an unselected series of 185 patients with histologically confirmed bronchial carcinoma 16 had endocrine disturbances attributable to the tumour (excluding pulmonary osteoarthropathy). Of these, 11 patients had hypercalcaemia; three inappropriate secretion of antidiuretic hormone; one Cushing's disease; three hypertrophic osteoarthropathy; and one gynaecomastia. Cushing's disease and inappropriate antidiuresis are specifically associated with oat-cell tumours, and hypercalcaemia occurs most frequently with squamous carcinoma. A negative correlation exists between gynaecomastia and osteoarthropathy on the one hand and oat-cell carcinoma on the other.

Topics: Adenocarcinoma; Bronchial Neoplasms; Carcinoid Tumor; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Chlorides; Cushing Syndrome; Endocrine System Diseases; Gynecomastia; Humans; Hydrocortisone; Hypercalcemia; Osteoarthropathy, Primary Hypertrophic; Sodium; Urea; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma; Electroencephalography; Humans; Hyponatremia; Middle Aged; Natriuresis; Neoplasm Metastasis; Vasopressins; Water Intoxication

Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Biological Assay; Brain Neoplasms; Bronchial Neoplasms; Central Nervous System Diseases; Child; Edema; Endocrine System Diseases; Glioblastoma; Humans; Male; Osmolar Concentration; Pituitary Diseases; Renin; Sodium Chloride; Vasopressins

Topics: Biopsy; Bronchi; Bronchial Neoplasms; Carcinoma, Bronchogenic; Cell Nucleolus; Cilia; Epithelium; Humans; Microscopy, Electron; Vasopressins

Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Alkalosis; Bronchial Neoplasms; Carcinoma; Endocrine System Diseases; Fludrocortisone; Humans; Hypercalcemia; Hypokalemia; Hyponatremia; Male; Plasma Volume; Vasopressins

Topics: Adult; Aged; Animals; Biological Assay; Blood Chemical Analysis; Blood Urea Nitrogen; Bronchial Neoplasms; Creatinine; Dexamethasone; Diuresis; Female; Fludrocortisone; Humans; Hyperaldosteronism; Hyponatremia; Male; Middle Aged; Natriuresis; Phenytoin; Rats; Tissue Extracts; Urine; Vasopressins; Water-Electrolyte Balance

Topics: Animals; Bronchial Neoplasms; Hormones, Ectopic; Humans; Hyponatremia; Lung Neoplasms; Male; Middle Aged; Natriuresis; Potassium; Rats; Vasopressins

Topics: Aged; Animals; Anura; Bronchial Neoplasms; Carcinoma; Humans; Hyponatremia; Hypopituitarism; Male; Neoplasm Metastasis; Pancreatic Neoplasms; Permeability; Sodium; Urinary Bladder; Vasopressins; Water

Topics: Bone Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous Cell; Diuresis; Humans; Hypercalcemia; Male; Middle Aged; Neoplasm Metastasis; Vasopressins

Topics: Bronchial Neoplasms; Chromatography, Ion Exchange; Humans; Hyponatremia; Vasopressins

Topics: Angiotensin II; Bronchial Neoplasms; Diuresis; Hormones, Ectopic; Humans; Lung Neoplasms; Male; Middle Aged; Renin; Vasopressins

Topics: Aldosterone; Blood Volume; Bronchial Neoplasms; Carcinoma; Cyclophosphamide; Diuresis; Electroencephalography; Hormones, Ectopic; Humans; Hyponatremia; Male; Middle Aged; Natriuresis; Plasma Volume; Radioisotope Teletherapy; Renin; Vasopressins

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Humans; Vasopressins

Topics: Brain Diseases; Bronchial Neoplasms; Humans; Hyponatremia; Vasopressins; Water Intoxication

Topics: Bronchial Neoplasms; Humans; Hyponatremia; Male; Middle Aged; Myasthenia Gravis; Vasopressins

Topics: Adult; Aldosterone; Bronchial Neoplasms; Carcinoma; Humans; Hyponatremia; Male; Vasopressins

Topics: Arginine Vasopressin; Bronchial Neoplasms; Carcinoma, Bronchogenic; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lymphatic Metastasis; Natriuresis; Neoplasms; Physiology; Urine; Vasopressins

Topics: Arginine Vasopressin; Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Drug Therapy; Fluids and Secretions; Humans; Hyponatremia; Mechlorethamine; Neoplasms; Urine; Vasopressins

Topics: Addison Disease; Arginine Vasopressin; Avena; Bronchial Neoplasms; Carcinoma, Small Cell; Cushing Syndrome; Gynecomastia; Humans; Hypercalcemia; Hyperthyroidism; Hyponatremia; Hypotension; Liver Cirrhosis; Male; Metabolism; Pathology; Physiology; Small Cell Lung Carcinoma; Sodium; Vasopressins

Topics: Blood Chemical Analysis; Bronchial Neoplasms; Carcinoma; Humans; Hyponatremia; Metabolism; Neoplasms; Urine; Vasopressins